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22 Possible Causes for TCRG, gene, rearrangements

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  • B-Precursor Acute Lymphoblastic Leukemia

    Gene delivery to human B-precursor acute lymphoblastic leukemia (ALL) cells was investigated using the enhanced green fluorescent protein (EGFP) as a reporter gene, measured[] The VγII rearrangement was the most common (46.8%) type in TCRG.[] However, an oligoclonal Ig heavy chain (IgH) rearrangement pattern has been observed in 30% of ALL patients and was shown to be the result of ongoing rearrangement events.[]

  • Peripheral T-cell Lymphoma

    This study therefore shows that DUSP22 behaves as a tumor suppressor gene in PTCL.[] PTCL was positive for CD3, CD4, CD5, CD10, and CD56, and showed identical TCRB and TCRG gene rearrangements to those detected initially.[] Identification of novel fusion genes has contributed significantly to improving the classification, biologic understanding, and therapeutic targeting of PTCLs.[]

  • Angioimmunoblastic Lymphadenopathy

    Profiling of gene expression patterns for a variety of genes in additional cases may be helpful in determining which factors predict the biological and clinical behaviour[] In the 5 patients in whom a TCRG gene rearrangement was evidenced in skin and lymph node samples, identical clones were detected in both.[] A clonal rearrangement of the TcR beta gene was detected in only one case at initial biopsy. No monoclonal rearrangement of Ig genes was observed.[]

  • Composite Lymphoma

    No evidence of retroviral infection was found using western blot and gene amplification techniques.[] Molecular test detected clonal rearrangement of both TCRG and IGH/K genes with identical amplicons for each gene in all 4 biopsies.[] Fluorescence in situ hybridization (FISH) identified an IGH-BCL2 rearrangement in both the FL and high-grade B-cell components while a MYC rearrangement was detected in the[]

  • Hepatosplenic T-cell Lymphoma

    , a known multidrug resistance gene.[] Furthermore, cytogenetic analysis revealed a novel chromosomal rearrangement, t(7;15)(p22;q21).[] This morphologic characteristic was associated with the presence of a productive clonal rearrangement of the T-cell receptor (TCR) delta gene.[]

  • Prolymphocytic Leukemia

    MeSH terms, Substances MeSH terms Aged Aged, 80 and over Female Follow-Up Studies Gene Expression Regulation, Leukemic* Gene Rearrangement* Genetic Association Studies Humans[] PCR based GeneScan analysis of T-cell receptor (TCR) genes demonstrated identical clonal TCRγ (TCRG) and TCRb (TCRB) gene rearrangements in peripheral blood and skin biopsy[] The cytogenetic rearrangements der(6)t(X;6) (p14;q25), der(13)t(13;14)(q22;q11),t(5;13)(q34;p11), r(17) (p13q21) and t(17;20)(q21;q13) have not been described previously in[]

  • Sézary Syndrome

    The goal of our study was to understand the genetic basis of the disease by looking for driver gene mutations and fusion genes in 15 erythrodermic patients with circulating[] TCRG gene rearrangement analysis TCRG gene rearrangement was studied by using a GC-clamp multiplex PCR denaturing gradient gel electrophoresis (DGGE) as originally described[] However, expression of five genes involved in rearrangements (TMEM244, EHD1, MTMR2, RNF123 and TOX) was altered in all patients.[]

  • Aggressive NK-Cell Leukemia

    It is well known that P-glycoprotein, which is a product of MDR1 gene and related to multi-drug resistance, is expressed on tumor cells of ENKL or ANKL.[] Polymerase chain reaction for TCRG clonality was polyclonal. Mutational analysis revealed missense mutations in the STAT3 gene in both cases studied.[] Due to the NK lineage, clonal rearrangements of lymphoid (T cell receptor; B cell receptor) genes are not seen.[]

  • Lymphomatoid Papulosis

    Polymerase chain reaction analysis with T-cell receptor γ-chain gene rearrangement (TCR-γR) was performed on the original lymph node and new skin lesions.[] We used polymerase chain reaction-based methods to assess the TCR-β chain (TCRB) and TCR-γ chain (TCRG) in both LyP and MF lesions of all patients.[] All cases harbored chromosomal rearrangements of the DUSP22-IRF4 locus on 6p25.3.[]

  • Bilineal Acute Leukemia

    The B-ALL cells presented a c.35G A p.G12D mutation in the KRAS gene, absent in the T-ALL.[] […] cytometry and PCR methods.Materials and Methods: Multiplex PCR reactions combined withheteroduplex analysis identied the monoclonal, blast-specicgene rearrangements (IGH, TCRd, TCRg[] Fluorescence in situ hybridization(FISH) analyses shown MLL rearrangement in 185 of 200 nuclei(92.5%), but no evidence of BCR/ABL1 rearrangement.[]