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80 Possible Causes for Abnormal Gait, Apathy, Deep White Matter Changes

  • Binswanger Disease

    Patients with this disease usually present with apathy, agitation, and bilateral corticospinal or bulbar signs Tags: binswanger' , s-disease , subcortical-dementia , white-matter-atrophy[medicalvideos.com] OBJECTIVES: To analyse the diagnostic and prognostic value of periventricular hyperintensity (PVH) and deep white matter hyperintensity (DWMH) magnetic resonance imaging ([ncbi.nlm.nih.gov] The abnormality of gait that may occur in patients with subcortical arteriosclerotic encephalopathy is described in 12 patients in whom difficulty walking was the presenting[medigoo.com]

  • Huntington's Disease

    Apathy severity increases in the motormanifest stages of Huntington's disease. HDGECs can adequately assess their level of apathy on a self-report questionnaire.[ncbi.nlm.nih.gov] Both deep grey matter and to a lesser degree white matter are involved in HD.[radiopaedia.org] Gait abnormalities: Gait abnormalities start developing in the intermediate stage of the disease. The gait is irregular and unsteady.[symptoma.com]

  • Normal Pressure Hydrocephalus

    Among 46 patients with suspicion of iNPH (77.6 6.7years; 34.8% women), 30 (65.2%) presented apathy (defined by a score 14 on the Starkstein apathy scale).[ncbi.nlm.nih.gov] White matter changes (WMC) INPH is known to be associated with deep white matter changes (DWMC) and smooth periventricular hyperintensity (PVH) [ 51 ] on MRI ( Figure 2B )[intechopen.com] Other symptoms of NPH are urinary incontinence, and abnormal gait.[symptoma.com]

  • Creutzfeldt Jakob Disease

    Whether symptoms develop gradually or abruptly, mental decline progresses, often producing such symptoms as neglect of personal hygiene, apathy, and irritability.[web.archive.org] Some other features, such as the presence of abnormal hyperintensity in the periaqueductal gray matter and posterior deep white matter tracts, were also common, and although[ajnr.org] People with CJD will have ataxia, or difficulty controlling body movements, abnormal gait, speech, and dementia. It is always fatal, and there is no cure.[medicalnewstoday.com]

  • CADASIL Syndrome

    Psychiatric disorders are also common and include depression, apathy and personality changes.[orpha.net] MR imaging lesion load correlated with some clinical features including stroke and dementia, whereas depression is more common in individuals with deep white matter changes[ajnr.org] This can result in an unsteady and wide based gait or sometimes an abnormal gait due to small steps. Should antiplatelet agents such as Aspirin be prescribed in CADASIL?[cambridgestroke.com]

  • Alcohol Dementia

    ARD patients often have symptoms of both forms, i.e. impaired ability to plan, apathy, and memory loss. ARD may occur with other forms of dementia (mixed dementia).[en.wikipedia.org] The CT showed prominent sulci and gyri with deep white matter changes. There were no other abnormalities.[gponline.com] This disorder is characterized by paralysis of eye movements, abnormal stance and gait, and markedly deranged mental function.[newenglandnightingales.com]

  • Pineal Gland Cyst

    Apathy, fatigue I had been incredibly tired all the time.[pinealglandcystsurgery.com] Today I received my results stating I have a few like foci of increased T2 signal in the deep periventricular white matter regions.[healthcaremagic.com] Attacks of fear, insecurity and loss of balance (in the elevator, while driving in a tunnel, on the highway, while walking) Strange headaches, tingling and pressure in my head Apathy[pinealglandcystsurgery.com]

  • Stroke

    However, there is no current consensus on the treatment of post-stroke apathy, which mainly depends on the underlying etiology and comorbidities.[ncbi.nlm.nih.gov] Early features include: loss of grey-white matter differentiation, and hypoattenuation of deep nuclei: lentiform nucleus changes seen as early as 1 hour after occlusion, visible[radiopaedia.org] Asymmetric step length is a common abnormal gait pattern in hemiplegic stroke patients.[ncbi.nlm.nih.gov]

  • Dementia

    Apathy, depression, irritability, agitation, and anxiety are the most frequently detected neuropsychiatric symptoms of AD.[ncbi.nlm.nih.gov] It may be particularly related to frontal deep white matter lesions. 16 Cognitive and behavioral changes in SVD are due to disruption of the frontal cortico-subcortical circuit[doi.org] walking experiencing behaviour changes that may escalate and include aggression.[web.archive.org]

  • Multi-Infarct Dementia

    […] include: Forgetfulness (but not as severe as Alzheimer's disease) Urinary incontinence Difficulty walking Clumsiness Changes in personality or mood (most likely in the form of apathy[alzheimers.emedtv.com] Several pathogenic mechanisms appear implicated in the causation the deep white matter changes of Binswanger's disease, and hypoxia-ischemia resulting from watershed injury[web.archive.org] Common neurological signs (e.g., abnormal reflexes, weakness of an extremity, gait disturbance) are discussed in the “Diagnostic Features” section.[courses.lumenlearning.com]

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