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92 Possible Causes for Abnormal Gait, Deep White Matter Changes, Spastic Gait

  • Stroke

    Early features include: loss of grey-white matter differentiation, and hypoattenuation of deep nuclei: lentiform nucleus changes seen as early as 1 hour after occlusion, visible[radiopaedia.org] Asymmetric step length is a common abnormal gait pattern in hemiplegic stroke patients.[ncbi.nlm.nih.gov] ., face drooping, hemiparesis/hemiplegia, inability to lift ipsilateral arm or abnormal gait Contralateral sensory loss Contralateral homonymous hemianopia Dysphasia Dysphagia[symptoma.com]

  • Primary Progressive Multiple Sclerosis

    Consistent with this reduction, we showed that changes in diffusion indices of tissue damage within major clinically relevant white matter (corpus callosum and corticospinal[ncbi.nlm.nih.gov] A key symptom associated with PPMS is difficulty walking. This may result from the damage to the spinal cord that occurs with PPMS.[medicalnewstoday.com] A 28-year-old woman developed progressive spastic gait and dysarthria.[ncbi.nlm.nih.gov]

  • Huntington's Disease

    Both deep grey matter and to a lesser degree white matter are involved in HD.[radiopaedia.org] Gait abnormalities: Gait abnormalities start developing in the intermediate stage of the disease. The gait is irregular and unsteady.[symptoma.com] At age 48, rigidity and spastic gait were observed. One year later, choreoathetoid involuntary movements became apparent.[ncbi.nlm.nih.gov]

  • Infantile Neuroaxonal Dystrophy

    In one patient (juvenile case) with lesions in the deep frontal white matter, an elevated diffusion pattern was evident.[ajnr.org] Clinical Onset before age 20 years Psychomotor regression Gait abnormalities Prominent expressive language difficulties Psychiatric/behavioral abnormalities including autistic-like[ncbi.nlm.nih.gov] Gait disturbance, limb spasticity, cerebellar signs, and optic atrophy are other common features associated with INAD.[ncbi.nlm.nih.gov]

  • Adult Polyglucosan Body Disease

    MRI of the brain and spinal cord reveals the following: Paraventricular, subcortical, and deep white matter changes that may include involvement of the upper pons, superior[ncbi.nlm.nih.gov] Progressive spasticity and weakness are also present due to upper and lower motor neuron involvement and patients have difficulty walking.[orpha.net] Adult polyglucosan body disease (APBD) is an autosomal recessive leukodystrophy characterized by neurogenic bladder, progressive spastic gait, and peripheral neuropathy.[ncbi.nlm.nih.gov]

  • Machado-Joseph Disease

    Magnetic resonance spectroscopy (MRS) of the deep white matter has demonstrated changes indicative of axonal dysfunction, although MRI in the same study did not reveal any[symptoma.com] walking due to muscle spasms (spastic gait) Poor reflexes Type III (MJD-III) Between 40-70 years of age Symptoms slowly worsen over time Muscle twitching Numbness, tingling[rarediseases.about.com] The majority of patients develop gait abnormalities and a series of other neurological symptoms between the ages of 20 and 40.[news-medical.net]

  • Binswanger Disease

    OBJECTIVES: To analyse the diagnostic and prognostic value of periventricular hyperintensity (PVH) and deep white matter hyperintensity (DWMH) magnetic resonance imaging ([ncbi.nlm.nih.gov] The abnormality of gait that may occur in patients with subcortical arteriosclerotic encephalopathy is described in 12 patients in whom difficulty walking was the presenting[medigoo.com] […] disturbance Hyperreflexia Low back pain Progressive encephalopathy Pseudobulbar signs Rigidity Spasticity Urinary incontinence Last updated: 1/1/2017 Source: GARD (NIH) 1[familydiagnosis.com]

  • Autosomal Dominant Spastic Paraplegia Type 8

    Enlarged ventricles, a thin corpus callosum, and periventricular white matter changes may also be present.[disorders.eyes.arizona.edu] The father, brother, and uncle were both asymptomatic while the grandfather was wheelchairbound and the mother had abnormal gait.[omicsonline.org] SPG4 is characterized by insidiously progressive bilateral lower-limb gait spasticity.[centogene.com]

  • Hallervorden-Spatz Syndrome

    Brain stem nuclei had similar changes. The high signal intensity lesions in the deep cerebral white matter and dentate nuclei were unchanged.[ajnr.org] The early onset childhood group had uniform presentation with developmental delay, recurrent falls, gait abnormalities, cognitive deterioration and dystonia.[ncbi.nlm.nih.gov] Each patient had spastic gait, dysarthria, dystonic posturing of both arms and generalized hyperreflexia, but no Kayser-Fleischer rings or retinitis pigmentosa.[ncbi.nlm.nih.gov]

  • Metachromatic Leukodystrophy

    Markers serum/urine arylsulfatase A levels: reduced MRI Characterized by bilateral symmetrical confluent areas of periventricular deep white matter signal change, in particular[radiopaedia.org] Diagnosis is based on the onset of neurological symptoms, presence of gait abnormalities, spasticity, decreased muscle stretch reflexes and neuro-radiological evidence of[ncbi.nlm.nih.gov] A 25-month-old female child presented with a cranial neuropathy, a spastic gait, decreased leukocyte arylsulfatase-A activity, and elevated urinary sulfatides.[ncbi.nlm.nih.gov]

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