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21 Possible Causes for Abnormal Gait, Coarse Tremor, Deep White Matter Changes

  • Primary Progressive Multiple Sclerosis

    Consistent with this reduction, we showed that changes in diffusion indices of tissue damage within major clinically relevant white matter (corpus callosum and corticospinal[] A key symptom associated with PPMS is difficulty walking. This may result from the damage to the spinal cord that occurs with PPMS.[] People with PPMS may have trouble with balance and coordination or have difficulty walking.[]

  • Hereditary Cerebellar Degeneration

    Axial T2 image shows signal change affecting the deep cerebellar white matter ( arrow s).[] Cerebro-cerebellar dysfunction presents with disturbances in carrying out voluntary movements, including intention tremor (coarse trembling, accentuated over the execution[] Clinical signs are varied, with some patients having limb and gait ataxia along with episodic headaches or nausea, and others having gait ataxia, speech difficulty, and abnormal[]

  • Huntington's Disease

    Both deep grey matter and to a lesser degree white matter are involved in HD.[] Gait abnormalities: Gait abnormalities start developing in the intermediate stage of the disease. The gait is irregular and unsteady.[] He had depression, poor cognitive function, choreiform movements, difficulty pronouncing words, and difficulty walking.[]

  • Binswanger Disease

    OBJECTIVES: To analyse the diagnostic and prognostic value of periventricular hyperintensity (PVH) and deep white matter hyperintensity (DWMH) magnetic resonance imaging ([] […] low-frequency ( tremor often of irregular, coarse rhythm that is present during both rest and intentional movements and typically follows cerebellar outflow pathway lesions[] The abnormality of gait that may occur in patients with subcortical arteriosclerotic encephalopathy is described in 12 patients in whom difficulty walking was the presenting[]

  • Olivopontocerebellar Atrophy

    Evaluation of Postmortem MR Imaging Findings The presence of atrophy and signal-intensity change of cerebellar cortices, deep white matter and dentate nucleus regions was[] Dysfunctions of the cerebellum may lead to an abnormal gait or other motor function problems.[] There may also be problems with balance, slurring of speech, and difficulty walking.[]

  • Adult Polyglucosan Body Disease

    MRI of the brain and spinal cord reveals the following: Paraventricular, subcortical, and deep white matter changes that may include involvement of the upper pons, superior[] In her limbs she had a coarse resting tremor, most marked in the right arm with no associated cerebellar signs but cogwheeling rigidity and bradykinesia.[] Progressive spasticity and weakness are also present due to upper and lower motor neuron involvement and patients have difficulty walking.[]

  • Toxic Encephalopathy

    white matter changes may be seen, with the appearance of hyperintensity on T2 sequences in the region of internal capsule, corona radiata, and splenium of corpus callosum[] Other symptoms that suggest lack of brain control include incoordination of movements, difficulty walking, problems with vision and speech.[] There may be incoordination and difficulty walking (ataxia) or there may be abnormalities with vision and eye movement.[]

  • Autosomal Dominant Spastic Paraplegia Type 8

    Enlarged ventricles, a thin corpus callosum, and periventricular white matter changes may also be present.[] A coarse, irregular action tremor, often seen in paraproteinemic neuropathy, may occur and may be related to a CNS equivalent mimicking neuroradiologically MS.[] The father, brother, and uncle were both asymptomatic while the grandfather was wheelchairbound and the mother had abnormal gait.[]

  • Basal Ganglia Mass Lesion

    These white matter changes are classified according to Fazekas: Mild - punctate WMLs: Fazekas I) Moderate - confluent WMLs: Fazekas II - in the deep white matter can be considered[] […] low-frequency ( tremor often of irregular, coarse rhythm that is present during both rest and intentional movements and typically follows cerebellar outflow pathway lesions[] As a result, patients often develop abnormal gait and stances to compensate.[]

  • Spastic Ataxia with Congenital Miosis

    , early executive dysfunction, cerebral infarction and/or deep white matter changes on neuroimaging Dementia: Early personality changes, apathy, disinhibition, compulsive[] : coarse, cogwhelling, lead-pipe rigidity EPS symptoms: Sialorrhea (excess salivation), Opisthotonus (arched back and lying position of body with feet and hands on bed; caused[] The neuropsychiatric manifestations are varied but typically include alterations of consciousness, eye movement abnormalities, and gait and balance disorders.[]

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