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110 Possible Causes for Abnormal Gait, Deep White Matter Changes, Paresthesia

  • Stroke

    Early features include: loss of grey-white matter differentiation, and hypoattenuation of deep nuclei: lentiform nucleus changes seen as early as 1 hour after occlusion, visible[radiopaedia.org] Asymmetric step length is a common abnormal gait pattern in hemiplegic stroke patients.[ncbi.nlm.nih.gov] Doctors may refer to the tingling sensations as paresthesia. Here we look at possible causes, diagnosis, and treatment options.[medicalnewstoday.com]

  • Primary Progressive Multiple Sclerosis

    Consistent with this reduction, we showed that changes in diffusion indices of tissue damage within major clinically relevant white matter (corpus callosum and corticospinal[ncbi.nlm.nih.gov] A key symptom associated with PPMS is difficulty walking. This may result from the damage to the spinal cord that occurs with PPMS.[medicalnewstoday.com] Symptoms in-clude pain, weakness, numbness, tingling, paralysis, tremors, and muscle dysfunction.[medical-dictionary.thefreedictionary.com]

  • Adult Polyglucosan Body Disease

    MRI of the brain and spinal cord reveals the following: Paraventricular, subcortical, and deep white matter changes that may include involvement of the upper pons, superior[ncbi.nlm.nih.gov] Progressive spasticity and weakness are also present due to upper and lower motor neuron involvement and patients have difficulty walking.[orpha.net] […] matter abnormalities (MRI) polyglucosan bodies (round intracellular inclusions) found in neuronal and astrocytic processes peripheral neuropathy distal sensory impairment paresthesias[humpath.com]

  • Pineal Gland Cyst

    Today I received my results stating I have a few like foci of increased T2 signal in the deep periventricular white matter regions.[healthcaremagic.com] […] old iv had strange symptoms since a bang to the head such as migraines, dizzy, nausea, hallucinations at night and waking up screaming, depression/anxiety, blurred vision, tingling[medhelp.org] Strange headaches, tingling and pressure in my head I had a strange headaches that were not like regular headaches.[pinealglandcystsurgery.com]

  • Binswanger Disease

    OBJECTIVES: To analyse the diagnostic and prognostic value of periventricular hyperintensity (PVH) and deep white matter hyperintensity (DWMH) magnetic resonance imaging ([ncbi.nlm.nih.gov] The abnormality of gait that may occur in patients with subcortical arteriosclerotic encephalopathy is described in 12 patients in whom difficulty walking was the presenting[medigoo.com] Opsoclonus Myoclonus Orthostatic Hypotension O’Sullivan-McLeod Syndrome Overuse Syndrome Pain – Chronic Pantothenate Kinase-Associated Neurodegeneration Paraneoplastic Syndromes Paresthesia[gncdubai.com]

  • CADASIL Syndrome

    MR imaging lesion load correlated with some clinical features including stroke and dementia, whereas depression is more common in individuals with deep white matter changes[ajnr.org] This can result in an unsteady and wide based gait or sometimes an abnormal gait due to small steps. Should antiplatelet agents such as Aspirin be prescribed in CADASIL?[cambridgestroke.com] At the neurological examination, she presented psychomotor slowness, confusion, difficulty in speech, left lateral hemianopia, and paresthesias on the left side of the face[link.springer.com]

  • Machado-Joseph Disease

    Magnetic resonance spectroscopy (MRS) of the deep white matter has demonstrated changes indicative of axonal dysfunction, although MRI in the same study did not reveal any[symptoma.com] walking due to muscle spasms (spastic gait) Poor reflexes Type III (MJD-III) Between 40-70 years of age Symptoms slowly worsen over time Muscle twitching Numbness, tingling[rarediseases.about.com] Early symptoms and signs of neuropathy are paresthesia and hyperesthesia of the extremities, with disappearance of deep tendon reflexes.[karger.com]

  • Progressive Multifocal Leukoencephalopathy

    This suggests that increasing severity of cortical and deep atrophy, increasing confluence and extent of white matter lesions, spread of disease across the corpus callosum[ajnr.org] Limb weakness, gait abnormalities, visual loss, and altered mental status were the commonest initial complaints.[annals.org] The patient experienced additional paresthesia on the left side of her face and swallowing difficulties.[karger.com]

  • Metachromatic Leukodystrophy

    Markers serum/urine arylsulfatase A levels: reduced MRI Characterized by bilateral symmetrical confluent areas of periventricular deep white matter signal change, in particular[radiopaedia.org] Diagnosis is based on the onset of neurological symptoms, presence of gait abnormalities, spasticity, decreased muscle stretch reflexes and neuro-radiological evidence of[ncbi.nlm.nih.gov] Common findings associated with peripheral neuropathy may include muscle weakness; pain; numbness; redness; and/or burning or tingling sensations in the affected areas, especially[thinkgenetic.com]

  • Huntington's Disease

    Both deep grey matter and to a lesser degree white matter are involved in HD.[radiopaedia.org] Gait abnormalities: Gait abnormalities start developing in the intermediate stage of the disease. The gait is irregular and unsteady.[symptoma.com] There have been reports of patients who suffered permanent losses of cervical spinal cord function during this practice; however, these cases employed long needles and paresthesia[ncbi.nlm.nih.gov]

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