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99 Possible Causes for Abnormal Gait, Deep White Matter Changes, Slow Speech

  • Stroke

    Early features include: loss of grey-white matter differentiation, and hypoattenuation of deep nuclei: lentiform nucleus changes seen as early as 1 hour after occlusion, visible[radiopaedia.org] […] language problems Slow, cautious behavior Memory loss Rehabilitation following a stroke may involve a number of medical specialists; but the early diagnosis of a stroke,[aans.org] Asymmetric step length is a common abnormal gait pattern in hemiplegic stroke patients.[ncbi.nlm.nih.gov]

  • Binswanger Disease

    OBJECTIVES: To analyse the diagnostic and prognostic value of periventricular hyperintensity (PVH) and deep white matter hyperintensity (DWMH) magnetic resonance imaging ([ncbi.nlm.nih.gov] Other prominent features of the disease include urinary incontinence, difficulty walking, clumsiness, slowness of conduct, lack of facial expression, and speech difficulty[prep4usmle.com] The abnormality of gait that may occur in patients with subcortical arteriosclerotic encephalopathy is described in 12 patients in whom difficulty walking was the presenting[medigoo.com]

  • Primary Progressive Multiple Sclerosis

    Consistent with this reduction, we showed that changes in diffusion indices of tissue damage within major clinically relevant white matter (corpus callosum and corticospinal[ncbi.nlm.nih.gov] A key symptom associated with PPMS is difficulty walking. This may result from the damage to the spinal cord that occurs with PPMS.[medicalnewstoday.com] People with PPMS may have trouble with balance and coordination or have difficulty walking.[healthline.com]

  • Hallervorden-Spatz Syndrome

    Brain stem nuclei had similar changes. The high signal intensity lesions in the deep cerebral white matter and dentate nuclei were unchanged.[ajnr.org] These abnormalities progressed over the years with slowing of voluntary movements, rigidity of limbs and dystonic posturing. Speech was slurred.[jpgmonline.com] The early onset childhood group had uniform presentation with developmental delay, recurrent falls, gait abnormalities, cognitive deterioration and dystonia.[ncbi.nlm.nih.gov]

  • Huntington's Disease

    Both deep grey matter and to a lesser degree white matter are involved in HD.[radiopaedia.org] speech or difficulty swallowing Slowed thinking and reaction time, difficulty planning and organizing, inflexible thinking, poor decision making skills or problems with short-term[health.ucsd.edu] Gait abnormalities: Gait abnormalities start developing in the intermediate stage of the disease. The gait is irregular and unsteady.[symptoma.com]

  • Ataxia Telangiectasia

    Occasionally, lesions that are consistent with small vessel ischemic or degenerative changes have been noted in the deep white matter of the cerebral hemispheres.[appliedradiology.com] Due to lack of muscle control children lose their ability to write and speech becomes slowed and slurred. Even eye movements become difficult to control.[pediatriconcall.com] The records of all patients seen at the Ataxia-Telangiectasia Clinical Center from July 1, 1995 to April 1, 1997 were reviewed to determine age of onset of gait abnormality[ncbi.nlm.nih.gov]

  • Creutzfeldt Jakob Disease

    Some other features, such as the presence of abnormal hyperintensity in the periaqueductal gray matter and posterior deep white matter tracts, were also common, and although[ajnr.org] A 59-year-old woman presented with a 2-month history of headache, difficulty in finding words, and slow speech.[doi.org] People with CJD will have ataxia, or difficulty controlling body movements, abnormal gait, speech, and dementia. It is always fatal, and there is no cure.[medicalnewstoday.com]

  • Hereditary Cerebellar Degeneration

    Axial T2 image shows signal change affecting the deep cerebellar white matter ( arrow s).[ajnr.org] Dysarthria - slurred and slow speech that is difficult to produce. The patient may also have difficulties controlling volume, rhythm, and pitch.[medicalnewstoday.com] Clinical signs are varied, with some patients having limb and gait ataxia along with episodic headaches or nausea, and others having gait ataxia, speech difficulty, and abnormal[encyclopedia.com]

  • Adult Polyglucosan Body Disease

    MRI of the brain and spinal cord reveals the following: Paraventricular, subcortical, and deep white matter changes that may include involvement of the upper pons, superior[ncbi.nlm.nih.gov] […] disturbance consisting of slow, low volume speech.[jnnp.bmj.com] Progressive spasticity and weakness are also present due to upper and lower motor neuron involvement and patients have difficulty walking.[orpha.net]

  • CADASIL Syndrome

    MR imaging lesion load correlated with some clinical features including stroke and dementia, whereas depression is more common in individuals with deep white matter changes[ajnr.org] At the neurological examination, she presented psychomotor slowness, confusion, difficulty in speech, left lateral hemianopia, and paresthesias on the left side of the face[link.springer.com] This can result in an unsteady and wide based gait or sometimes an abnormal gait due to small steps. Should antiplatelet agents such as Aspirin be prescribed in CADASIL?[cambridgestroke.com]

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