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102 Possible Causes for Abdominal Distension, Irinotecan, Peripheral Neuropathy

  • Pancreatic Adenocarcinoma

    Abdominal distension: Swelling of the abdomen, usually due to an increased amount of intestinal gas.[webmd.com] Options for front-line therapy include both infusional 5-fluorouracil, leucovorin, irinotecan, oxaliplatin (FOLFIRINOX) and the combination of gemcitabine plus nab-paclitaxel[ncbi.nlm.nih.gov] The main adverse effects are peripheral neuropathy, neutropenia, thrombocytopenia and fatigue.[nature.com]

  • Adenocarcinoma of the Ovary

    Case report An 11-year-old premenopausal girl presented with 3 months history of abdominal distension and respiratory distress.[ccij-online.org] The 50% growth inhibitory concentrations (IC50) (nM) of various anticancer drugs were: cisplatin 10,000, paclitaxel 80, SN-38 (irinotecan metabolite) 460, and gemcitabine[ncbi.nlm.nih.gov] Combination chemotherapy with irinotecan hydrochloride plus cisplatin has been reported to be effective for primary and recurrent or resistant CCC.[ncbi.nlm.nih.gov]

  • Malignant Neoplasm of Pancreas

    Caregivers or patients may notice abdominal distension and rapid weight gain. Some people also develop swelling of ankles and shortness of breath.[craigscause.ca] If you’re in fairly good health you may receive FOLFIRINOX (5-FU/ leucovorin / oxaliplatin / irinotecan ).[webmd.com] […] may occur in either the central nervous system (CNS) or the peripheral nervous system (PNS).[en.wikipedia.org]

  • Metastatic Ovarian Carcinoma

    At the end of 2010 she developed gradual abdominal distension, with the feeling of a mass in the hypogastric and left iliac region.[jmedicalcasereports.biomedcentral.com] Research output : Article 2000 Irinotecan--második vonalbeli kezeléssel szerzett tapasztalatok elórehaladott colorectalis daganatokban.[hungary.pure.elsevier.com] A specific chemotherapy regimen for rare clear-cell cancers is also under investigation: irinotecan combined with cisplatin. [62] PARP inhibitors have also shown promise in[en.wikipedia.org]

  • Porphyria

    Ileus and bladder distension may be present.[web.archive.org] […] dextropropoxyphene, ketorolac, metamizole, pentazocine Some cancer treatments like bexarotene, busulfan, chlorambucil, estramustine, etoposide, flutamide, idarubicin, ifosfamide, irinotecan[en.wikipedia.org] Any part of the nervous system may be involved with autonomic and peripheral neuropathy. Peripheral neuropathy may be symmetric or asymmetric.[symptoma.com]

  • Adenocarcinoma of the Colon

    We conclude that any child presenting with unexplained persistent constipation, abdominal distension or bleeding per rectum, colon cancer should be suspected and investigated[ncbi.nlm.nih.gov] Cetuximab Monotherapy and Cetuximab plus Irinotecan in Irinotecan-Refractory Metastatic Colorectal .N Engl J Med 2004;351:337-45. 13. T. Delaunoit1, S.R. Alberts, D.J.[scielo.mec.pt] Patients who received FOLFOXIRI had significantly more grade 3 and 4 toxicities, including neutropenia, stomatitis, and peripheral neuropathy.[cancer.gov]

  • Malignant Gastric Neoplasm

    About 1 year after surgery, she presented with persistent abdominal distension and underwent conservative managements.[ncbi.nlm.nih.gov] Irinotecan versus non‐irinotecan‐containing regimens for advanced gastric cancer Irinotecan versus non‐irinotecan‐containing regimens for advanced gastric cancer Patient or[doi.org] Side effects may include: tiredness nausea and vomiting nerve damage ( peripheral neuropathy ) hair loss diarrhoea anaemia (a lack of red blood cells) weight loss skin changes[nhs.uk]

  • Cecal Adenocarcinoma

    […] with occasional traces of blood, unquantified weight loss and nausea, and without vomiting or abdominal distension.[scielo.mec.pt] Irinotecan 24,25 Days 1 and 8: Irinotecan 125mg/m 2 IV over 30–90 minutes. Repeat cycle every 3 weeks. OR Day 1: Irinotecan 300–350mg/m 2 IV over 30–90 minutes.[cancertherapyadvisor.com] Patients who received FOLFOXIRI had significantly more grade 3 and 4 toxicities, including neutropenia, stomatitis, and peripheral neuropathy.[cancer.gov]

  • Gastric Adenocarcinoma

    On physical examination, the patient demonstrated abdominal distension with shifting dullness.[acgcasereports.gi.org] ., 5-FU (5 μ M); cisplatin (0.5 μ M); irinotecan (2.5 μ M); carboplatin (5 μ M); paclitaxel (2-4 n M); and X rays (1.8 Gy)] also potentiated gastric cancer clonogenic cell[ncbi.nlm.nih.gov] neuropathy grade 2 Inability to tolerate intravenous hydration e.g due to cardiac disease Co-morbidities (based on clinical judgement by the investigator) that in the view[clinicaltrials.gov]

  • Irritable Bowel Syndrome

    All symptoms of irritable bowel syndrome were exacerbated by bran, with bowel disturbance most often adversely affected, followed by abdominal distension and pain.[ncbi.nlm.nih.gov] Prevention of irinotecan induced diarrhea by probiotics: A randomized double blind, placebo controlled pilot study.[doi.org] neuropathy, ataxia, attention deficit hyperactivity disorder) or autoimmune diseases.[en.wikipedia.org]

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