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96 Possible Causes for Abnormal Gait, Cognitive Defect, Deep White Matter Changes

  • Binswanger Disease

    OBJECTIVES: To analyse the diagnostic and prognostic value of periventricular hyperintensity (PVH) and deep white matter hyperintensity (DWMH) magnetic resonance imaging ([ncbi.nlm.nih.gov] The abnormality of gait that may occur in patients with subcortical arteriosclerotic encephalopathy is described in 12 patients in whom difficulty walking was the presenting[medigoo.com] These cases can be distinguished from general paralysis first by the stability of their deficits, secondly by the peculiar development of the cognitive defect (decrease of[www2.psykl.med.tum.de]

  • Stroke

    Early features include: loss of grey-white matter differentiation, and hypoattenuation of deep nuclei: lentiform nucleus changes seen as early as 1 hour after occlusion, visible[radiopaedia.org] Asymmetric step length is a common abnormal gait pattern in hemiplegic stroke patients.[ncbi.nlm.nih.gov] ., face drooping, hemiparesis/hemiplegia, inability to lift ipsilateral arm or abnormal gait Contralateral sensory loss Contralateral homonymous hemianopia Dysphasia Dysphagia[symptoma.com]

  • Primary Progressive Multiple Sclerosis

    Consistent with this reduction, we showed that changes in diffusion indices of tissue damage within major clinically relevant white matter (corpus callosum and corticospinal[ncbi.nlm.nih.gov] A key symptom associated with PPMS is difficulty walking. This may result from the damage to the spinal cord that occurs with PPMS.[medicalnewstoday.com] People with PPMS may have trouble with balance and coordination or have difficulty walking.[healthline.com]

  • Huntington's Disease

    Both deep grey matter and to a lesser degree white matter are involved in HD.[radiopaedia.org] Gait abnormalities: Gait abnormalities start developing in the intermediate stage of the disease. The gait is irregular and unsteady.[symptoma.com] In addition to motor symptoms and cognitive deterioration, neuropsychiatric symptoms comprise part of the Huntington’s disease phenotype. 1 – 3 The genetic defect underlying[dx.doi.org]

  • Creutzfeldt Jakob Disease

    Some other features, such as the presence of abnormal hyperintensity in the periaqueductal gray matter and posterior deep white matter tracts, were also common, and although[ajnr.org] People with CJD will have ataxia, or difficulty controlling body movements, abnormal gait, speech, and dementia. It is always fatal, and there is no cure.[medicalnewstoday.com] For sCJDMV1 patients, ataxia rather than cognitive decline as well as sensory defect may be more common at onset.[doi.org]

  • Normal Pressure Hydrocephalus

    White matter changes (WMC) INPH is known to be associated with deep white matter changes (DWMC) and smooth periventricular hyperintensity (PVH) [ 51 ] on MRI ( Figure 2B )[intechopen.com] Other symptoms of NPH are urinary incontinence, and abnormal gait.[symptoma.com] White-matter changes: A distinction is drawn between periventricular and “deepwhite matter changes ( e49, e50 ); only the former are considered a sign of NPH.[ncbi.nlm.nih.gov]

  • Subacute Sclerosing Panencephalitis

    Later, high signal changes in deep white matter and severe cerebral atrophy were observed.[doi.org] Soon after, she developed difficulty walking and often talked to a “friend” who was not present.[pediatrics.aappublications.org] This is caused by persistent defective measles virus infection.[ncbi.nlm.nih.gov]

  • Alcohol Dementia

    The CT showed prominent sulci and gyri with deep white matter changes. There were no other abnormalities.[gponline.com] This disorder is characterized by paralysis of eye movements, abnormal stance and gait, and markedly deranged mental function.[newenglandnightingales.com] Activity Due to gait abnormalities, unassisted ambulation is discouraged during the initial phase of treatment.[dementiatoday.net]

  • Hyponatremia

    In the brain MRI, millimeter-sized chronic microangiopathic ischemic signal changes were observed in the periventricular deep white matter; no mass image was seen in the pituitary[reumatologiaclinica.org] walking.[casesjournal.biomedcentral.com] […] than those observed in patients with blood alcohol levels of 0.05%; these gait abnormalities corrected when the serum sodium levels returned to normal.[cjasn.asnjournals.org]

  • Dementia

    It may be particularly related to frontal deep white matter lesions. 16 Cognitive and behavioral changes in SVD are due to disruption of the frontal cortico-subcortical circuit[doi.org] walking experiencing behaviour changes that may escalate and include aggression.[web.archive.org] In advanced AD pathology, synaptic dysfunction is another structural defect associated with a decline in memory ( 35 Terry RD.[doi.org]

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