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35 Possible Causes for Abnormal Gait, Deep White Matter Changes, Facial Numbness

  • Stroke

    Early features include: loss of grey-white matter differentiation, and hypoattenuation of deep nuclei: lentiform nucleus changes seen as early as 1 hour after occlusion, visible[radiopaedia.org] A 48-year-old man presented with acute onset of left facial numbness, ataxic gait and double vision.[ncbi.nlm.nih.gov] Asymmetric step length is a common abnormal gait pattern in hemiplegic stroke patients.[ncbi.nlm.nih.gov]

  • Primary Progressive Multiple Sclerosis

    Consistent with this reduction, we showed that changes in diffusion indices of tissue damage within major clinically relevant white matter (corpus callosum and corticospinal[ncbi.nlm.nih.gov] Facial numbness and weakness are also common.[medical-dictionary.thefreedictionary.com] A key symptom associated with PPMS is difficulty walking. This may result from the damage to the spinal cord that occurs with PPMS.[medicalnewstoday.com]

  • Binswanger Disease

    OBJECTIVES: To analyse the diagnostic and prognostic value of periventricular hyperintensity (PVH) and deep white matter hyperintensity (DWMH) magnetic resonance imaging ([ncbi.nlm.nih.gov] There may be a localized area of the body, such as a hand or the facial muscles, that is weakened or the person may have a numb area somewhere on their body.[dementiacarecentral.com] The abnormality of gait that may occur in patients with subcortical arteriosclerotic encephalopathy is described in 12 patients in whom difficulty walking was the presenting[medigoo.com]

  • Brain Stem Disorder

    matter changes (6/7), cortical atrophy (3/7), small corpus callosum (4/7) and small brain stem (2/7) 19. top contents next Involvement of the CNS may also be observed in[mrineonatalbrain.com] Typical symptoms include eye pain and vision disturbances; speech disorders; facial numbness or pain; incoordination of gait and of the limbs; spasticity, weakness, and increased[britannica.com] As a result, patients often develop abnormal gait and stances to compensate.[nba.uth.tmc.edu]

  • Mucopolysaccharidosis 6

    matter, 12, 15 though signal-intensity abnormalities may appear in all parts of the cerebrum, affecting various brain lobes and subcortical regions. 19, 24 Concerning deep[ajnr.org] […] within the joints Mild to severe chronic pain Numbness, tingling Loss of hearing (and learning difficulties as a result) Enlarged spleen and/or liver Pulmonary and cardiac[patientworthy.com] Affected individuals may develop pain, especially of the joints and hip, spinal cord compression, an abnormal manner of walking (gait), or difficulty walking.[rarediseases.org]

  • Vascular Dementia

    Several pathogenic mechanisms appear implicated in the causation the deep white matter changes of Binswanger's disease, and hypoxia-ischemia resulting from watershed injury[web.archive.org] There may be a localized area of the body, such as a hand or the facial muscles, that is weakened or the person may have a numb area somewhere on their body.[dementiacarecentral.com] “Some people may also have issues with central functions like bladder control or developing an abnormal gait when they’re walking.”[bhf.org.uk]

  • Posterior Cerebral Artery Occlusion with Infarction

    This is often associated with diffuse periventricular demyelination secondary to ischaemia in the deep white matter, which causes patchy or diffuse changes, known as ‘leukoaraiosis[aibolita.com] PICA territory infarct result in a Wallenberg's syndrome characterized by nausea, vomiting, and vertigo, ipsilateral facial numbness, weakness of the ipsilateral soft palate[neuroradiologycases.com] Grasp reflex, frontal lobe behavioural abnormalities and left hemineglect can also be seen if the prefrontal cortex and non-dominant association cortex are involved.[physio-pedia.com]

  • Spinal Demyelination

    white matter ischemia radiotherapy changes[radiopaedia.org] Other less common symptoms of NMO include vertigo, facial numbness, headache, and tremors [4] .[sickkids.ca] This can causes symptoms like numbness and tingling at one end of the spectrum and difficulty walking or doing every-day tasks at the other end.[health.clevelandclinic.org]

  • Susac Syndrome

    In addition, high-signal-intensity changes are usually seen in the periventricular white matter and the deep gray matter [ 1 ].[ajronline.org] This was accompanied by nausea, vertigo, left facial numbness, and dysarthria that lasted 3 hours.[n.neurology.org] Herein we describe a 25-year-old previously healthy woman who presented at 20 weeks' gestation with symptoms of confusion, difficulty walking, and vision and hearing loss.[ncbi.nlm.nih.gov]

  • Migrainous Stroke

    MRI may demonstrate T2 hyperintensities in the white matter of the centrum semiovale, not dissimilar to small vessel deep white matter ischemic change.[radiopaedia.org] Stroke and migraine symptoms that may be similar include: Severe headache Facial numbness Numbness in the extremities or face Dizziness A main difference between the symptoms[medicinenet.com] walking Causes Migrainous infarctions occur primarily in younger women who have a history of migraine with aura.[verywell.com]

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