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2,146 Possible Causes for Abnormal Amniotic Fluid, Delayed Milestone, Wide Space Between the First and Second Toe

  • Down Syndrome

    One study found that mice with Down syndrome who were treated in the womb with specific chemicals had no delay in achieving several developmental milestones. 1 Another study[nichd.nih.gov] Therefore, alterations in amniotic fluid metabolites may provide important clues to understanding the etiology of fetal disease and help to develop diagnostic testing for[ncbi.nlm.nih.gov] A wide space, often with a deep fissure between the first and second toes, is also common.[dx.doi.org]

  • Propionic Acidemia

    At 3 years of age, neurodevelopment showed globally delayed milestones.[ncbi.nlm.nih.gov] This experience demonstrates the value of analysis of abnormal metabolites in amniotic fluid and highlights a problem that could confound the prenatal diagnosis of any condition[ncbi.nlm.nih.gov] Some children with propionic acidemia (PROP) have developmental delays.[babysfirsttest.org]

    Missing: Wide Space Between the First and Second Toe
  • Mental Retardation

    In mental retardation, the child tends to have delayed milestones and will be slow in talking and walking.[differencebetween.net] A small amount of the fluid surrounding the fetus (amniotic fluid) is drawn out through a needle inserted into the mother's womb.[medical-dictionary.thefreedictionary.com] milestones, especially language development Behavioral phenotype may also aid diagnosis as course evolves Cytogenetic studies; brain imaging; metabolic studies Will vary[aafp.org]

    Missing: Wide Space Between the First and Second Toe
  • Ring Chromosome 10

    On the last examination at 13 months of age, her development milestones were found to be delayed. She could not sit unsupported and her head control was insufficient.[molecularcytogenetics.biomedcentral.com] […] in fetuses but both at this time are just a week shy of chorion villi (CVS) or amniotic fluid (AFS) assessment.[tandfonline.com] 1st and 2nd toes Gap between first and second toe Increased space between first and second toes Sandal gap between first and second toes Wide space between 1st, 2nd toes[rarediseases.info.nih.gov]

  • Hyperargininemia

    Delayed milestones were present in eight cases (53.3%). Regression of acquired milestones was seen in three cases (33.3%).[pediatricneurosciences.com] Symptoms are progressive spastic paraplegia, failure to thrive, delayed milestones, hyperactivity and irritability, with episodic vomiting, hyperammonemia and seizures.[easternbiotech.com] They may have delays in reaching developmental milestones and may lose skills that they had already developed.[thinkgenetic.com]

    Missing: Wide Space Between the First and Second Toe
  • Multiple Carboxylase Deficiency

    This is a case of a 3-year-old boy presenting with delayed developmental milestones, tachypnea, progressively increasing ataxia, alopecia and dermatitis, all which dramatically[e-ijd.org] Some children with holocarboxylase synthase deficiency (MCD) have developmental delays.[babysfirsttest.org] If you think that your baby is not meeting their developmental milestones, ask your baby’s doctor about the next steps in accessing a developmental evaluation and care.[babysfirsttest.org]

    Missing: Wide Space Between the First and Second Toe
  • Niemann-Pick Disease Type C

    Neurological symptoms were generally more common in NP-C cases 4years of age than in younger patients, with the exception of hypotonia and delayed developmental milestones[ncbi.nlm.nih.gov] Tests on amniotic or ascites fluid cells allow to characterize the biochemical phenotype, leading to search for molecular abnormalities.[ncbi.nlm.nih.gov] […] development milestones childhood presentation: ataxia, falls, poor school performance adolescent and adult prestenation: psychiatric illnesses, ataxia Radiographic features[radiopaedia.org]

    Missing: Wide Space Between the First and Second Toe
  • CHARGE Syndrome

    Developmental delayDelayed motor milestones, language delay, mental retardation Educational, behavioural, social adjustment issues; Autistic-like problems; Obsessive compulsive[doi.org] Prenatal Amniotic fluid: Minimum total specimen size 15 mL Chorionic villi: Minimum total specimen size 4 mg Postnatal Whole blood: Minimum 5-10 mL in sodium heparin tube[sema4genomics.com] ; self-image Growth deficiency Growth deficiencies – Short stature Borderline growth hormone (GH) stimulation tests Growth hormone (GH) replacement Obesity Developmental delay[doi.org]

    Missing: Wide Space Between the First and Second Toe
  • Achondroplasia

    Motor development of the child is delayed. Milestones such as head control and independent sitting, standing, and ambulation may get delayed by as much as by 6 months.[boneandspine.com] […] of fetal genomic DNA obtained by aspiration of amniotic fluid.[ncbi.nlm.nih.gov] […] developmental milestones, and spinal stenosis (narrowing of the open spaces within the spine).[paleyinstitute.org]

    Missing: Wide Space Between the First and Second Toe
  • Xeroderma Pigmentosum

    XFE/XP51RO survived until age 16 and was described as meeting early developmental milestones [ 22 ].[ojrd.biomedcentral.com] […] cells may be used to diagnose the condition prior to birth Amniocentesis is a test conducted to diagnose fetal abnormalities by removing a small amount of amniotic fluid[dovemed.com] Patient XPCS1CD suffered global developmental delay with severe growth retardation. She survived until age 12.[ojrd.biomedcentral.com]

    Missing: Wide Space Between the First and Second Toe