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170 Possible Causes for Abnormal Gait, Deep White Matter Changes, Weakness

  • Stroke

    Early features include: loss of grey-white matter differentiation, and hypoattenuation of deep nuclei: lentiform nucleus changes seen as early as 1 hour after occlusion, visible[radiopaedia.org] Asymmetric step length is a common abnormal gait pattern in hemiplegic stroke patients.[ncbi.nlm.nih.gov] weakness; there were two patients with stroke of undetermined etiology and they had uniform finger weakness.[ncbi.nlm.nih.gov]

  • Pineal Gland Cyst

    Today I received my results stating I have a few like foci of increased T2 signal in the deep periventricular white matter regions.[healthcaremagic.com] Customer: She said it could be just a weak muscle neuromd2012 : very good.[justanswer.com] I was having all kinds of weird neurological symptoms last fall...strong pressure in my head, dizziness, weakness, headaches, etc.[healthboards.com]

  • Primary Progressive Multiple Sclerosis

    Consistent with this reduction, we showed that changes in diffusion indices of tissue damage within major clinically relevant white matter (corpus callosum and corticospinal[ncbi.nlm.nih.gov] A key symptom associated with PPMS is difficulty walking. This may result from the damage to the spinal cord that occurs with PPMS.[medicalnewstoday.com] Facial numbness and weakness are also common.[medical-dictionary.thefreedictionary.com]

  • Congenital Muscular Dystrophy

    Apparent diffusion coefficient (ADC) map may reveal increased signal intensity and apparent diffusion coefficient values in the periventricular and deep white matters.[ncbi.nlm.nih.gov] Persons affected with RSMD1 experience difficulty walking due to thigh muscle weakness, spinal rigidity, and mild Achilles tendon tightness.[disabled-world.com] KEYWORDS: Collagen; Fibrosis; IGF-1; Mesenchymal; Mouse; Muscular dystrophy; Skeletal muscles; Weakness[ncbi.nlm.nih.gov]

  • Glycogen Storage Disease Type 2

    matter signal, Deep frontoparietal cerebral changes at 10 years of age Child onset: Weakness Clinical Weakness: Proximal; Symmetric Muscle size: Calf hypertrophy Subgroup[neuromuscular.wustl.edu] abnormalities Muscle pain Difficulty climbing stairs Frequent falls Scapular winging Respiratory Frequent infections Respiratory insufficiency Cardio-respiratory failure[cuh.nhs.uk] The muscles in the arms and legs look typical, but are very weak. Breathing muscles are also weak.[web.archive.org]

  • Subacute Sclerosing Panencephalitis

    Later, high signal changes in deep white matter and severe cerebral atrophy were observed.[doi.org] Soon after, she developed difficulty walking and often talked to a “friend” who was not present.[pediatrics.aappublications.org] […] system disease: Slow viruses Subacute sclerosing panencephalitis is characterized by the slowly increasing loss of mental abilities, brief, shocklike jerking of the body, weakness[britannica.com]

  • Adult Polyglucosan Body Disease

    MRI of the brain and spinal cord reveals the following: Paraventricular, subcortical, and deep white matter changes that may include involvement of the upper pons, superior[ncbi.nlm.nih.gov] Progressive spasticity and weakness are also present due to upper and lower motor neuron involvement and patients have difficulty walking.[orpha.net] The inability to breakdown glycogen in muscle cells causes muscle weakness. The probable end result is cirrhosis and death within 5 years.[en.wikipedia.org]

  • Autosomal Dominant Progressive External Ophthalmoplegia Type 6

    Magnetic resonance imaging of the brain revealed volume loss and periventricular and deep white matter signal change; however, these features were generalized rather than[jamanetwork.com] Progressive external ophthalmoplegia Obstructive sleep apnea Exertional dyspnea Generalized amyotrophy Sleep apnea Difficulty walking Apnea Dyspnea Tremor Elevated serum[mendelian.co] The severity and pattern of muscle weakness varies, but most affected individuals show mildly delayed motor development, hypotonia, generalized muscle weakness, and weakness[mendelian.co]

  • Neonatal Adrenoleukodystrophy

    Individuals with CARASIL may develop a variety of symptoms relating to white matter involvement or leukoaraiosis (changes in deep white matter in the brain, which are observed[rarediseases.org] Other symptoms may include vision loss, learning disabilities, seizures, poorly articulated speech, difficulty swallowing, deafness, difficulty walking, poor coordination,[manninos.com] Symptoms may include progressive stiffness, weakness, or paralysis of the lower limbs and loss of coordination. Brain function deterioration may also been seen.[medical-dictionary.thefreedictionary.com]

  • Machado-Joseph Disease

    Magnetic resonance spectroscopy (MRS) of the deep white matter has demonstrated changes indicative of axonal dysfunction, although MRI in the same study did not reveal any[symptoma.com] walking due to muscle spasms (spastic gait) Poor reflexes Type III (MJD-III) Between 40-70 years of age Symptoms slowly worsen over time Muscle twitching Numbness, tingling[rarediseases.about.com] Despite much effort, a 74 year old man with progressive proximal weakness and sensory disturbances due to axonal neuropathy remained a diagnostic problem.[ncbi.nlm.nih.gov]

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