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82 Possible Causes for Abnormal Gait, Deep White Matter Changes, Psychiatric Manifestation

  • Primary Progressive Multiple Sclerosis

    Consistent with this reduction, we showed that changes in diffusion indices of tissue damage within major clinically relevant white matter (corpus callosum and corticospinal[ncbi.nlm.nih.gov] A key symptom associated with PPMS is difficulty walking. This may result from the damage to the spinal cord that occurs with PPMS.[medicalnewstoday.com] People with PPMS may have trouble with balance and coordination or have difficulty walking.[healthline.com]

  • Huntington's Disease

    Huntington's disease (HD) is an autosomal dominant and progressive neurodegenerative syndrome characterized by motor, cognitive and psychiatric manifestations.[ncbi.nlm.nih.gov] Both deep grey matter and to a lesser degree white matter are involved in HD.[radiopaedia.org] Gait abnormalities: Gait abnormalities start developing in the intermediate stage of the disease. The gait is irregular and unsteady.[symptoma.com]

  • Subacute Sclerosing Panencephalitis

    Psychiatric manifestation of SSPE. J Neuropsychiatry Clin Neurosci 2006;18:560. [ PUBMED ] 3. Kartal A, Kurt AN, Gürkas E, Aydin K, Serdaroglu A.[ijpm.info] Later, high signal changes in deep white matter and severe cerebral atrophy were observed.[doi.org] Soon after, she developed difficulty walking and often talked to a “friend” who was not present.[pediatrics.aappublications.org]

  • Binswanger Disease

    manifestations, geriatric and dementing conditions, and drug and alcohol abuse * A look at the narrow margin between mental and organic dysfunctions * The interaction of[books.google.de] OBJECTIVES: To analyse the diagnostic and prognostic value of periventricular hyperintensity (PVH) and deep white matter hyperintensity (DWMH) magnetic resonance imaging ([ncbi.nlm.nih.gov] The abnormality of gait that may occur in patients with subcortical arteriosclerotic encephalopathy is described in 12 patients in whom difficulty walking was the presenting[medigoo.com]

  • Hyponatremia

    However, endocrinologic manifestations from Hg exposure are less well known.[ncbi.nlm.nih.gov] In the brain MRI, millimeter-sized chronic microangiopathic ischemic signal changes were observed in the periventricular deep white matter; no mass image was seen in the pituitary[reumatologiaclinica.org] walking.[casesjournal.biomedcentral.com]

  • Stroke

    While spasms of this muscle constitute the hallmark of disease, other motor manifestations include increased spontaneous blinking and apraxia of eyelid opening.[ncbi.nlm.nih.gov] Early features include: loss of grey-white matter differentiation, and hypoattenuation of deep nuclei: lentiform nucleus changes seen as early as 1 hour after occlusion, visible[radiopaedia.org] Asymmetric step length is a common abnormal gait pattern in hemiplegic stroke patients.[ncbi.nlm.nih.gov]

  • Dementia

    The first step to better understand the psychiatric manifestations of dementia is to appropriately recognize and describe the psychopathology and accurately distinguish between[doi.org] It may be particularly related to frontal deep white matter lesions. 16 Cognitive and behavioral changes in SVD are due to disruption of the frontal cortico-subcortical circuit[doi.org] walking experiencing behaviour changes that may escalate and include aggression.[web.archive.org]

  • Psychosis

    According to the literature, this psychiatric manifestation resolves within 2 weeks of discontinuing the offending agent.[ncbi.nlm.nih.gov] matter changes – Surface changes of deep brain nuclei – Functional changes covary with symptomatology *In all but the first area, results are in comparison to control groups[ncbi.nlm.nih.gov] abnormality, clonus, or spasticity) confusion, cognitive deficit, history of malignancy head trauma immunocompromised state atypical psychotic symptoms (such as visual or[mdedge.com]

  • CADASIL Syndrome

    Other manifestations include psychiatric disorders, confusion, epilepsy, seizures, migraine headaches, dementia and other cognitive impairments.[brighthub.com] MR imaging lesion load correlated with some clinical features including stroke and dementia, whereas depression is more common in individuals with deep white matter changes[ajnr.org] This can result in an unsteady and wide based gait or sometimes an abnormal gait due to small steps. Should antiplatelet agents such as Aspirin be prescribed in CADASIL?[cambridgestroke.com]

  • Bipolar Disorder

    Psychiatric manifestations of Cushing’s syndrome: response to lowering of plasma cortisol. Q J Med 1979; 191: 465–72 Google Scholar 26.[doi.org] white matter abnormalities in individuals with BD ( Vederine et al. 2011 ; Torgerson et al. 2012).[ncbi.nlm.nih.gov] Muller* 1999 and Tohen 2000 used this scale which assesses extra‐pyramidal symptoms (signs relating to the abnormality of gait, muscle rigidity and resistance to movement,[doi.org]

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