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105 Possible Causes for Abnormal Gait, Deep White Matter Changes, Poor Coordination

  • Stroke

    Early features include: loss of grey-white matter differentiation, and hypoattenuation of deep nuclei: lentiform nucleus changes seen as early as 1 hour after occlusion, visible[radiopaedia.org] Asymmetric step length is a common abnormal gait pattern in hemiplegic stroke patients.[ncbi.nlm.nih.gov] […] involves being cleared by the doctor (who will be aware of relevant government regulations) as the stroke may have left subtle impairments, not always apparent, such as poor[brainfoundation.org.au]

  • Primary Progressive Multiple Sclerosis

    Consistent with this reduction, we showed that changes in diffusion indices of tissue damage within major clinically relevant white matter (corpus callosum and corticospinal[ncbi.nlm.nih.gov] A key symptom associated with PPMS is difficulty walking. This may result from the damage to the spinal cord that occurs with PPMS.[medicalnewstoday.com] People with PPMS may have trouble with balance and coordination or have difficulty walking.[healthline.com]

  • Huntington's Disease

    Both deep grey matter and to a lesser degree white matter are involved in HD.[radiopaedia.org] Gait abnormalities: Gait abnormalities start developing in the intermediate stage of the disease. The gait is irregular and unsteady.[symptoma.com] Early signs and symptoms can include irritability, depression, small involuntary movements, poor coordination, and trouble learning new information or making decisions.[ghr.nlm.nih.gov]

  • Ataxia Telangiectasia

    Occasionally, lesions that are consistent with small vessel ischemic or degenerative changes have been noted in the deep white matter of the cerebral hemispheres.[appliedradiology.com] The records of all patients seen at the Ataxia-Telangiectasia Clinical Center from July 1, 1995 to April 1, 1997 were reviewed to determine age of onset of gait abnormality[ncbi.nlm.nih.gov] Ataxia refers to poor coordination and telangiectasia to small dilated blood vessels, both of which are hallmarks of the disease.[dbpedia.org]

  • Neonatal Adrenoleukodystrophy

    Individuals with CARASIL may develop a variety of symptoms relating to white matter involvement or leukoaraiosis (changes in deep white matter in the brain, which are observed[rarediseases.org] Other symptoms may include vision loss, learning disabilities, seizures, poorly articulated speech, difficulty swallowing, deafness, difficulty walking, poor coordination,[thesourcenatural.com] […] disabilities, seizures, difficulty swallowing, deafness, difficulty walking, poor coordination, and fatigue.[thesourcenatural.com]

  • Pineal Gland Cyst

    Today I received my results stating I have a few like foci of increased T2 signal in the deep periventricular white matter regions.[healthcaremagic.com] Other symptoms include memory problems, poor coordination and tremors.[neurosurgerydallas.com] These are compatible with ischemic/gliotic changes, or could represent the sequela of migraine headaches. It also states I have a small simple pineal cyst ...[healthcaremagic.com]

  • Binswanger Disease

    OBJECTIVES: To analyse the diagnostic and prognostic value of periventricular hyperintensity (PVH) and deep white matter hyperintensity (DWMH) magnetic resonance imaging ([ncbi.nlm.nih.gov] The abnormality of gait that may occur in patients with subcortical arteriosclerotic encephalopathy is described in 12 patients in whom difficulty walking was the presenting[medigoo.com] Affected individuals may also develop poor coordination and slurred speech.[alzheimersweekly.com]

  • Dementia

    It may be particularly related to frontal deep white matter lesions. 16 Cognitive and behavioral changes in SVD are due to disruption of the frontal cortico-subcortical circuit[doi.org] walking experiencing behaviour changes that may escalate and include aggression.[web.archive.org] Symptoms may include difficulties walking, clumsiness, lack of facial expression and speech difficulties. Loss of bladder control early on in the disease is also common.[web.archive.org]

  • Multi-Infarct Dementia

    Several pathogenic mechanisms appear implicated in the causation the deep white matter changes of Binswanger's disease, and hypoxia-ischemia resulting from watershed injury[web.archive.org] Common neurological signs (e.g., abnormal reflexes, weakness of an extremity, gait disturbance) are discussed in the “Diagnostic Features” section.[courses.lumenlearning.com] Periventricular and deep white matter changes on T 2 -weighted MRI that are excessive for age 2 … … 3. Focal changes in electroencephalographic studies 3 27 1 31.8 D.[doi.org]

  • Hereditary Cerebellar Degeneration

    Axial T2 image shows signal change affecting the deep cerebellar white matter ( arrow s).[ajnr.org] Clinical signs are varied, with some patients having limb and gait ataxia along with episodic headaches or nausea, and others having gait ataxia, speech difficulty, and abnormal[encyclopedia.com] Initial ataxia symptoms usually include: Poor limb coordination. Dysarthria - slurred and slow speech that is difficult to produce.[medicalnewstoday.com]

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