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325 Possible Causes for Abnormal Finger-to-Nose Test, Dysdiadochokinesis, Mutation in the WWOX Gene

  • Multiple Sclerosis

    A disorder of the central nervous system marked by weakness, numbness, a loss of muscle coordination, and problems with vision, speech, and bladder control. Multiple sclerosis is thought to be an autoimmune disease in which the body's immune system destroys myelin. Myelin is a substance that contains both protein[…][icd9data.com]

    Missing: Mutation in the WWOX Gene
  • Huntington's Disease

    Huntington disease (HD) is an autosomal dominant inherited neurodegenerative disease characterized by progressive motor, behavioral, and cognitive decline, culminating in death. It is caused by an expanded CAG repeat in the huntingtin gene. Even years before symptoms become overt, mutation carriers show subtle but[…][ncbi.nlm.nih.gov]

    Missing: Mutation in the WWOX Gene
  • Cerebellar Disease

    WWOX is mutated in autosomal recessive cerebellar ataxia with epilepsy and mental retardation.[genome.jp] Heel to shin test Have patient run their heel down the contralateral shin (this is equivalent the finger to nose test).[stanfordmedicine25.stanford.edu] Limb ataxia is shown by limbs that are clumsy, discoordinated, and that have difficulty with rapidly alternating movements (a phenomenon unhelpfully known as dysdiadochokinesis[medicguide.blogspot.com]

  • Spinocerebellar Ataxia Type 12

    Mutation in the WWOX gene, D. schematic of the WWOX gene). Figure adapted from WWOX.[epilepsygenetics.net] Neurological examination revealed normal higher mental functions (normal Mini-Mental State Examination), fingernose test showed gross dysmetria and tandem gait was impaired[academic.oup.com] MalaCards based summary : Spinocerebellar Ataxia 12, also known as sca12, is related to spinocerebellar ataxia 36 and aceruloplasminemia, and has symptoms including dysdiadochokinesis[malacards.org]

  • Alcoholic Cerebellar Degeneration

    Other impairments on the neurologic exam that may raise suspicion for a cerebellar disorder include: impaired heel-shin test, impaired finger-nose-finger test (dysmetria),[mdedge.com] Examine arms for limb ataxia (see above): rebound of outstretched arms, finger-nose test for past pointing, check for dysdiadochokinesis.[patient.info] Symptoms of cerebellar hemisphere injury include: Dysdiadochokinesis (difficulty with rapid alternating movements) Dysmetria of the hands and arm (lack of coordination or[clinicaladvisor.com]

    Missing: Mutation in the WWOX Gene
  • Cerebellar Mass Lesion

    […] to nose test abnormality Gait disturbance/abnormality Headache Headache improved with position change Headache worse with position change Headache worse with valsalva/Bowel[howmed.net] Dysdiadochokinesis is tested by asking the patient to hold up their hands and rapidly pronate and supinate repetitively.[patient.info] Clinical signs of these deficits are detected by the presence of dysmetria in finger-to-nose or heel-to-shin testing, and dysdiadochokinesis demonstrated by testing of rapid[clinicalgate.com]

    Missing: Mutation in the WWOX Gene
  • Cerebellar Neoplasm

    Clinical signs of these deficits are detected by the presence of dysmetria in finger-to-nose or heel-to-shin testing, and dysdiadochokinesis demonstrated by testing of rapid[clinicalgate.com] Dysdiadochokinesis is the irregular performance of rapid alternating movements. Intention tremors may be present on an attempt to touch an object.[dizziness-and-balance.com]

    Missing: Mutation in the WWOX Gene
  • Cerebellar Infarction

    Examine arms for limb ataxia (see above): rebound of outstretched arms, finger-nose test for past pointing, check for dysdiadochokinesis.[patient.info] Examine arms for limb ataxia (see above): rebound of outstretched arms, finger-nose test for past pointing, check for dysdiadochokinesis.[patient.info] Ask the patient to repeat "baby hippopotamus" - look for dysarthria and abnormal speech rhythm and syllable emphasis.[patient.info]

    Missing: Mutation in the WWOX Gene
  • Chorea Gravidarum

    During the examination see if you can elicit any features of ataxia (dysdiadochokinesis, intention tremor, past pointing, broad based gait), rigidity and bradykinesia.[ptpaces.wordpress.com]

    Missing: Mutation in the WWOX Gene
  • Juvenile Paralysis Agitans of Hunt

    […] undergrowth Motor delay Insulin resistance Hypergonadotropic hypogonadism Bilateral cryptorchidism Abnormal lung morphology Acanthosis nigricans Bone marrow hypocellularity Goiter Dysdiadochokinesis[mendelian.co]

    Missing: Mutation in the WWOX Gene