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11 Possible Causes for Abdominal Tenderness, Mutation in the CDK6 Gene

  • Malignant Gastric Neoplasm

    Figure 5: Integrated molecular description of gastric cancer. a , Mutations, copy-number changes and translocations for select genes are shown across samples organized by[nature.com] Abdominal examination revealed that the liver dullness was on the left side. There was a little tenderness in the epigastrium, but no mass was felt.[casesjournal.biomedcentral.com] Additionally, frequent amplifications of cell cycle mediators ( CCNE1, CCND1 and CDK6 ) suggest the potential for therapeutic inhibition of cyclin-dependent kinases ( Supplementary[nature.com]

  • Gastric Adenocarcinoma

    In Pt2, the SETBP1 gene (p.S944N) was mutated, as it is in myeloid malignancies ( 20 ), together with amplification of AKAP9 and CDK6 (cyclin-dependent kinase 6).[pnas.org] On examination, she had generalized abdominal tenderness.[healio.com] Figure 5: Integrated molecular description of gastric cancer. a, Mutations, copy-number changes and translocations for select genes are shown across samples organized by molecular[nature.com]

  • Gallbladder Carcinoma

    This tendency is the same as that for K-ras mutations and the pancreaticobiliary maljunction may override the effect of p53 gene mutations.[atlasgeneticsoncology.org] Gene Name CDKN2A (cyclin dependent kinase 2a / p16) Location 9p21.3 Dna / Rna 3 exons Protein Regulatory protein in the cell cycle and cyclin-dependent kinase ( cdk4 / cdk6[atlasgeneticsoncology.org] The tumor suppressor gene p16 is commonly inactivated in many neoplasms.[atlasgeneticsoncology.org]

  • Biliary Carcinoma

    This tendency is the same as that for K-ras mutations and the pancreaticobiliary maljunction may override the effect of p53 gene mutations.[atlasgeneticsoncology.org] Physical examination revealed scleral icterus with yellowing of the skin, but no abdominal tenderness and no abdominal masses, bilirubin 8.1 mg/dl, AST 121 IU/l, ALT 115 IU[karger.com] Abdominal pain is often a late symptom and is usually located in the right upper quadrant of the belly and may be associated with a tender, enlarged liver.[medicinenet.com]

  • Pancreatic Neoplasm

    Thus when mutations in the CDKN2A gene disrupt the function of p16(INK4), there is improper progression from the G1 to the S phase, allowing continued, uncontrolled cell proliferation[ncbi.nlm.nih.gov] […] pain and a palpable, non-tender, upper abdominal mass Also symptoms related to an intra-abdominal mass effect, such as discomfort, nausea, vomiting and early satiety Radiology[pathologyoutlines.com] Symptoms The signs and symptoms of precancerous conditions of the pancreas include: vague abdominal pain or discomfort a firm, but not tender, lump in the abdomen yellowing[cancer.ca]

  • Rhabdomyosarcoma

    The discovery that p16 gene is mutated or deleted in a striking proportion of human tumors raised the possibility that abnormalities in p16 might predispose to cancer development[ncbi.nlm.nih.gov] An emergency physical examination revealed upper abdominal tenderness and distention, with a mass of approximately 20 20 cm, and pitting edema of the lower limbs.[journals.lww.com] […] induces dephosphoryla-tion of pRB by inhibiting binding of cyclin-dependent kinase (CDK)4 and CDK6 to cyclin D, resulting in G1 growth arrest.[ncbi.nlm.nih.gov]

  • Adenocarcinoma of Gallbladder and Extrahepatic Biliary Tract

    This tendency is the same as that for K-ras mutations and the pancreaticobiliary maljunction may override the effect of p53 gene mutations.[atlasgeneticsoncology.org] Abdominal pain is often a late symptom and is usually located in the right upper quadrant of the belly and may be associated with a tender, enlarged liver.[medicinenet.com] CDKN2A serves a role in cell cycle regulation through the inhibition of cyclin dependent kinases (CDK), including CDK4 and CDK6, and acts as a tumor suppressor gene in melanoma[spandidos-publications.com]

  • Gastric Cancer

    Figure 5: Integrated molecular description of gastric cancer. a, Mutations, copy-number changes and translocations for select genes are shown across samples organized by molecular[nature.com] Then examine the abdomen: inspect for any obvious abdominal masses, palpate for tenderness and percuss for ascities.[fastbleep.com] Additionally, frequent amplifications of cell cycle mediators ( CCNE1, CCND1 and CDK6 ) suggest the potential for therapeutic inhibition of cyclin-dependent kinases ( Supplementary[nature.com]

  • Burkitt Lymphoma

    , PTEN, NOTCH1, and ATM ; amplifications of RAF1, MDM4, MDM2, KRAS, IKBKE, and CDK6 ; deletion of CDKN2A ; overexpression of MIR17HG ; activating mutations of TCF3 and/or[atlasgeneticsoncology.org] The abdomen was distended with diffuse tenderness, and bowel sounds were present.[ncbi.nlm.nih.gov] Rapidly enlarging, non-tender lymph nodes in the neck/jaw.[patient.info]

  • Neuroectodermal Tumor

    Poor prognosis: Group 3, MYC amplification, photoreceptor/GABAergic gene expression Intermediate prognosis: Group 4, gene expression of neuronal/glutamatergic, CDK6 amplification[en.wikipedia.org] In addition, there was an abdominal lump in the epigastrium, measuring12 8 cm, which was hard in consistency, not tender, not moving with respiration, and non-ballotable.[ccij-online.org] The cells have MYC amplification and gene expression of photorecepto/GABAergic. Group 4. This is the most common sub-group. CDK6 and MYCN are amplified.[cedars-sinai.org]

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