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154 Possible Causes for Abnormal Gait, Deep White Matter Changes, Tremor

  • Pineal Gland Cyst

    Today I received my results stating I have a few like foci of increased T2 signal in the deep periventricular white matter regions.[healthcaremagic.com] […] lethargy vertigo sleep problems coma In addition to the above, there are also some core anecdotal symptoms derived from forums with people with pineal gland cysts: fatigue tremors[hubpages.com] Yes, the "incidental pineal cyst", headache for 3 years straight, tremors, unbelievable pain (joint, muscle, spine, neck, knees, everywhere) that seems to move from place[steadyhealth.com]

  • Primary Progressive Multiple Sclerosis

    Consistent with this reduction, we showed that changes in diffusion indices of tissue damage within major clinically relevant white matter (corpus callosum and corticospinal[ncbi.nlm.nih.gov] Other symptoms that may be treated with drugs include seizures, vertigo, and tremor.[medical-dictionary.thefreedictionary.com] A key symptom associated with PPMS is difficulty walking. This may result from the damage to the spinal cord that occurs with PPMS.[medicalnewstoday.com]

  • Hereditary Cerebellar Degeneration

    Axial T2 image shows signal change affecting the deep cerebellar white matter ( arrow s).[ajnr.org] Tremor, if present, is slight. Reflexes and vibration and position senses are lost. Talipes equinovarus (clubfoot), scoliosis, and progressive cardiomyopathy are common.[msdmanuals.com] Clinical signs are varied, with some patients having limb and gait ataxia along with episodic headaches or nausea, and others having gait ataxia, speech difficulty, and abnormal[encyclopedia.com]

  • Huntington's Disease

    Both deep grey matter and to a lesser degree white matter are involved in HD.[radiopaedia.org] Thus there is a biotype in which the tremors are absent, but mental deterioration present; a biotype in which the tremors are not accompanied by mental deterioration; a biotype[doi.org] Gait abnormalities: Gait abnormalities start developing in the intermediate stage of the disease. The gait is irregular and unsteady.[symptoma.com]

  • Hallervorden-Spatz Syndrome

    Brain stem nuclei had similar changes. The high signal intensity lesions in the deep cerebral white matter and dentate nuclei were unchanged.[ajnr.org] […] arm and resting tremor in upper extremities.[ncbi.nlm.nih.gov] The early onset childhood group had uniform presentation with developmental delay, recurrent falls, gait abnormalities, cognitive deterioration and dystonia.[ncbi.nlm.nih.gov]

  • Cerebellar Ataxia

    Axial T2 image shows signal change affecting the deep cerebellar white matter ( arrow s).[ajnr.org] Postural tremor in patient 1.[ncbi.nlm.nih.gov] The study reports that among the remaining 29 patients, 25 required no gait aid, but had an abnormal gait, and four patients had normal gait. ### About Mayo Clinic Mayo Clinic[eurekalert.org]

  • Binswanger Disease

    OBJECTIVES: To analyse the diagnostic and prognostic value of periventricular hyperintensity (PVH) and deep white matter hyperintensity (DWMH) magnetic resonance imaging ([ncbi.nlm.nih.gov] Other prominent features of the disease include urinary incontinence, difficulty walking, parkinsonian-like tremors, and depression.[ucl.ac.uk] The abnormality of gait that may occur in patients with subcortical arteriosclerotic encephalopathy is described in 12 patients in whom difficulty walking was the presenting[medigoo.com]

  • Adult Polyglucosan Body Disease

    MRI of the brain and spinal cord reveals the following: Paraventricular, subcortical, and deep white matter changes that may include involvement of the upper pons, superior[ncbi.nlm.nih.gov] REPORT OF A CASE A 46-year-old woman initially presented with a 4-year history of resting tremor. The tremor responded to levodopa therapy.[ncbi.nlm.nih.gov] Progressive spasticity and weakness are also present due to upper and lower motor neuron involvement and patients have difficulty walking.[orpha.net]

  • Machado-Joseph Disease

    Magnetic resonance spectroscopy (MRS) of the deep white matter has demonstrated changes indicative of axonal dysfunction, although MRI in the same study did not reveal any[symptoma.com] […] disease (MJD), the most frequent SCA subtype worldwide and other rare spinocerebellar ataxias including dentatorubral-pallidoluysian atrophy (DRPLA), the X-linked fragile X tremor[ncbi.nlm.nih.gov] walking due to muscle spasms (spastic gait) Poor reflexes Type III (MJD-III) Between 40-70 years of age Symptoms slowly worsen over time Muscle twitching Numbness, tingling[rarediseases.about.com]

  • Diffuse Cerebral Sclerosis of Schilder

    change in the deep white matter.[doi.org] Diagnosis Symptoms Symptoms are similar to those in multiple sclerosis and may include dementia, aphasia, seizures, personality changes, poor attention, tremors, instability[wikidoc.org] The most common symptoms are usually behavioral changes such as abnormal withdrawal or aggression, poor memory, and poor school performance.[ninds.nih.gov]

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