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10 Possible Causes for Abnormal Gait, Deep White Matter Changes, Deglutition Disorder

  • Stroke

    Early features include: loss of grey-white matter differentiation, and hypoattenuation of deep nuclei: lentiform nucleus changes seen as early as 1 hour after occlusion, visible[radiopaedia.org] Asymmetric step length is a common abnormal gait pattern in hemiplegic stroke patients.[ncbi.nlm.nih.gov] ., face drooping, hemiparesis/hemiplegia, inability to lift ipsilateral arm or abnormal gait Contralateral sensory loss Contralateral homonymous hemianopia Dysphasia Dysphagia[symptoma.com]

  • Primary Progressive Multiple Sclerosis

    Consistent with this reduction, we showed that changes in diffusion indices of tissue damage within major clinically relevant white matter (corpus callosum and corticospinal[ncbi.nlm.nih.gov] A key symptom associated with PPMS is difficulty walking. This may result from the damage to the spinal cord that occurs with PPMS.[medicalnewstoday.com] People with PPMS may have trouble with balance and coordination or have difficulty walking.[healthline.com]

  • CADASIL Syndrome

    MR imaging lesion load correlated with some clinical features including stroke and dementia, whereas depression is more common in individuals with deep white matter changes[ajnr.org] This can result in an unsteady and wide based gait or sometimes an abnormal gait due to small steps. Should antiplatelet agents such as Aspirin be prescribed in CADASIL?[cambridgestroke.com] Typical neuroradiological findings on magnetic resonance imaging (MRI): multifocal and bilateral FLAIR/T2 hyperintensities in the periventricular and deep white matter, with[doi.org]

  • Diffuse Cerebral Sclerosis of Schilder

    change in the deep white matter.[doi.org] The most common symptoms are usually behavioral changes such as abnormal withdrawal or aggression, poor memory, and poor school performance.[ninds.nih.gov] […] disorders, leg stiffness or weakness, abnormalities of sphincter control, and sexual dysfunction, with or without adrenal insufficiency or cognitive or behavioral deficits[ncbi.nlm.nih.gov]

  • Creutzfeldt Jakob Disease

    Some other features, such as the presence of abnormal hyperintensity in the periaqueductal gray matter and posterior deep white matter tracts, were also common, and although[ajnr.org] People with CJD will have ataxia, or difficulty controlling body movements, abnormal gait, speech, and dementia. It is always fatal, and there is no cure.[medicalnewstoday.com] Symptoms may include behavior changes, confusion, memory problems, stiff muscles, loss of feeling in arms, legs or face, loss of balance, difficulty walking, muscle spasms[nj.gov]

  • Huntington's Disease

    Both deep grey matter and to a lesser degree white matter are involved in HD.[radiopaedia.org] Gait abnormalities: Gait abnormalities start developing in the intermediate stage of the disease. The gait is irregular and unsteady.[symptoma.com] It only provides information about intraluminal pressure and thus it is difficult to study functional details of esophageal motility disorders.[ncbi.nlm.nih.gov]

  • Ataxia Telangiectasia

    Occasionally, lesions that are consistent with small vessel ischemic or degenerative changes have been noted in the deep white matter of the cerebral hemispheres.[appliedradiology.com] The records of all patients seen at the Ataxia-Telangiectasia Clinical Center from July 1, 1995 to April 1, 1997 were reviewed to determine age of onset of gait abnormality[ncbi.nlm.nih.gov] Treatments that improve nutritional status and minimize the risk of aspiration for patients with chronic progressive disorders are salutary[ 15 – 20 ].[doi.org]

  • Globoid Cell Leukodystrophy

    CONCLUSION: Cerebellar white matter and deep gray matter involvement are present only in early-onset GLD.[ncbi.nlm.nih.gov] They may include: Progressive loss of vision Difficulty walking (ataxia) Decline in thinking skills Loss of manual dexterity Muscle weakness As a general rule, the younger[mayoclinic.org] In some cases, such abnormalities may already be present before the surgery as a consequence of SWS.[rarediseases.org]

  • Familial Infantile Bilateral Striatal Necrosis

    […] eyes, prominent nasal bridge, micrognathia), seizures and abnormalities of brain morphology (hypomyelinating white matter changes, cerebral atrophy).[mendelian.co] : oftalmoplegy, look alterations, nystagmus lactic acidosis can lead to impairment of respiratory and kidney function Deglutition troubles(paralysis) Dystonia Rigidity, tremor[flipper.diff.org] Substantia nigra and other portions of the basal ganglia did not reveal any abnormality.[jpgmonline.com]

  • Neonatal Hypotonia

    white matter changes can be seen in Lowe syndrome, aperoxisomal defectAbnormalities in the corpus callosum may occur in Smith- Lemli-Opitz syndromeHeterotopias may be seen[slideshare.net] gait, or joint deformity.[lermagazine.com] disorders and arthrogryposis can alert clinicians and may offer clues for prenatal diagnosis of PWS. 6 A possible diagnosis of PWS should be considered for all neonates with[nature.com]

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