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75 Possible Causes for Abnormal Gait, Deep White Matter Changes, Spastic Paralysis

  • Stroke

    Cerebral hemisphere infarcts may cause: Contralateral hemiplegia which is initially flaccid (floppy limb, falls like a dead weight when lifted) and then becomes spastic.[patient.info] Early features include: loss of grey-white matter differentiation, and hypoattenuation of deep nuclei: lentiform nucleus changes seen as early as 1 hour after occlusion, visible[radiopaedia.org] Asymmetric step length is a common abnormal gait pattern in hemiplegic stroke patients.[ncbi.nlm.nih.gov]

  • Primary Progressive Multiple Sclerosis

    Affected individuals may have tremors, muscle stiffness (spasticity), exaggerated reflexes (hyperreflexia), weakness or partial paralysis of the muscles of the limbs, difficulty[icdlist.com] Consistent with this reduction, we showed that changes in diffusion indices of tissue damage within major clinically relevant white matter (corpus callosum and corticospinal[ncbi.nlm.nih.gov] A key symptom associated with PPMS is difficulty walking. This may result from the damage to the spinal cord that occurs with PPMS.[medicalnewstoday.com]

  • Diffuse Cerebral Sclerosis of Schilder

    change in the deep white matter.[doi.org] The most common symptoms are usually behavioral changes such as abnormal withdrawal or aggression, poor memory, and poor school performance.[ninds.nih.gov] […] disorders, leg stiffness or weakness, abnormalities of sphincter control, and sexual dysfunction, with or without adrenal insufficiency or cognitive or behavioral deficits[ncbi.nlm.nih.gov]

  • Creutzfeldt Jakob Disease

    Some other features, such as the presence of abnormal hyperintensity in the periaqueductal gray matter and posterior deep white matter tracts, were also common, and although[ajnr.org] People with CJD will have ataxia, or difficulty controlling body movements, abnormal gait, speech, and dementia. It is always fatal, and there is no cure.[medicalnewstoday.com] Symptoms may include behavior changes, confusion, memory problems, stiff muscles, loss of feeling in arms, legs or face, loss of balance, difficulty walking, muscle spasms[nj.gov]

  • Binswanger Disease

    Paralysis Farber’s Disease Febrile Seizures Fibromuscular Dysplasia Fisher Syndrome Floppy Infant Syndrome Foot Drop Friedreich’s Ataxia Frontotemporal Dementia Gaucher Disease[gncdubai.com] OBJECTIVES: To analyse the diagnostic and prognostic value of periventricular hyperintensity (PVH) and deep white matter hyperintensity (DWMH) magnetic resonance imaging ([ncbi.nlm.nih.gov] The abnormality of gait that may occur in patients with subcortical arteriosclerotic encephalopathy is described in 12 patients in whom difficulty walking was the presenting[medigoo.com]

  • Pineal Gland Cyst

    […] of the extra-ocular muscles; 3) papilledema, weakness, and spasticity. 2 Two common syndromes associated with pineal region masses include the Sylvian aqueduct syndrome and[jaocr.org] Today I received my results stating I have a few like foci of increased T2 signal in the deep periventricular white matter regions.[healthcaremagic.com] […] pineal region masses: 1) headaches with nausea and vomiting; 2) blurred vision, diplopia, changes in mental states, drowsiness, papillary changes, ataxia or dizziness, and paralysis[jaocr.org]

  • Lafora Disease

    […] ataxia Charlevoix-Saguenay type Detection of mutations c.6594delT and c.5254C T in the SACS gene Spastic paralysis, infantile onset ascending NGS and Sanger Sequencing of[pentacorelab.hu] matter signal, Deep frontoparietal cerebral changes at 10 years of age Child onset: Weakness Clinical Weakness: Proximal; Symmetric Muscle size: Calf hypertrophy Subgroup[neuromuscular.wustl.edu] Lafora disease causes seizures, muscle spasms, difficulty walking, dementia, and eventually death.[diseaseinfosearch.org]

  • Sjögren-Larsson Syndrome

    paralysis.[medical-dictionary.thefreedictionary.com] MRI demonstrated the white matter changes deep in the cerebral hemispheres. We analyse the MRI findings and compare the results with neuropsychological signs.[ncbi.nlm.nih.gov] It results in: Abnormal gait Paresis (weak muscles) Spasticity (muscle stiffness and spasms). Children may have speech delay and intellectual impairment.[dermnetnz.org]

  • Hereditary Cerebellar Degeneration

    Spastic quadraparesis 2. Marked cerebellar ataxia 3. Spastic and ataxic dysarthria 4. Global supranuclear paralysis of vertical gaze 5.[collections.lib.utah.edu] Axial T2 image shows signal change affecting the deep cerebellar white matter ( arrow s).[ajnr.org] Clinical signs are varied, with some patients having limb and gait ataxia along with episodic headaches or nausea, and others having gait ataxia, speech difficulty, and abnormal[encyclopedia.com]

  • Metachromatic Leukodystrophy

    Seizures usually occur, followed by paralysis and dementia. Children may become comatose.[secure.ssa.gov] Markers serum/urine arylsulfatase A levels: reduced MRI Characterized by bilateral symmetrical confluent areas of periventricular deep white matter signal change, in particular[radiopaedia.org] Diagnosis is based on the onset of neurological symptoms, presence of gait abnormalities, spasticity, decreased muscle stretch reflexes and neuro-radiological evidence of[ncbi.nlm.nih.gov]

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