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44 Possible Causes for TP73, gene

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  • Thalidomide

    Although no allelic or genotypic differences were observed between the groups, we hypothesized that other regions in these genes and related genes may play an important role[ncbi.nlm.nih.gov] Investigations with Cereblon, a thalidomide target protein encoded by CRBN gene, have helped to understand thalidomide therapeutic and teratogenic properties.[ncbi.nlm.nih.gov] We also investigated ten polymorphisms in angiogenesis-related genes in 38 Brazilian TE individuals and 136 non-affected Brazilians.[ncbi.nlm.nih.gov]

  • Renal Cell Carcinoma

    (6;11) RCC harbouring a MALAT1-TFEB gene fusion.[ncbi.nlm.nih.gov] We found TP73-AS1 was upregulated in 40 ccRCC tissues compared with adjacent normal renal tissues and increased TP73-AS1 was correlated to aggressive clinicopathologic features[ncbi.nlm.nih.gov] Targeted next-generation sequencing revealed an ARID1B-TFE3 gene fusion.[ncbi.nlm.nih.gov]

  • Osteosarcoma

    Based on these selected genes, WGCNA further explored 142 genes included in the most OS metastasis-correlated module.[ncbi.nlm.nih.gov] […] by TP73-AS1 knockdown.[ncbi.nlm.nih.gov] Here, we speculated that genes of the module 5 were the essential genes that were associated to human osteosarcoma.[ncbi.nlm.nih.gov]

  • Anaplastic Astrocytoma

    In addition to identifying 16 gene classification signature, we also demonstrated that genes involved in epithelial-mesenchymal transition may play an important role in distinguishing[ncbi.nlm.nih.gov] Using PCR-SSCP and gene sequencing, we analyzed the TP53 and TP73 genes in a case of a grade III anaplastic astrocytoma that progressed to glioblastoma.[ncbi.nlm.nih.gov] […] far have resulted in gene lists that show little overlap.[ncbi.nlm.nih.gov]

  • Gastric Cancer

    The reprimo (RPRM) gene family is a group of single exon genes present exclusively within the vertebrate lineage.[ncbi.nlm.nih.gov] Importantly, TP73-AS1 could promote xenograft growth in vivo.[ncbi.nlm.nih.gov] Given that proliferation‑related genes may be potential target genes of HOXA5, we performed a series of experiments in vitro to examine the effects of HOXA5 on the proliferation[ncbi.nlm.nih.gov]

  • Clear Cell Renal Cell Carcinoma

    Missense mutations in the VHL gene during sporadic clear cell renal cell carcinoma were studied to evaluate their localization in relation to functionally important motifs[ncbi.nlm.nih.gov] We found TP73-AS1 was upregulated in 40 ccRCC tissues compared with adjacent normal renal tissues and increased TP73-AS1 was correlated to aggressive clinicopathologic features[ncbi.nlm.nih.gov] Clear-cell renal cell carcinoma (ccRCC) is the major renal cell carcinoma subtype, but its postsurgical prognosis varies among individual patients.We used gene expression,[ncbi.nlm.nih.gov]

  • Globoid Cell Leukodystrophy

    Globoid cell leukodystrophy (GLD; also known as Krabbe disease) is an invariably fatal lysosomal storage disorder caused by mutations in the galactocerebrosidase (GALC) gene[ncbi.nlm.nih.gov] The twitcher mouse is normally an pet model Rabbit polyclonal to TP73 for individual GLD (Krabbe disease).[crispr-reagents.com] The nucleotide sequence of the coding region and the gene organization were nearly identical to human.[ncbi.nlm.nih.gov]

  • Acute Lymphoblastic Leukemia

    DNA methylation is a dynamic process influencing gene expression by altering either coding or non-coding loci.[ncbi.nlm.nih.gov] In REH cells overexpressing MEF2D-SS18, genes related to B cell development were down-regulated, while genes related to drug sensitivity and B cell survival were up-regulated[ncbi.nlm.nih.gov] Leri-Weill syndrome (LWS) ranks among conditions with short stature homeobox gene (SHOX) haploinsufficiency.[ncbi.nlm.nih.gov]

  • Melphalan

    Compared to gene expression levels before and 20 days after therapy, at two days after melphalan treatment, we found gene regulation in the p53 and TNF pathways (MDM2, INPPD5[ncbi.nlm.nih.gov] Q-RT-PCR assays showed that TP73 was expressed in 57% of TP53wt HMCLs (4 out of 7) and 11% of TP53 abnormal (TP53abn) HMCLs (2 out of 18) (p 0.0463).[ncbi.nlm.nih.gov] […] by ranking genes based on their topological features.[ncbi.nlm.nih.gov]

  • Endometrial Adenocarcinoma

    Therefore, the necessity for a set of genes for CTC detection and not one single marker gene is demonstrated. qPCR is a fast, cost‑efficient and easy to perform technique,[ncbi.nlm.nih.gov] […] genes involved in the proliferation (MKI67), apoptosis (BAX, BCL2), signal transduction (EGFR), cell cycle (CCNE1, CCND1), cell adhesion (CDH1) and transcription regulation (TP73[ncbi.nlm.nih.gov] N-myc and metastasis-promoting gene MTA1, up-regulated the expression of apoptosis-promoting gene Fas and metastasis suppressor gene nm23-H1.[ncbi.nlm.nih.gov]

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