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21 Possible Causes for Abnormal Gait, Coarse Tremor, Deep White Matter Changes

  • Primary Progressive Multiple Sclerosis

    Consistent with this reduction, we showed that changes in diffusion indices of tissue damage within major clinically relevant white matter (corpus callosum and corticospinal[ncbi.nlm.nih.gov] A key symptom associated with PPMS is difficulty walking. This may result from the damage to the spinal cord that occurs with PPMS.[medicalnewstoday.com] People with PPMS may have trouble with balance and coordination or have difficulty walking.[healthline.com]

  • Hereditary Cerebellar Degeneration

    Axial T2 image shows signal change affecting the deep cerebellar white matter ( arrow s).[ajnr.org] Cerebro-cerebellar dysfunction presents with disturbances in carrying out voluntary movements, including intention tremor (coarse trembling, accentuated over the execution[psychology.wikia.com] Clinical signs are varied, with some patients having limb and gait ataxia along with episodic headaches or nausea, and others having gait ataxia, speech difficulty, and abnormal[encyclopedia.com]

  • Huntington's Disease

    Both deep grey matter and to a lesser degree white matter are involved in HD.[radiopaedia.org] Gait abnormalities: Gait abnormalities start developing in the intermediate stage of the disease. The gait is irregular and unsteady.[symptoma.com] He had depression, poor cognitive function, choreiform movements, difficulty pronouncing words, and difficulty walking.[ncbi.nlm.nih.gov]

  • Binswanger Disease

    OBJECTIVES: To analyse the diagnostic and prognostic value of periventricular hyperintensity (PVH) and deep white matter hyperintensity (DWMH) magnetic resonance imaging ([ncbi.nlm.nih.gov] […] low-frequency ( tremor often of irregular, coarse rhythm that is present during both rest and intentional movements and typically follows cerebellar outflow pathway lesions[strokecenter.org] The abnormality of gait that may occur in patients with subcortical arteriosclerotic encephalopathy is described in 12 patients in whom difficulty walking was the presenting[medigoo.com]

  • Olivopontocerebellar Atrophy

    Evaluation of Postmortem MR Imaging Findings The presence of atrophy and signal-intensity change of cerebellar cortices, deep white matter and dentate nucleus regions was[ajnr.org] Dysfunctions of the cerebellum may lead to an abnormal gait or other motor function problems.[news-medical.net] There may also be problems with balance, slurring of speech, and difficulty walking.[nlm.nih.gov]

  • Adult Polyglucosan Body Disease

    MRI of the brain and spinal cord reveals the following: Paraventricular, subcortical, and deep white matter changes that may include involvement of the upper pons, superior[ncbi.nlm.nih.gov] In her limbs she had a coarse resting tremor, most marked in the right arm with no associated cerebellar signs but cogwheeling rigidity and bradykinesia.[jnnp.bmj.com] Progressive spasticity and weakness are also present due to upper and lower motor neuron involvement and patients have difficulty walking.[orpha.net]

  • Toxic Encephalopathy

    white matter changes may be seen, with the appearance of hyperintensity on T2 sequences in the region of internal capsule, corona radiata, and splenium of corpus callosum[neurologyindia.com] Other symptoms that suggest lack of brain control include incoordination of movements, difficulty walking, problems with vision and speech.[healthcare-online.org] There may be incoordination and difficulty walking (ataxia) or there may be abnormalities with vision and eye movement.[emedicinehealth.com]

  • Autosomal Dominant Spastic Paraplegia Type 8

    Enlarged ventricles, a thin corpus callosum, and periventricular white matter changes may also be present.[disorders.eyes.arizona.edu] A coarse, irregular action tremor, often seen in paraproteinemic neuropathy, may occur and may be related to a CNS equivalent mimicking neuroradiologically MS.[neuroweb.us] The father, brother, and uncle were both asymptomatic while the grandfather was wheelchairbound and the mother had abnormal gait.[omicsonline.org]

  • Basal Ganglia Mass Lesion

    These white matter changes are classified according to Fazekas: Mild - punctate WMLs: Fazekas I) Moderate - confluent WMLs: Fazekas II - in the deep white matter can be considered[radiologyassistant.nl] […] low-frequency ( tremor often of irregular, coarse rhythm that is present during both rest and intentional movements and typically follows cerebellar outflow pathway lesions[strokecenter.org] As a result, patients often develop abnormal gait and stances to compensate.[nba.uth.tmc.edu]

  • Spastic Ataxia with Congenital Miosis

    , early executive dysfunction, cerebral infarction and/or deep white matter changes on neuroimaging Dementia: Early personality changes, apathy, disinhibition, compulsive[quizlet.com] : coarse, cogwhelling, lead-pipe rigidity EPS symptoms: Sialorrhea (excess salivation), Opisthotonus (arched back and lying position of body with feet and hands on bed; caused[flashcardmachine.com] The neuropsychiatric manifestations are varied but typically include alterations of consciousness, eye movement abnormalities, and gait and balance disorders.[online.epocrates.com]

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