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10 Possible Causes for TRPM3

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  • Primidone

    Because TRPM3-deficient mice show inflammatory thermal hyperalgesia, pharmacological inhibition of TRPM3 may exert antinociceptive properties.[ncbi.nlm.nih.gov] Primidone blocked PregS-induced Cai influx through TRPM3 by allosteric modulation and reversibly inhibited atypical inwardly rectifying TRPM3 currents induced by coapplication[ncbi.nlm.nih.gov] […] blockers with half-maximal inhibition at 0.6 to 6 μM and marked specificity for TRPM3.[ncbi.nlm.nih.gov]

  • Methylprednisolone

    On the main sensory TRP channels (TRPA1, TRPV1, TRPM3, TRPM8) BTD exerts only minor activity.[ncbi.nlm.nih.gov]

  • Foveal Hypoplasia - Presenile Cataract Syndrome

    "Gene Regulation by PAX6: Structural-functional Correlations of Missense Mutants and Transcriptional Control of Trpm3/miR-204."[it.wikipedia.org]

  • Rosiglitazone

    Activity Rosiglitazone blocks K V 4.3 channels with an IC 50 24.5 μM 1 , K ir 6.1 channels with as IC 50 2 μM 2 and blocks TRPM3 channels with IC 50 5-10 μM 3 .[alomone.com] Data shows that Rosiglitazone blocks K V 4.3 channels with an IC 50 24.5 μM 2 , K ir 6.1 channels with as IC 50 2 μM 3 and blocks TRPM3 channels with IC 50 5-10 μM 4 .[alomone.com] Target K V 4, K ir 6.1, TRPM3, TRPC5 channels Lyophilized Powder Last update: 02/01/2019 Rosiglitazone (#R-125) is a highly pure, synthetic, and biologically active compound[alomone.com]

  • Primary Hypomagnesemia with Secondary Hypocalcemia

    Due to its prominent expression in the kidney, a role of TRPM3 in renal Ca 2 handling has been proposed.[doi.org] Molecular and functional characterization of the melastatin-related cation channel TRPM3. J Biol Chem 278 : 21493-21501, 2003 .[doi.org] Two different variants of TRPM3 have also been shown to represent Ca 2 -permeable ion channels ( 28 ), the shorter variant being activated by cell swelling ( 16 ).[doi.org]

  • Chronic Fatigue Syndrome

    TRPM3 immunophenotyping assay Due to the constitutive active property of TRPM3 protein and readily available anti-TRPM3 antibody, this study utilised anti-TRPM3 antibody to[dx.doi.org] The object of the study was to assess TRPM3 surface expression on NK and B lymphocytes from healthy controls, followed by a comparative investigation examining TRPM3 surface[dx.doi.org] Results TRPM3 cell surface expression was identified for NK and B lymphocytes in healthy controls (CD56 bright TRPM3 35.72 % 7.37; CD56 dim 5.74 % 2.00; B lymphocytes 2.05[dx.doi.org]

  • Hypericum Perforatum

    ., Schultz, G. ( 2005 ) Activation of TRPM3 by sphingosine. Naunyn-Schmiedebergs Arch.[doi.org] Google Scholar 21 Grimm, C., Kraft, R., Sauerbruch, S., Schultz, G., Harteneck, C. ( 2003 ) Molecular and functional characterization of the melastatin-related cation channel TRPM3[doi.org]

  • Crotamiton

    Vriens J, Owsianik G, Hofmann T, Philipp SE, Stab J, Chen X, Benoit M, Xue F, Janssens A, Kerselaers S, Oberwinkler J, Vennekens R, Gudermann T, Nilius B, Voets T (2011) TRPM3[doi.org]

  • Aniridia

    Siegfried, Alan Shiels and Francesc Palau , Mutation of the Melastatin-Related Cation Channel, TRPM3, Underlies Inherited Cataract and Glaucoma , PLoS ONE , 9 , 8 , (e104000[doi.org]

  • Mucolipidosis Type 4

    Alternative splicing switches the divalent cation selectivity of TRPM3 channels. J Biol Chem 280 : 22540–22548, 2005 .[doi.org] Molecular and functional characterization of the melastatin-related cation channel TRPM3. J Biol Chem 278 : 21493–21501, 2003 .[doi.org] ., TRPV6, TRPM3) have at some point been described as store-operated channels (SOCs), i.e., channels that are activated whenever intracellular Ca 2 stores become depleted.[doi.org]

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