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18 Possible Causes for Abdominal Pain, Hepatomegaly, Liver Biopsy showing Periportal Necrosis

  • Primary Sclerosing Cholangitis

    Liver disease other than PSC was defined as autoimmune hepatitis, hepatitis, hepatomegaly, liver failure, cirrhosis, portal hypertension, cholangiocarcinoma, or hepatobiliary[ncbi.nlm.nih.gov] A 39-year-old man presented with diarrhea and abdominal pain.[ncbi.nlm.nih.gov] Hepatomegaly (may also have splenomegaly at presentation). Later stages: signs of cirrhosis, portal hypertension or hepatic failure.[patient.info]

  • Viral Hepatitis

    Three patients presented only jaundice and hepatomegaly; one also had liver failure.[ncbi.nlm.nih.gov] Besides features of viral hepatitis, the presence of typical abdominal pain, high serum amylase, and ultrasound or CT scan features suggested the diagnosis of acute pancreatitis[ncbi.nlm.nih.gov] In the icteric phase, the patients develop jaundice, gastrointestinal disturbance, dark urine, gray-colored stools, right upper quadrant pain, and hepatomegaly.[symptoma.com]

  • Hepatitis A

    The child was deeply icteric and had hepatomegaly. IgM antibodies for hepatitis A virus were positive.[ncbi.nlm.nih.gov] Infectious hepatitis A case of jaundice caused by hepatitis A Specialty Infectious disease, gastroenterology Symptoms Nausea, vomiting, diarrhea, dark urine, jaundice, fever, abdominal[en.wikipedia.org] The hepatomegaly continues for another 2-12 weeks and thereafter the liver regains its normal function. Hepatitis A is best diagnosed serologically.[symptoma.com]

  • Hepatitis B

    Hepatitis B Electron micrograph of hepatitis B virus Specialty Infectious disease, gastroenterology Symptoms None, yellowish skin, tiredness, dark urine, abdominal pain Classification[en.wikipedia.org] After ten days of TDF administration, nausea, vomiting and abdominal pain developed.[ncbi.nlm.nih.gov] As symptoms of abdominal pain and jaundice were presented on the fifth day, he re-admitted. The patient expired because of hepatorenal and cardiac insufficiency.[ncbi.nlm.nih.gov]

  • Massive Hepatic Necrosis

    Hepatic involvement is a common finding in cytomegalovirus mononucleosis as manifested by mild hepatomegaly, consistent increases in serum transaminase activity, and variable[annals.org] A, intraoperative (POD 0) wedge biopsy of the native liver showed massive hepatic necrosis and periportal ductular structure (HE, 200 ).[nature.com] Case Report A healthy, 30-year-old woman at 32 weeks gestation presented to the emergency department with sudden-onset headache and abdominal pain.[acgcasereports.gi.org]

  • Aflatoxicosis

    Symptoms include hepatomegaly, abdominal discomfo rt, anorexia, malaise, jaundice and oedema of legs, face and trunk.[aspergillus.org.uk] Patients will appear ill with fever, jaundice, nausea, vomiting, abdominal pain, and hemorrhagic diathesis, hepatomegaly, and elevated liver function tests.[visualdx.com] The affected liver showed hepatomegaly, paleness, wide areas of hemorrhages and necrosis.[khartoumspace.uofk.edu]

  • Autoimmune Hepatitis

    CT Nonspecific, ranging from normal to hepatomegaly and cirrhosis.[radiopaedia.org] In more severe cases, biopsy typically shows periportal necrosis with mononuclear cell infiltrates (piecemeal necrosis) accompanied by variable periportal fibrosis and bile[merckmanuals.com] Common initial symptoms include fatigue or muscle aches or signs of acute liver inflammation including fever, jaundice, and right upper quadrant abdominal pain.[en.wikipedia.org]

  • Primary Biliary Cirrhosis

    The multifactorial analysis identified bilirubinemia and hepatomegaly as independent predictive variables.[nejm.org] Liver biopsy showed lymphocytic and plasmacytic infiltration in the portal and periportal areas, with numerous areas of bridging centrilobular necrosis, indicating AIH.[ncbi.nlm.nih.gov] At 45 years of age, the patient complained of bloody diarrhea and abdominal pain, and she was diagnosed with ulcerative colitis by colonoscopy and histological examination[ncbi.nlm.nih.gov]

  • Bacterial Hepatitis

    In more severe cases, biopsy typically shows periportal necrosis with mononuclear cell infiltrates (piecemeal necrosis) accompanied by variable periportal fibrosis and bile[merckmanuals.com] pain WHO fact sheet of hepatitis Viral Hepatitis at the Centers for Disease Control[en.wikipedia.org] Summary Points New onset fever, abdominal pain, confusion, or other signs or symptoms of infection in a cirrhotic patient should prompt an evaluation of the ascitic fluid[hepatitisc.uw.edu]

  • Generalized Lipodystrophy

    The diagnosis is made on the basis of loss of body fat, muscular hypertrophy, acanthosis nigricans, hirsutism, hepatomegaly with fatty liver, hyperlipidemia and hyperglycemia[ncbi.nlm.nih.gov] Hepatomegaly was noticed, and histological examination of a liver biopsy specimen suggested severe hepatic steatosis and periportal necrosis.[ncbi.nlm.nih.gov] […] lesions and abdominal pain.[ncbi.nlm.nih.gov]

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