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171 Possible Causes for XRCC3, gene

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  • Diffuse Gastric Cancer

    A germline truncating mutation in the gene encoding α-E-catenin (CTNNA1) was also recently discovered in a family with HDGC, but no other genes specifically predisposing to[ncbi.nlm.nih.gov] METHODS: ERCC1 118 T/C, XRCC1 399 G/A, XPD 312 G/A, XPD 751 A/C, XRCC3 241 C/T, MS 919 A/G, GSTP1 105 A/G, GSTM1-null/positive and GSTT1-null/positive genotypes were obtained[ncbi.nlm.nih.gov] Our study tend to screen and characterize germline variants for CDH1 gene in EODGC patients and in general population in China.[ncbi.nlm.nih.gov]

  • Obsessive-Compulsive Disorder

    Molecular genetic and gene-expression studies focused on familial and twin cases have shown a wide variety of variant genes related to OCD.[ncbi.nlm.nih.gov] This study further supports the involvement of the SLC6A4 gene in OCD through both genetic and epigenetic mechanisms.[ncbi.nlm.nih.gov] In addition, in haplotype-based association analyses, there was a significant association between the OXTR gene and the onset age in patients with OCD.[ncbi.nlm.nih.gov]

  • Benzene Poisoning

    Seventeen single nucleotide polymorphisms (SNPs) were identified in NQO1, CYP2E1, and MPO genes, including 6 novel SNPs in CYP2E1 and MPO.[ncbi.nlm.nih.gov] We found that no individuals had the XRCC2 codon 188 variant alleles or Met/Met genotype of XRCC3 codon 241 in this study population.[ncbi.nlm.nih.gov] The TaqMan technique was used to detect polymorphisms of CYP1A1, CYP1A2, CYP1B1, ADH1B, EPHX1, EPHX2, NQO1, MPO, GSTP1 and UGT1A6 genes.[ncbi.nlm.nih.gov]

  • Osteosarcoma

    Based on these selected genes, WGCNA further explored 142 genes included in the most OS metastasis-correlated module.[ncbi.nlm.nih.gov] We identified 12 SNVs in CTLA-4, IL-8, MDM2, PRCKG, RECQL5, TNF-a, TP53, XRCC3, and VEGF that correlated with osteosarcoma susceptibility.[ncbi.nlm.nih.gov] CONCLUSIONS: Here, we speculated that genes of the module 5 were the essential genes that were associated to human osteosarcoma.[ncbi.nlm.nih.gov]

  • Troglitazone

    Among the upregulated genes, hypoxia-inducible factor 1 (HIF-1)-responsive RTP801 was induced in a dose-dependent manner.[ncbi.nlm.nih.gov] LIG1, BRCA1, TOP2A, POLE2, RAD54L, GTSE1, POLE, PCNA, RAD51, MDC1, UIP1, RAD51AP1, HMGB2, RPA1, TYMS, POLQ, NEIL3, CCNA2, CHAF1A, PTTG1, MAP2K6, RFC5, FANCG, RPA3, FANCB, XRCC3[wjgnet.com] Abstract Gene expression and activity of matrix-metalloproteinases (MMP)-2 and -9 in macrophages are reduced through peroxisome proliferator-activated receptor gamma (PPARgamma[ncbi.nlm.nih.gov]

  • Gastrointestinal Stromal Tumor

    In recent years, researchers have identified specific gene mutations linked to gastrointestinal stromal tumors (GIST), which primarily occur in the stomach or small intestine[sciencedaily.com] ., XRCC3, Rad51, etc.).[ncbi.nlm.nih.gov] KEYWORDS: CTNNB1 (β-catenin) gene; anastomosis; fibromatosis; gastrointestinal stromal tumor; large bowel; molecular; mutational analysis; post surgery; sarcoma; sigmoid colon[ncbi.nlm.nih.gov]

  • Xeroderma Pigmentosum Complementation Group B

    Previous GeneCards Identifiers for XPC Gene GC03M014115 GC03M014161 GC03M014165 The protein encoded by this gene is a key component of the XPC complex, which plays an important[genecards.org] (X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 3): XRCC3 antibodies XRCC3 Proteins BRIP1 (BRCA1 Interacting Protein C-terminal Helicase 1): BRIP1 antibodies[antibodies-online.com] Northern blot analysis showed that the gene is continuously expressed in all stages of fly development.[ncbi.nlm.nih.gov]

  • Myelodysplasia

    genes related to immature progenitor (IMP) cells.[ncbi.nlm.nih.gov] The XRCC3 protein also functions in the double-strand break repair pathway and directly interacts with and stabilizes RAD51.[haematologica.org] Genes Dev. 2016 May 1;30(9):989-1001. doi: 10.1101/gad.278424.116.[ncbi.nlm.nih.gov]

  • Temozolomide

    Biopsy results suggested alveolar rhabdomyosarcoma bearing a methylated O6-methylguanine-DNA methyltransferase (MGMT) gene promoter.[ncbi.nlm.nih.gov] 17 119 Reference GG/GA 12 38 2.32 0.95-5.62 MGMT (rs2308327) AA 17 120 Reference GG/GA 12 37 2.40 0.99-5.84 MGMT (rs12917) CC 24 126 Reference TT/TC 5 31 0.84 0.28-2.55 XRCC3[academic.oup.com] In the course of tumor development, gene silencing by DNA methylation is an early and important mechanism by which tumor-suppressor genes are inactivated. 14,15 In a phase[nejm.org]

  • Squamous Cell Carcinoma of the Head and Neck

    BACKGROUND: Genomic imprinting is associated with many human diseases, including various types of cancers, however, no studies on gene imprinting are related to squamous cell[ncbi.nlm.nih.gov] ., Selected genetic polymorphisms in MGMT, XRCC1, XPD, and XRCC3 and risk of head and neck cancer: a pooled analysis, Cancer Epidemiol Biomarkers Prev., 2005, 14, 1747–1753[degruyter.com] We hypothesize that mRNA expression levels of NER genes are associated with risk of the squamous cell carcinoma of head and neck (SCCHN).[ncbi.nlm.nih.gov]

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