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100 Possible Causes for Abnormal Gait, Facial Muscle Weakness and Progressive Atrophy, Limb Weakness

  • Muscular Dystrophy

    Muscle weakness of the lower body, including the legs and pelvis area, slowly gets worse, causing: Difficulty walking that gets worse over time; by age 25 to 30, the person[web.archive.org] Abstract Facioscapulohumeral muscular dystrophy is an autosomal-dominant, slowly progressive myopathy that involves facial, shoulder, and upper arm muscles.[ncbi.nlm.nih.gov] The symptoms of FSH dystrophy may appear during childhood with severe facial and limb weakness or develop slowly and gradually in adulthood with progressive difficulty closing[kennedykrieger.org]

  • Myotonic Dystrophy

    A child with Duchenne MD may: have difficulty walking, running or jumping have difficulty standing up learn to speak later than usual be unable to climb the stairs without[nhs.uk] Clinical Presentation: Variable, progressive disability; facial and distal limb muscle weakness with myotonia; cataracts; cardiac conduction defects; diabetes mellitus; and[ajnr.org] Patient-reported perceived changes (worse/stable) in balance, walking, lower-limb weakness, stair-climbing and hand weakness were used as criteria.[ncbi.nlm.nih.gov]

  • Motor Neuron Disease

    Symptoms of SMA type III (Kugelberg-Welander disease) appear between 2 and 17 years of age and include abnormal gait; difficulty running, climbing steps, or rising from a[web.archive.org] Selective distal upper limb muscle weakness and atrophy with non-significant lower limb weakness during follow-up was the most frequent motor pattern, present in 18 patients[ncbi.nlm.nih.gov] In addition to changes in behavior, personality and language skills that characterize FTD, people with ALS and FTD also have difficulty walking, standing, using their hands[theaftd.org]

  • Adult Spinal Muscular Atrophy

    Later in life, abnormal gait and foot deformities are seen. Similar clinical signs occur in adult-onset forms.[encyclopedia.com] Spinal muscular atrophy is characterised by slowly progressive muscle weakness and atrophy of the limb muscles associated with motor neurone loss in the spinal cord.[patient.info] As the disease progresses patients may notice limb weakness starting in the pelvis or shoulders, or weakness of the facial and tongue muscles.[cedars-sinai.edu]

  • Spinal Muscular Atrophy

    Later in life, abnormal gait and foot deformities are seen. Similar clinical signs occur in adult-onset forms.[encyclopedia.com] Spinal muscular atrophy is characterised by slowly progressive muscle weakness and atrophy of the limb muscles associated with motor neurone loss in the spinal cord.[patient.info] As the disease progresses patients may notice limb weakness starting in the pelvis or shoulders, or weakness of the facial and tongue muscles.[cedars-sinai.edu]

  • Young Adult-Onset Distal Hereditary Motor Neuropathy

    gait.[now.aapmr.org] weakness DHMN8 600175 TRPV4 12q24.11 Autosomal dominant Congenital distal spinal muscular atrophy Affects primarily distal muscles of lower limbs, non-progressive, rare DHMNJ[en.wikipedia.org] Lower limb and upper limb weakness is common, beginning towards the hands and feet and sometimes extending above the elbows and knees.[cmtausa.org]

  • Lower Motor Neuron Syndrome with Late-Adult Onset

    SMA type III appears between two and 17 years of age and includes abnormal gait, difficulty running, climbing steps, rising from a chair, and fine tremor of the fingers.[advancedpsy.com] In family A the pathological findings and the clinical presentation with symmetrical proximal limb weakness show similarities with autosomal dominant SMA.[link.springer.com] walking Breathing and swallowing difficulties are very rare and the condition does not usually affect life expectancy Over time, muscles become weaker resulting in children[thehumanthebody.com]

  • Limb-Girdle Muscular Dystrophy Type 2A

    COMMON Features of the Disorder Difficulty walking Wheelchair assistance Scoliosis Joint contractures Muscle cramps Exercise intolerance Cardiomyopathy (weak heart muscles[evolvegene.com] There is often asymmetric quadriceps, hamstring, biceps, brachioradialis, or calf weakness and atrophy. Muscle pain is common.[emedicine.medscape.com] […] muscle weakness Lower extremity weakness Lower limb weakness Muscle weakness in lower limbs [ more ] 0007340 Muscular dystrophy 0003560 Pectoralis amyotrophy Wasting of pec[rarediseases.info.nih.gov]

  • Autosomal Dominant Progressive External Ophthalmoplegia Type 6

    Progressive external ophthalmoplegia Obstructive sleep apnea Exertional dyspnea Generalized amyotrophy Sleep apnea Difficulty walking Apnea Dyspnea Tremor Elevated serum[mendelian.co] PEO6 DNA2 AD PEO w/variable, slowly progressive features; onset: childhood-adulthood Slender build Facial muscle weakness; exertional dyspnea; obstructive sleep apnea; myopathy[ncbi.nlm.nih.gov] Exercise intolerance, limb weakness, hearing loss, and diabetes may also precede the occurrence of the stroke-like episodes.[umdf.org]

  • Amyotrophic Lateral Sclerosis

    He had difficulty walking due to poor movement of his right leg, and was diagnosed as having Parkinson's disease because of akinesia.[ncbi.nlm.nih.gov] In cranial nerves, common symptoms are atrophy of facial muscles and progressive bulbar palsy (PBP).[flexikon.doccheck.com] We report the case of a 61-year-old man who presented with progressively worsening limb weakness and dysphagia.[ncbi.nlm.nih.gov]

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