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4,752 Possible Causes for Abnormal Amniotic Fluid, Lethargy, Wide Space Between the First and Second Toe

  • Down Syndrome

    Symptoms of an under active thyroid include, lethargy, weight gain and slow reactions, both physical and mental.[] Therefore, alterations in amniotic fluid metabolites may provide important clues to understanding the etiology of fetal disease and help to develop diagnostic testing for[] A wide space, often with a deep fissure between the first and second toes, is also common.[]

  • Propionic Acidemia

    The condition causes lethargy and striatal degeneration with motor impairment in humans. How propionate exerts its toxic effect is unclear.[] This experience demonstrates the value of analysis of abnormal metabolites in amniotic fluid and highlights a problem that could confound the prenatal diagnosis of any condition[] Propionic acidemia usually presents in the newborn period with severe metabolic acidosis and lethargy.[]

    Missing: Wide Space Between the First and Second Toe
  • Isovaleric Acidemia

    This report concerns an infant who presented at 10 days of age because of lethargy, poor feeding, hypothermia, cholestasis, and thrombocytopenia, leukopenia, and profound[] Isovaleric acidemia (IVA) is characterized by periodic vomiting, lethargy, coma, ketoacidosis and a 'sweaty feet' odor.[] […] deficiency in isovaleryl-CoA dehydrogenase, that has wide clinical variability and that can present in infancy with acute manifestations of vomiting, failure to thrive, seizures, lethargy[]

    Missing: Wide Space Between the First and Second Toe
  • Methylmalonic Acidemia

    A 14 month-old boy presented with an acute generalized dystonia and lethargy preceded by fever, vomiting and lethargy at the age of 13 months.[] She had clinical signs of diabetic ketoacidosis such as dehydration, deep sighing respiration, smell of ketones, lethargy, and vomiting.[] Methylmalonic acidemia (MMA) is an inborn error of organic acid metabolism that occurs in infancy with hypotonia, vomiting, dehydration, lethargy and failure to thrive and[]

    Missing: Wide Space Between the First and Second Toe
  • Carbamoyl Phosphate Synthetase Deficiency

    Presentation History In homozygous neonates, early-onset lethargy and, in some cases, seizures are often the first signs of abnormality.[] (OMIM:237300) of the urea cycle, which is chemically characterised by hyperammonaemia and clinically characterised by protein intolerance, intermittent ataxia, seizures, lethargy[] Clinical description In the neonatal-onset form of CPS1D, patients are usually healthy at birth but after few days they begin to manifest with lethargy and unwillingness to[]

    Missing: Wide Space Between the First and Second Toe
  • HMG-CoA Lyase Deficiency

    The clinical presentation of an acidotic attack is lethargy, hyperpnoea, tachypnoea and seizures, either at birth (two infants), following first feeding (in five infants),[] The disease is characterized by recurrent episodes of metabolic acidosis, hyperammonemia without ketosis, hypoglycemia, lethargy, hepatomegaly, and seizures.[] The lack of energy causes seizures and lethargy, accompanied by metabolic acidosis and hypoketotic hypoglycemia.[]

    Missing: Wide Space Between the First and Second Toe
  • Ornithine Transcarbamylase Deficiency

    Ornithine transcarbamylase deficiency causes vomiting, lethargy, hyperventilation, and even death, mainly in the neonatal period.[] The patient had suffered episodes of hyperammonemic encephalopathy ranging from lethargy to coma, treated by hemodialysis twice before LDLT, and her intelligence quotient[] Her parents related a history of recurrent episodes of vomiting, meat refusal, lethargy, and convulsions since childhood, and measurement of plasma ammonemia levels was the[]

    Missing: Wide Space Between the First and Second Toe
  • Maple Syrup Urine Disease

    Disease definition A rare inherited disorder of branched-chain amino acid metabolism classically characterized by poor feeding, lethargy, vomiting and a maple syrup odor in[] They may present with lethargy, vomiting, irritability, abnormal movements, poor feeding habits and poor weight gain which are eminently the offshoot of the neurological effects[] The early onset classic form manifests after birth by lethargy, poor feeding and neurological signs of intoxication.[]

    Missing: Wide Space Between the First and Second Toe
  • Multiple Carboxylase Deficiency

    Clinical considerations: Poor feeding, vomiting, lethargy, tachypnea Ketonuria Metabolic ketoacidosis Hyperammonemia Hypoglycemia Referral: If signs are present or infant[] Primary Care Management Upon Notification of the Screen Contact the family and evaluate the infant for poor feeding, vomiting, or lethargy.[] Affected infants often have immunodeficiency diseases, difficulty feeding, breathing problems, a skin rash, hair loss (alopecia), and a lack of energy (lethargy).[]

    Missing: Wide Space Between the First and Second Toe
  • Argininosuccinic Aciduria

    If untreated, worsening lethargy, seizures, coma and death may occur. Late-onset ASA is usually triggered by an acute infection, stress or after high protein intake.[] Symptoms of argininosuccinic aciduria include: Lethargy Loss of appetite Erratic breathing Poorly controlled body temperature Seizures Coma Hepatomegaly Hypotonia Apnea If[] Neonates with severe neonatal-onset ASA usually appear normal during the first 24-48 hours after birth but within a few days present with severe hyperammonemia manifesting with lethargy[]

    Missing: Wide Space Between the First and Second Toe

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