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111 Possible Causes for Abnormal Gait, Deep White Matter Changes, Hyperreflexia

  • Stroke

    Early features include: loss of grey-white matter differentiation, and hypoattenuation of deep nuclei: lentiform nucleus changes seen as early as 1 hour after occlusion, visible[radiopaedia.org] Asymmetric step length is a common abnormal gait pattern in hemiplegic stroke patients.[ncbi.nlm.nih.gov] An examination showed decreased strength on the right side, with hyperreflexia and an up-going plantar response.[ncbi.nlm.nih.gov]

  • Primary Progressive Multiple Sclerosis

    Consistent with this reduction, we showed that changes in diffusion indices of tissue damage within major clinically relevant white matter (corpus callosum and corticospinal[ncbi.nlm.nih.gov] A key symptom associated with PPMS is difficulty walking. This may result from the damage to the spinal cord that occurs with PPMS.[medicalnewstoday.com] Affected individuals may have tremors, muscle stiffness (spasticity), exaggerated reflexes (hyperreflexia), weakness or partial paralysis of the muscles of the limbs, difficulty[icdlist.com]

  • Hallervorden-Spatz Syndrome

    Brain stem nuclei had similar changes. The high signal intensity lesions in the deep cerebral white matter and dentate nuclei were unchanged.[ajnr.org] The early onset childhood group had uniform presentation with developmental delay, recurrent falls, gait abnormalities, cognitive deterioration and dystonia.[ncbi.nlm.nih.gov] Neurologically, opisthotonus, rigidity of extremities, dystonia, hyperreflexia, profound emaciation, and bilaterally positive Babinski signs were present.[ncbi.nlm.nih.gov]

  • Huntington's Disease

    Both deep grey matter and to a lesser degree white matter are involved in HD.[radiopaedia.org] Gait abnormalities: Gait abnormalities start developing in the intermediate stage of the disease. The gait is irregular and unsteady.[symptoma.com] He had depression, poor cognitive function, choreiform movements, difficulty pronouncing words, and difficulty walking.[ncbi.nlm.nih.gov]

  • Subacute Sclerosing Panencephalitis

    Later, high signal changes in deep white matter and severe cerebral atrophy were observed.[doi.org] Soon after, she developed difficulty walking and often talked to a “friend” who was not present.[pediatrics.aappublications.org] The symptoms of SSPE can include the following: Coma Death Seizures Irritability Dementia Blindness Spasticity Memory loss Optic atrophy Hyperthermia Unsteady gait Abnormal[disabled-world.com]

  • Infantile Neuroaxonal Dystrophy

    In one patient (juvenile case) with lesions in the deep frontal white matter, an elevated diffusion pattern was evident.[ajnr.org] Clinical Onset before age 20 years Psychomotor regression Gait abnormalities Prominent expressive language difficulties Psychiatric/behavioral abnormalities including autistic-like[ncbi.nlm.nih.gov] […] weakness 0003324 Gliosis 0002171 Global developmental delay 0001263 Hearing impairment Deafness Hearing defect [ more ] 0000365 Hyperactivity More active than typical 0000752 Hyperreflexia[rarediseases.info.nih.gov]

  • Binswanger Disease

    OBJECTIVES: To analyse the diagnostic and prognostic value of periventricular hyperintensity (PVH) and deep white matter hyperintensity (DWMH) magnetic resonance imaging ([ncbi.nlm.nih.gov] The abnormality of gait that may occur in patients with subcortical arteriosclerotic encephalopathy is described in 12 patients in whom difficulty walking was the presenting[medigoo.com] In addition, focal neurological deficits are commonly observed, most prominent being those involving the upper motor neurons (UMNs) - muscle rigidity, hyperreflexia (often[symptoma.com]

  • Autosomal Dominant Spastic Paraplegia Type 8

    Enlarged ventricles, a thin corpus callosum, and periventricular white matter changes may also be present.[disorders.eyes.arizona.edu] The father, brother, and uncle were both asymptomatic while the grandfather was wheelchairbound and the mother had abnormal gait.[omicsonline.org] Symptoms include hyperreflexia, extensor plantar responses, degeneration of the lateral corticospinal tracts, decreased vibratory sense in the lower limbs, pes cavus and atrophy[cags.org.ae]

  • CARASIL

    Individuals with CARASIL may develop a variety of symptoms relating to white matter involvement or leukoaraiosis (changes in deep white matter in the brain, which are observed[rarediseases.org] 0007204 Dysarthria Difficulty articulating speech 0001260 Gait disturbance Abnormal gait Abnormal walk Impaired gait [ more ] 0001288 Hyperreflexia Increased reflexes 0001347[rarediseases.info.nih.gov] Neurological symptoms include pseudobulbar palsy, hyperreflexia, vestibular symptoms, and ophthalmoplegia.[orpha.net]

  • Adult-Onset Autosomal Recessive Cerebellar Ataxia

    Axial T2 image shows signal change affecting the deep cerebellar white matter ( arrow s).[ajnr.org] Autosomal recessive, X-linked, autosomal dominant Cerebellar ataxias are a highly heterogeneous group of genetic disorders distinguished by abnormal wide-based gait, irregular[centogene.com] : Clinical features Age of onset - 43-56 years Slow progression Gait and limb ataxia Dysarthria Occular dysmetria Slow saccades Decreased vibratory sense below the knees Hyperreflexia[emedicine.medscape.com]

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