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92 Possible Causes for Abnormal Gait, Basal Ganglia Lesion, Deep White Matter Changes

  • Stroke

    Early features include: loss of grey-white matter differentiation, and hypoattenuation of deep nuclei: lentiform nucleus changes seen as early as 1 hour after occlusion, visible[radiopaedia.org] Asymmetric step length is a common abnormal gait pattern in hemiplegic stroke patients.[ncbi.nlm.nih.gov] All patients except one had small infarcts, with the majority of them in the basal ganglia and subcortical white matter regions.[ncbi.nlm.nih.gov]

  • Huntington's Disease

    Both deep grey matter and to a lesser degree white matter are involved in HD.[radiopaedia.org] […] in the basal ganglia, drugs such as levodopa, neuroleptics and oral contraception, various metabolic and endocrinological disorders such as hyperthyroidism, hypo/hyperparathyroidism[movementdisorders.org] Gait abnormalities: Gait abnormalities start developing in the intermediate stage of the disease. The gait is irregular and unsteady.[symptoma.com]

  • Hallervorden-Spatz Syndrome

    Brain stem nuclei had similar changes. The high signal intensity lesions in the deep cerebral white matter and dentate nuclei were unchanged.[ajnr.org] The early onset childhood group had uniform presentation with developmental delay, recurrent falls, gait abnormalities, cognitive deterioration and dystonia.[ncbi.nlm.nih.gov] “limbic ‏ الصفحة 32 - Obsessive-compulsive and other behavioural changes with bilateral basal ganglia lesions.[books.google.com]

  • CADASIL Syndrome

    MR imaging lesion load correlated with some clinical features including stroke and dementia, whereas depression is more common in individuals with deep white matter changes[ajnr.org] […] affecting the anterior temporal pole, and basal ganglia; focal hypointensities on T1 (lacunar infarcts) and lesions suggestive of microhemorrhages in SWI and gradient-echo[mdsabstracts.org] This can result in an unsteady and wide based gait or sometimes an abnormal gait due to small steps. Should antiplatelet agents such as Aspirin be prescribed in CADASIL?[cambridgestroke.com]

  • Binswanger Disease

    OBJECTIVES: To analyse the diagnostic and prognostic value of periventricular hyperintensity (PVH) and deep white matter hyperintensity (DWMH) magnetic resonance imaging ([ncbi.nlm.nih.gov] In most patients, multiple lacunar infarcts are also present in the basal ganglia, thalami, and pons 3.[radiopaedia.org] The abnormality of gait that may occur in patients with subcortical arteriosclerotic encephalopathy is described in 12 patients in whom difficulty walking was the presenting[medigoo.com]

  • Primary Progressive Multiple Sclerosis

    Consistent with this reduction, we showed that changes in diffusion indices of tissue damage within major clinically relevant white matter (corpus callosum and corticospinal[ncbi.nlm.nih.gov] These lesions most commonly affect the white matter in the optic nerve, brain stem, basal ganglia, and spinal cord, or white matter tracts close to the lateral ventricles.[en.wikipedia.org] A key symptom associated with PPMS is difficulty walking. This may result from the damage to the spinal cord that occurs with PPMS.[medicalnewstoday.com]

  • Adult Polyglucosan Body Disease

    MRI of the brain and spinal cord reveals the following: Paraventricular, subcortical, and deep white matter changes that may include involvement of the upper pons, superior[ncbi.nlm.nih.gov] […] involving temporal pole, external capsule, basal ganglia and/or pons Autosomal dominant inheritance of migraine, early stroke and dementia1 100 CADASIL Clinical suspicion[docplayer.it] Progressive spasticity and weakness are also present due to upper and lower motor neuron involvement and patients have difficulty walking.[orpha.net]

  • Basal Ganglia Mass Lesion

    These white matter changes are classified according to Fazekas: Mild - punctate WMLs: Fazekas I) Moderate - confluent WMLs: Fazekas II - in the deep white matter can be considered[radiologyassistant.nl] As a result, patients often develop abnormal gait and stances to compensate.[nba.uth.tmc.edu] Acute movement disorder with bilateral basal ganglia lesions in diabetic uremia.[annalsofian.org]

  • Machado-Joseph Disease

    Magnetic resonance spectroscopy (MRS) of the deep white matter has demonstrated changes indicative of axonal dysfunction, although MRI in the same study did not reveal any[symptoma.com] Abnormalities of basal ganglia, thalamus, spinal cord, dorsal root ganglia, and sensory peripheral nerves are more variable.[ncbi.nlm.nih.gov] walking due to muscle spasms (spastic gait) Poor reflexes Type III (MJD-III) Between 40-70 years of age Symptoms slowly worsen over time Muscle twitching Numbness, tingling[rarediseases.about.com]

  • Autosomal Dominant Progressive External Ophthalmoplegia Type 6

    Magnetic resonance imaging of the brain revealed volume loss and periventricular and deep white matter signal change; however, these features were generalized rather than[jamanetwork.com] Progressive external ophthalmoplegia Obstructive sleep apnea Exertional dyspnea Generalized amyotrophy Sleep apnea Difficulty walking Apnea Dyspnea Tremor Elevated serum[mendelian.co] ganglia lesion Arthralgia Hypothyroidism Recurrent respiratory infections Optic nerve glioma Heterogeneous Inguinal freckling Spinal neurofibromas Hypospadias Congestive[mendelian.co]

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