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133 Possible Causes for Abnormal Gait, Diffuse Hypomyelination

  • Pelizaeus-Merzbacher Disease

    He developed normally until 5 years of age when he began to deteriorate with scanning speech and gait abnormality. Auditory brainstem responses were normally preserved.[ncbi.nlm.nih.gov] Magnetic resonance imaging (MRI) of the brain revealed diffuse hypomyelination [Figure 1].[annalsofian.org] We present the case of a 26 year-old man who developed normally until he began having difficulty walking at age 12.[ncbi.nlm.nih.gov]

  • Cockayne Syndrome

    The abnormal gait is due to contractures of the ankles, knees and hips as well as leg spasticity and ataxia.[symptoma.com] Brain imaging reveals diffuse hypomyelination of the cerebral white matter, calcifications in the putamen, and vermian atrophy.[orpha.net] Changes were compatible with diffuse white matter hypomyelination. Basal ganglia calcification was present in both, marked cerebellar atrophy in the older patient.[ncbi.nlm.nih.gov]

  • Binswanger Disease

    The abnormality of gait that may occur in patients with subcortical arteriosclerotic encephalopathy is described in 12 patients in whom difficulty walking was the presenting[medigoo.com] […] with Atrophy 519 Hereditary Diffuse Leukoencephalo 526 Cerebral Amyloid Angiopathy 535 Cerebral Autosomal Dominant 541 Cerebral Autosomal Recessive 549 Pigmentary Orthochromatic[books.google.ro] Extrapyramidal disease Gait disturbance Low back pain Progressive encephalopathy Pseudobulbar signs Rigidity Abnormality of the skeletal system Low back pain Congenital anomaly[familydiagnosis.com]

  • Autosomal Recessive Spastic Paraplegia Type 18

    They all presented in the first 2 years of life with developmental delay, delayed walking, abnormal gait, and mild to severe mental retardation.[cags.org.ae] In SPG2, white matter abnormalities are also typical; they resemble (but to a lesser extent) the diffuse hypomyelination found in the allelic Pelizaeus-Merzbacher disease[scielo.br] […] disturbance Abnormal gait Abnormal walk Impaired gait [ more ] 0001288 Hyperreflexia Increased reflexes 0001347 Lower limb muscle weakness Lower extremity weakness Lower[rarediseases.info.nih.gov]

  • Hereditary Spastic Paraplegia

    HSP is a heterogeneous group of neurodegenerative disorders with progressive lower limb spasticity and weakness leading to abnormal gait as the principal clinical feature.[omicsonline.org] In SPG2, white matter abnormalities are also typical; they resemble (but to a lesser extent) the diffuse hypomyelination found in the allelic Pelizaeus-Merzbacher disease[scielo.br] Abnormal Gait- The disease is associated with an abnormal gait pattern, which progressively gets worse as the disease advances but total loss of ability to walk is an extremely[epainassist.com]

  • Congenital Muscular Dystrophy

    Persons affected with RSMD1 experience difficulty walking due to thigh muscle weakness, spinal rigidity, and mild Achilles tendon tightness.[disabled-world.com] Cerebral magnetic resonance imaging revealed diffuse hypomyelination in both cerebral hemispheres; electrophysiological assessment revealed progressive sensorimotor axonal[ncbi.nlm.nih.gov] The symptoms tend to progress slowly and include a loss of fine motor skills and difficulty walking.[healthline.com]

  • Hereditary Cerebellar Degeneration

    Clinical signs are varied, with some patients having limb and gait ataxia along with episodic headaches or nausea, and others having gait ataxia, speech difficulty, and abnormal[encyclopedia.com] Hypomyelination with congenital cataracts.[ajnr.org] walking, gait abnormalities, tremors, and heart problems.[ataxia.org]

  • Presenile Dementia with Bone Cysts

    […] of epiphysis morphology Bone pain Reduced bone mineral density Leukoencephalopathy Oculomotor apraxia Mental deterioration Hepatic steatosis Gait ataxia Adult onset Clonus[mendelian.co] Childhood ataxia with diffuse central nervous system hypomyelination. Ann Neurol 1994; 35: 331-340. (57.)[thefreelibrary.com] Prolonged prothrombin time Chorea Prolonged partial thromboplastin time Alzheimer disease Visual hallucinations Nevus Involuntary movements Vomiting Hydrocephalus Weight loss Gait[mendelian.co]

  • Autosomal Dominant Progressive External Ophthalmoplegia Type 6

    Progressive external ophthalmoplegia Obstructive sleep apnea Exertional dyspnea Generalized amyotrophy Sleep apnea Difficulty walking Apnea Dyspnea Tremor Elevated serum[mendelian.co] Diffuse hypomyelination. Imaging in MNGIE: Asymptomatic leukoencephalopathy. Prominent leukoencephalopathy in almost all patients. Corpus callosum is usually spared.[clinicaladvisor.com] Scapular winging Waddling gait Proximal muscle weakness Diaphyseal thickening Motor delay Peripheral axonal neuropathy Macrocephaly Gait disturbance Oxycephaly Dyspnea Skeletal[mendelian.co]

  • Hypomyelinating Leukodystrophy Type 5

    abnormalities, sexual dysfunction, and abnormalities of sphincter control.[clinicalgate.com] Brain magnetic resonance imaging show the combination of a diffuse hypomyelination with superimposed periventricular white matter signal abnormalities. this study describes[ncbi.nlm.nih.gov] In the intermediate stage (approximately 2–10 years), the white matter is diffusely abnormal with a background of diffuse hypomyelination ( Fig 2 ), in most patients associated[ajnr.org]

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