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145 Possible Causes for Abnormal Gait, Deep White Matter Changes, Irritability

  • Binswanger Disease

    OBJECTIVES: To analyse the diagnostic and prognostic value of periventricular hyperintensity (PVH) and deep white matter hyperintensity (DWMH) magnetic resonance imaging ([ncbi.nlm.nih.gov] The abnormality of gait that may occur in patients with subcortical arteriosclerotic encephalopathy is described in 12 patients in whom difficulty walking was the presenting[medigoo.com] […] forgetfulness of Alzheimer's disease), changes in speech, an unsteady gait, clumsiness or frequent falls, changes in personality or mood (most likely in the form of apathy, irritability[ninds.nih.gov]

  • Huntington's Disease

    Both deep grey matter and to a lesser degree white matter are involved in HD.[radiopaedia.org] Gait abnormalities: Gait abnormalities start developing in the intermediate stage of the disease. The gait is irregular and unsteady.[symptoma.com] In multivariate regression analyses, both suicidal ideation and suicidal behavior were associated with a depressed mood, and to a lesser extend to irritability.[ncbi.nlm.nih.gov]

  • Creutzfeldt Jakob Disease

    Some other features, such as the presence of abnormal hyperintensity in the periaqueductal gray matter and posterior deep white matter tracts, were also common, and although[ajnr.org] People with CJD will have ataxia, or difficulty controlling body movements, abnormal gait, speech, and dementia. It is always fatal, and there is no cure.[medicalnewstoday.com] A 69-year-old woman presented with an 11-month history of progressive dementia, irritability, insomnia, and gait disturbance without a family history of dementia or prion[ncbi.nlm.nih.gov]

  • Subacute Sclerosing Panencephalitis

    Later, high signal changes in deep white matter and severe cerebral atrophy were observed.[doi.org] Soon after, she developed difficulty walking and often talked to a “friend” who was not present.[pediatrics.aappublications.org] The initial symptoms of SSPE are subtle and include mild mental deterioration (such as memory loss) and changes in behavior (such as irritability) followed by disturbances[ninds.nih.gov]

  • Neonatal Adrenoleukodystrophy

    Individuals with CARASIL may develop a variety of symptoms relating to white matter involvement or leukoaraiosis (changes in deep white matter in the brain, which are observed[rarediseases.org] Other symptoms may include vision loss, learning disabilities, seizures, poorly articulated speech, difficulty swallowing, deafness, difficulty walking, poor coordination,[lorisnatural.com] […] include muscle weakness and fatigue, weight loss and decreased appetite, darkening of the skin, low blood pressure, fainting, cravings for salt, low blood sugar levels, irritability[lorisnatural.com]

  • Pineal Gland Cyst

    Today I received my results stating I have a few like foci of increased T2 signal in the deep periventricular white matter regions.[healthcaremagic.com] I have high blood pressure, postural orthostatic tackacardia, polycystic ovarian syndrome, diabeties, irritable bowel syndrome, acid reflux, and yesterday my thyroid shut[steadyhealth.com] People thought they were because of irritation from riding in bumpy Jeeps. For a while, the condition was called "Jeep disease."[webmd.com]

  • Stroke

    Early features include: loss of grey-white matter differentiation, and hypoattenuation of deep nuclei: lentiform nucleus changes seen as early as 1 hour after occlusion, visible[radiopaedia.org] Asymmetric step length is a common abnormal gait pattern in hemiplegic stroke patients.[ncbi.nlm.nih.gov] The leaked blood can irritate, damage or destroy surrounding brain cells.[uhnj.org]

  • Primary Progressive Multiple Sclerosis

    Consistent with this reduction, we showed that changes in diffusion indices of tissue damage within major clinically relevant white matter (corpus callosum and corticospinal[ncbi.nlm.nih.gov] A key symptom associated with PPMS is difficulty walking. This may result from the damage to the spinal cord that occurs with PPMS.[medicalnewstoday.com] Symptoms of the latter may include itchy skin, rash, hives, skin redness, flushing, low blood pressure, fever, fatigue, dizziness, headache, throat irritation, and shortness[clinicaladvisor.com]

  • Dementia

    It may be particularly related to frontal deep white matter lesions. 16 Cognitive and behavioral changes in SVD are due to disruption of the frontal cortico-subcortical circuit[doi.org] walking experiencing behaviour changes that may escalate and include aggression.[web.archive.org] We present the case of a 34-year-old Jordanian woman who was referred to mainstream mental health services because of irritability, agitation, loss of appetite, withdrawal[ncbi.nlm.nih.gov]

  • Multi-Infarct Dementia

    Several pathogenic mechanisms appear implicated in the causation the deep white matter changes of Binswanger's disease, and hypoxia-ischemia resulting from watershed injury[web.archive.org] Common neurological signs (e.g., abnormal reflexes, weakness of an extremity, gait disturbance) are discussed in the “Diagnostic Features” section.[courses.lumenlearning.com] Forgetfulness (but not as severe as Alzheimer's disease) Urinary incontinence Difficulty walking Clumsiness Changes in personality or mood (most likely in the form of apathy, irritability[alzheimers.emedtv.com]

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