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172 Possible Causes for Abnormal Gait, Deep White Matter Changes

  • Stroke

    Early features include: loss of grey-white matter differentiation, and hypoattenuation of deep nuclei: lentiform nucleus changes seen as early as 1 hour after occlusion, visible[radiopaedia.org] Asymmetric step length is a common abnormal gait pattern in hemiplegic stroke patients.[ncbi.nlm.nih.gov] ., face drooping, hemiparesis/hemiplegia, inability to lift ipsilateral arm or abnormal gait Contralateral sensory loss Contralateral homonymous hemianopia Dysphasia Dysphagia[symptoma.com]

  • Pineal Gland Cyst

    Today I received my results stating I have a few like foci of increased T2 signal in the deep periventricular white matter regions.[healthcaremagic.com] These are compatible with ischemic/gliotic changes, or could represent the sequela of migraine headaches. It also states I have a small simple pineal cyst ...[healthcaremagic.com]

  • Binswanger Disease

    OBJECTIVES: To analyse the diagnostic and prognostic value of periventricular hyperintensity (PVH) and deep white matter hyperintensity (DWMH) magnetic resonance imaging ([ncbi.nlm.nih.gov] The abnormality of gait that may occur in patients with subcortical arteriosclerotic encephalopathy is described in 12 patients in whom difficulty walking was the presenting[medigoo.com] Extrapyramidal disease Gait disturbance Low back pain Progressive encephalopathy Pseudobulbar signs Rigidity Abnormality of the skeletal system Low back pain Congenital anomaly[familydiagnosis.com]

  • Primary Progressive Multiple Sclerosis

    Consistent with this reduction, we showed that changes in diffusion indices of tissue damage within major clinically relevant white matter (corpus callosum and corticospinal[ncbi.nlm.nih.gov] A key symptom associated with PPMS is difficulty walking. This may result from the damage to the spinal cord that occurs with PPMS.[medicalnewstoday.com] People with PPMS may have trouble with balance and coordination or have difficulty walking.[healthline.com]

  • Lafora Disease

    matter signal, Deep frontoparietal cerebral changes at 10 years of age Child onset: Weakness Clinical Weakness: Proximal; Symmetric Muscle size: Calf hypertrophy Subgroup[neuromuscular.wustl.edu] Lafora disease causes seizures, muscle spasms, difficulty walking, dementia, and eventually death.[diseaseinfosearch.org] About Lafora Disease Lafora Disease (LD) is a rare, progressive, autosomal recessive neurodegenerative disorder characterized by intractable seizures, difficulty walking,[prnewswire.com]

  • CADASIL Syndrome

    MR imaging lesion load correlated with some clinical features including stroke and dementia, whereas depression is more common in individuals with deep white matter changes[ajnr.org] This can result in an unsteady and wide based gait or sometimes an abnormal gait due to small steps. Should antiplatelet agents such as Aspirin be prescribed in CADASIL?[cambridgestroke.com] Typical neuroradiological findings on magnetic resonance imaging (MRI): multifocal and bilateral FLAIR/T2 hyperintensities in the periventricular and deep white matter, with[doi.org]

  • Hallervorden-Spatz Syndrome

    Brain stem nuclei had similar changes. The high signal intensity lesions in the deep cerebral white matter and dentate nuclei were unchanged.[ajnr.org] The early onset childhood group had uniform presentation with developmental delay, recurrent falls, gait abnormalities, cognitive deterioration and dystonia.[ncbi.nlm.nih.gov] Usually presents with gait abnormalities. Leads to loss of ambulation within 10-15 years of onset. Extrapyramidal signs including dystonia and rigidity.[genetics4medics.com]

  • Adult Polyglucosan Body Disease

    MRI of the brain and spinal cord reveals the following: Paraventricular, subcortical, and deep white matter changes that may include involvement of the upper pons, superior[ncbi.nlm.nih.gov] Progressive spasticity and weakness are also present due to upper and lower motor neuron involvement and patients have difficulty walking.[orpha.net] A brain MRI showed diffuse white matter and ischemic changes in bilateral deep parietal area, and a focal signal intensity increase in the left dentate nucleus of cerebellum[synapse.koreamed.org]

  • Machado-Joseph Disease

    Magnetic resonance spectroscopy (MRS) of the deep white matter has demonstrated changes indicative of axonal dysfunction, although MRI in the same study did not reveal any[symptoma.com] walking due to muscle spasms (spastic gait) Poor reflexes Type III (MJD-III) Between 40-70 years of age Symptoms slowly worsen over time Muscle twitching Numbness, tingling[rarediseases.about.com] The majority of patients develop gait abnormalities and a series of other neurological symptoms between the ages of 20 and 40.[news-medical.net]

  • Huntington's Disease

    Both deep grey matter and to a lesser degree white matter are involved in HD.[radiopaedia.org] Gait abnormalities: Gait abnormalities start developing in the intermediate stage of the disease. The gait is irregular and unsteady.[symptoma.com] He had depression, poor cognitive function, choreiform movements, difficulty pronouncing words, and difficulty walking.[ncbi.nlm.nih.gov]

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