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12 Possible Causes for Abdominal Pain, Alkaline Phosphatase Increased, Liver Biopsy showing Periportal Necrosis

  • Primary Sclerosing Cholangitis

    A 39-year-old man presented with diarrhea and abdominal pain.[ncbi.nlm.nih.gov] Liver function tests are usually abnormal (increased serum alkaline phosphatase (ALP) most commonly) and the bilirubin level can be raised with biliary obstruction.[royalfree.nhs.uk] He had suffered from repeated abdominal pain and cholangitis for 3 years.[ncbi.nlm.nih.gov]

  • Viral Hepatitis

    Besides features of viral hepatitis, the presence of typical abdominal pain, high serum amylase, and ultrasound or CT scan features suggested the diagnosis of acute pancreatitis[ncbi.nlm.nih.gov] Hepatosplenomegaly and laboratory evidence of mild to moderate hepatic dysfunction are the predominant features, with increased aminotransferases and alkaline phosphatase[doi.org] She was admitted to our hospital with fever, jaundice and abdominal pain. Hepatic and pancreatic enzymes were elevated.[ncbi.nlm.nih.gov]

  • Massive Hepatic Necrosis

    A, intraoperative (POD 0) wedge biopsy of the native liver showed massive hepatic necrosis and periportal ductular structure (HE, 200 ).[nature.com] Case Report A healthy, 30-year-old woman at 32 weeks gestation presented to the emergency department with sudden-onset headache and abdominal pain.[acgcasereports.gi.org] […] elevation of serum alkaline phosphatase and bilirubin.[annals.org]

  • Hepatitis B

    Hepatitis B Electron micrograph of hepatitis B virus Specialty Infectious disease, gastroenterology Symptoms None, yellowish skin, tiredness, dark urine, abdominal pain Classification[en.wikipedia.org] […] serum alkaline phosphatase (4%), increased liver enzymes (2%) Local: Pain at injection site (4%) Neuromuscular & skeletal: Myalgia (10%), joint stiffness (2%) Renal: Increased[drugs.com] After ten days of TDF administration, nausea, vomiting and abdominal pain developed.[ncbi.nlm.nih.gov]

  • Hepatitis A

    Infectious hepatitis A case of jaundice caused by hepatitis A Specialty Infectious disease, gastroenterology Symptoms Nausea, vomiting, diarrhea, dark urine, jaundice, fever, abdominal[en.wikipedia.org] Alkaline phosphatase activity also rises relatively late in the course of the infection, and tends to parallel serum bilirubin increases.[clinchem.org] She was admitted to our hospital with fever, jaundice and abdominal pain. Hepatic and pancreatic enzymes were elevated.[ncbi.nlm.nih.gov]

  • Autoimmune Hepatitis

    In more severe cases, biopsy typically shows periportal necrosis with mononuclear cell infiltrates (piecemeal necrosis) accompanied by variable periportal fibrosis and bile[merckmanuals.com] Common initial symptoms include fatigue or muscle aches or signs of acute liver inflammation including fever, jaundice, and right upper quadrant abdominal pain.[en.wikipedia.org] phosphatase – In 80-90% of patients; a sharp increase in the alkaline phosphatase values during the course of autoimmune disease may reflect the development of primary sclerosing[emedicine.com]

  • Primary Biliary Cirrhosis

    Liver biopsy showed lymphocytic and plasmacytic infiltration in the portal and periportal areas, with numerous areas of bridging centrilobular necrosis, indicating AIH.[ncbi.nlm.nih.gov] At 45 years of age, the patient complained of bloody diarrhea and abdominal pain, and she was diagnosed with ulcerative colitis by colonoscopy and histological examination[ncbi.nlm.nih.gov] We had also observed in the other three groups of patients that the average of the values of γ-glutamyl transpeptidase and alkaline phosphatase increases with the increase[ncbi.nlm.nih.gov]

  • Drug-induced Cholestatic Hepatitis

    Liver biopsy showed prominent spotty necrosis and focal confluent necrosis. Portal and mild periportal lymphomononuclear inflammation.[jcdr.net] She denied fever, rash or abdominal pain.[nature.com] […] of 1.5 N of alkaline phosphatase associated with an increase of ALT or AST and/or total bilirubin in patients with or without symptoms [ 15 , 16 ].[omicsonline.org]

  • Isoniazid Hepatitis

    Seven patients initially experienced excess fatigue, nausea, or abdominal pain, but waited until the onset of jaundice before seeking medical attention.[cdc.gov] Liver Function Test Serum bilirubin, SGOT, SGPT, Serum Alkaline phosphatase, Prothrombin time, HbsAg, IgM anti HBc for hepatitis B, blood urea and serum creatinine were investigated[omicsonline.org] The pattern of liver enzyme elevations is typically hepatocellular with marked increases in ALT levels ( 10 times ULN) and minimal increases in alkaline phosphatase values[livertox.nih.gov]

  • Chronic Active Hepatitis

    In more severe cases, biopsy typically shows periportal necrosis with mononuclear cell infiltrates (piecemeal necrosis) accompanied by variable periportal fibrosis and bile[merckmanuals.com] Chills Clay-colored stools Darkened urine Fever Jaundice (yellowing of the skin and eyes) Nausea Pain below the shoulder blade Right upper quadrant or middle abdominal pain[verywellhealth.com] The serum concentrations of transaminase enzymes, bilirubin, and alkaline phosphatase were increased, and a mild coagulopathy was present.[ncbi.nlm.nih.gov]

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