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10 Possible Causes for Thomsen Friedenreich, antigen,, cryptic

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  • Streptococcus Pneumoniae

    The most widely accepted mechanism for pneumococcal HUS is endothelial cell damage by pre-formed antibodies against the Thomsen-Friedenreich antigen.[ncbi.nlm.nih.gov] Additionally strain R6 does not carry the cryptic plasmid pDP1 (see PubMed 17041037). Publications "Genome of the bacterium Streptococcus pneumoniae strain R6."[uniprot.org] A quick detection of urinary antigen helps in obtaining a documented result in case of Streptococcus pneumoniae CAP.[ncbi.nlm.nih.gov]

  • Streptococcus Pyogenes

    The Thomsen- Friedenreich antigen (T antigen) plays a role in the pathophysiology of pneumococcal HUS.[ncbi.nlm.nih.gov] However, such signatures might gradually become cryptic by amelioration occurring during island stabilization [ 16 ].[bmcgenomics.biomedcentral.com] The antigenicity of a selected group of antigens was further validated using a high-density peptide array technology that also identified the linear epitopes.[ncbi.nlm.nih.gov]

  • Thrombotic Thrombocytopenic Purpura

    Exposure of the ThomsenFriedenreich antigen on red blood cells strongly supports the diagnosis [ 3 ].[doi.org] The shear conditions of the blood flow unfold both anchored and freshly released ultra-large vWF multimers 70 , 71 , thereby exposing otherwise cryptic platelet-binding sites[doi.org] Those with an antigen level in the lowest quartile (antigen 11%) ( P .005).[ncbi.nlm.nih.gov]

  • Uremic Anemia

    However, there is evidence of a role for the ThomsenFriedenreich (TF) cryptantigen [ 39 ].[link.springer.com] Creuzburg K, Kohler B, Hempel H, Schreier P, Jacobs E, et al. (2005) Genetic structure and chromosomal integration site of the cryptic prophage CP-1639 encoding Shiga toxin[journals.plos.org] The pneumococcal organism produces a neuramidase enzyme, which can expose an antigen (T-antigen) present on erythrocytes, platelets, and glomeruli.[latunisiemedicale.com]

  • Atypical Hemolytic Uremic Syndrome

    Plasma therapy is contraindicated in Streptococcus pneumoniae –induced non–Stx-HUS; it may exacerbate the disease because adult plasma contains antibodies against the Thomsen-Friedenreich[emedicine.medscape.com] […] platelet, haptoglobin, LDH, schistocytes), all in the normal range.The condition of proteinuria as the only sign of thrombotic microangiopathy activity is here designated as "cryptic[ncbi.nlm.nih.gov] FACTOR B COMPLEMENT ANTIGEN 15.2-42.3 mg/dL SC5b-9 COMPLEMENT or 250 ng/mL FACTOR H COMPLEMENT ANTIGEN 23.6-43.1 mg/dL C4d COMPLEMENT ACTIVATION FRAGMENT or 9.8 mcg/mL CBb[mayomedicallaboratories.com]

  • Renal Cell Carcinoma

    Cao Y, Karsten U, Zerban H, Bannasch P (2000) Expression of MUC1, ThomsenFriedenreich-related antigens, and cytokeratin 19 in human renal cell carcinomas and tubular clear[doi.org] Proteolytic remodeling of the ECM by MMPs was shown to expose cryptic sites in collagen IV, normally hidden within the triple helical structure, leading to loss of integrin[doi.org] , encouraging the immune system to attack cancer cells bearing these antigens.[cancerresearch.org]

  • Thrombotic Microangiopathy

    Rarely pneumococcus or other infectious agents with neuraminidase can expose the Thomsen-Friedenreich antigen on cell surfaces to result in hemolysis and direct endothelial[thrombosisjournal.biomedcentral.com] A western blot assay detects autoantibodies to cryptic endothelial antigens in thrombotic microangiopathies.[link.springer.com] RESULTS: Despite a clinical diagnosis of TTP, the patient had normal ADAMTS-13 levels and increased VWF antigen levels with ultra-large von Willebrand factor multimers.[ncbi.nlm.nih.gov]

  • Clostridium Perfringens

    BACKGROUND: Red blood cell (RBC) Thomsen-Friedenreich antigen exposure (T activation) in infants with necrotizing enterocolitis (NEC) has occasionally been associated with[ncbi.nlm.nih.gov] The authors present a fatal ED case of massive acute intravascular hemolysis due to C perfringens septicemia, the result of a cryptic liver abscess.[mdedge.com] A year of infection in the intensive care unit: prospective whole genome sequencing of bacterial clinical isolates reveals cryptic transmissions and novel microbiota.[doi.org]

  • Microangiopathy

    Rarely pneumococcus or other infectious agents with neuraminidase can expose the Thomsen-Friedenreich antigen on cell surfaces to result in hemolysis and direct endothelial[thrombosisjournal.biomedcentral.com] A western blot assay detects autoantibodies to cryptic endothelial antigens in thrombotic microangiopathies.[link.springer.com] Pneumococcal HUS • 5-15% • N acetyl neuraminidase induced cell wall damage • Exposure of T antigen in platelets, RBCs and glomeruli • Severe AKI/ Pyothorax/Meningitis • Vancomycin[slideshare.net]

  • Santos Syndrome

    Bacterial neuraminidase removes sialic acids and thus lyses cell-surface glycoproteins and exposes Thomsen-Friedenreich antigen to preformed circulating immunoglobulin (Ig[emedicine.medscape.com] […] mutations with complex splicing outcomes and multiple messenger RNAs. 7 In a single index patient a 10-bp deletion in the acceptor site of intron 29 led to the presence of a cryptic[nejm.org] During the current admission, the levels of CEA, cancer antigen 19-9 (CA19-9) and CA 125 were found elevated.[romj.org]