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12 Possible Causes for Abdominal Pain, Hypoglycemia, Liver Biopsy showing Periportal Necrosis

  • Massive Hepatic Necrosis

    A, intraoperative (POD 0) wedge biopsy of the native liver showed massive hepatic necrosis and periportal ductular structure (HE, 200 ).[nature.com] Hypoglycemia occurs in many patients with ALF and is often due to depletion of hepatic glycogen stores and impaired gluconeogenesis.[en.wikipedia.org] Case Report A healthy, 30-year-old woman at 32 weeks gestation presented to the emergency department with sudden-onset headache and abdominal pain.[acgcasereports.gi.org]

  • Viral Hepatitis

    Besides features of viral hepatitis, the presence of typical abdominal pain, high serum amylase, and ultrasound or CT scan features suggested the diagnosis of acute pancreatitis[ncbi.nlm.nih.gov] She was admitted to our hospital with fever, jaundice and abdominal pain. Hepatic and pancreatic enzymes were elevated.[ncbi.nlm.nih.gov] This case report, along with the review presented, describes a patient diagnosed with acute viral hepatitis, who developed a framework of intense abdominal pain and laboratorial[ncbi.nlm.nih.gov]

  • Aflatoxicosis

    Hypoglycemia, hyperlipidemia, and depletion of lymphocytes accompanied these lesions.[ncbi.nlm.nih.gov] Patients will appear ill with fever, jaundice, nausea, vomiting, abdominal pain, and hemorrhagic diathesis, hepatomegaly, and elevated liver function tests.[visualdx.com] Aflatoxins can cause: Nausea, vomiting, and abdominal pain Convulsions Pulmonary edema, which is fluid buildup (edema) in the lungs ('pulmon-') Cerebral edema, which is fluid[study.com]

  • Isoniazid Hepatitis

    Seven patients initially experienced excess fatigue, nausea, or abdominal pain, but waited until the onset of jaundice before seeking medical attention.[cdc.gov] Only 6 patients (1.4%; 95% CI, 0.53.2) had symptoms of hepatitis, such as asthenia, nausea, or mild abdominal pain.[natap.org] Usually, the onset is abrupt, with chills, fever, rash, pruritus, arthralgia, headache, abdominal pain, anorexia, nausea and vomiting.[patient.info]

  • Primary Biliary Cirrhosis

    Liver biopsy showed lymphocytic and plasmacytic infiltration in the portal and periportal areas, with numerous areas of bridging centrilobular necrosis, indicating AIH.[ncbi.nlm.nih.gov] A 46-year-old man with type 1 diabetes (age of onset 26 years) was admitted into our hospital due to poor glycemic control (HbA 1c 11.3%) with severe daily hypoglycemia and[care.diabetesjournals.org] At 45 years of age, the patient complained of bloody diarrhea and abdominal pain, and she was diagnosed with ulcerative colitis by colonoscopy and histological examination[ncbi.nlm.nih.gov]

  • Iron Poisoning

    Liver biopsy in a patient with hepatotoxicity will show hepatocellular necrosis in the periportal hepatocytes (Zone 1).[meducator3.net] The profound damage to the liver results in: hypoglycemia, hyperammonemia, coagulation defects, and hepatic encephalopathy occurs in the context of fulminant liver failure[medicinespecifics.com] Scarring in either organ can cause crampy abdominal pain and vomiting. Severe scarring of the liver ( cirrhosis ) can develop later.[merckmanuals.com]

  • Chronic Hepatitis

    In more severe cases, biopsy typically shows periportal necrosis with mononuclear cell infiltrates (piecemeal necrosis) accompanied by variable periportal fibrosis and bile[merckmanuals.com] Despite advances in intensive care management, mortality continues to be high (40–80%) and is partly related to ALF's complications, such as cerebral edema, sepsis, hypoglycemia[doi.org] But over time, they can experience the following: tiredness weight loss nausea abdominal pain severe itching jaundice (yellow discoloration of the skin and eyes) Eventually[hepc.liverfoundation.org]

  • Chronic Active Hepatitis

    In more severe cases, biopsy typically shows periportal necrosis with mononuclear cell infiltrates (piecemeal necrosis) accompanied by variable periportal fibrosis and bile[merckmanuals.com] Other serious, and also rare, consequences of acute viral hepatitis are aplastic anemia (which can be fatal), pancreatitis, hypoglycemia, and polyarteritis, a serious inflammation[skylinefamilypractice.net] Chills Clay-colored stools Darkened urine Fever Jaundice (yellowing of the skin and eyes) Nausea Pain below the shoulder blade Right upper quadrant or middle abdominal pain[verywellhealth.com]

  • Generalized Lipodystrophy

    Hepatomegaly was noticed, and histological examination of a liver biopsy specimen suggested severe hepatic steatosis and periportal necrosis.[ncbi.nlm.nih.gov] ADVERSE REACTIONS: Most common adverse reactions ( 10%) in clinical trials were headache, hypoglycemia, decreased weight, and abdominal pain.[myaleptpro.com] […] lesions and abdominal pain.[ncbi.nlm.nih.gov]

  • Drug-induced Cholestatic Hepatitis

    Liver biopsy showed prominent spotty necrosis and focal confluent necrosis. Portal and mild periportal lymphomononuclear inflammation.[jcdr.net] ., 1629 Hypocholesterolemic agents, 1961: July, 935-959 1695 Hypogammaglobulinemia, relation to infection in chronic lymphocytic leukemia, 1961: May, 603 Hypoglycemia, dizziness[kundoc.com] She denied fever, rash or abdominal pain.[nature.com]

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