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30 Possible Causes for Abnormal Gait, Neuronal Loss and Gliosis in the Inferior Olives

  • Hereditary Cerebellar Degeneration

    Clinical signs are varied, with some patients having limb and gait ataxia along with episodic headaches or nausea, and others having gait ataxia, speech difficulty, and abnormal[encyclopedia.com] Microscopic examination of these structures reveals neuronal loss, axon and myelin degeneration, and gliosis.[neuropathology-web.org] walking, gait abnormalities, tremors, and heart problems.[ataxia.org]

  • Dentatorubral-Pallidoluysian Atrophy

    Patient 2 Patient 2 developed loss of visual acuity at the age of 22 years and gait disturbance at age 23 years.[doi.org] Neuropathological examination showed severe neuronal loss associated with gliosis in the inferior olive and cerebellar Purkinje cell layer.[doi.org] At age 28 years, optic atrophy was prominent, and evoked auditory potentials indicated abnormal conduction in the pons.[doi.org]

  • Friedreich Ataxia

    Related Cases Disease: Friedreich’s Ataxia Degenerative Nerve Diseases Symptom/Presentation: Ataxia, Dizziness, and Vertigo Abnormal Gait Specialty: Genetics Medical History[pediatriceducation.org] Microscopic examination of these structures reveals neuronal loss, axon and myelin degeneration, and gliosis.[neuropathology-web.org] A 10-year-old boy presented with congenital biliary atresia and progressive gait abnormality.[ncbi.nlm.nih.gov]

  • Creutzfeldt Jakob Disease

    People with CJD will have ataxia, or difficulty controlling body movements, abnormal gait, speech, and dementia. It is always fatal, and there is no cure.[medicalnewstoday.com] & neuronal loss involving medial dorsal & anterior ventral thalamic nuclei & inferior olive; spongiform degeneration is minimal & focal VPSPr Median 70, 79 SD 9, 79 range[doi.org] Symptoms may include behavior changes, confusion, memory problems, stiff muscles, loss of feeling in arms, legs or face, loss of balance, difficulty walking, muscle spasms[nj.gov]

  • Cerebellar Ataxia

    The study reports that among the remaining 29 patients, 25 required no gait aid, but had an abnormal gait, and four patients had normal gait. ### About Mayo Clinic Mayo Clinic[eurekalert.org] Microscopic examination of these structures reveals neuronal loss, axon and myelin degeneration, and gliosis.[neuropathology-web.org] Autosomal recessive, X-linked, autosomal dominant Cerebellar ataxias are a highly heterogeneous group of genetic disorders distinguished by abnormal wide-based gait, irregular[centogene.com]

  • Ataxia

    gaits Foot Abnormality[en.wikipedia.org] Microscopic examination of these structures reveals neuronal loss, axon and myelin degeneration, and gliosis.[neuropathology-web.org] In addition, mild secondary neuronal cell loss with gliosis was noted in the dentate nucleus and inferior olive.[doi.org]

  • Olivopontocerebellar Atrophy

    Dysfunctions of the cerebellum may lead to an abnormal gait or other motor function problems.[news-medical.net] There is neuronal loss and gliosis in the inferior olives, pons, cerebellum, substantia nigra, locus ceruleus, striatum and the intermediolateral column of the spinal cord[dizziness-and-balance.com] Microscopic examination of these structures reveals neuronal loss, axon and myelin degeneration, and gliosis.[neuropathology-web.org]

  • Striatonigral Degeneration

    Other symptoms may include the following: Constipation Diarrhea Difficulties breathing or swallowing Difficulty walking Double vison or other vision problems Erectile dysfunction[healthcommunities.com] There is neuronal loss and gliosis in the inferior olives, pons, cerebellum, substantia nigra, locus ceruleus, striatum and the intermediolateral column of the spinal cord[dizziness-and-balance.com] Consequently, they have difficulty walking and take wide, irregular steps. When reaching for an item, they may reach beyond it. When sitting, they may feel unstable.[merckmanuals.com]

  • Adult-Onset Autosomal Recessive Cerebellar Ataxia

    Autosomal recessive, X-linked, autosomal dominant Cerebellar ataxias are a highly heterogeneous group of genetic disorders distinguished by abnormal wide-based gait, irregular[centogene.com] Microscopic examination of these structures reveals neuronal loss, axon and myelin degeneration, and gliosis.[neuropathology-web.org] walking, gait abnormalities, tremors, and heart problems.[ataxia.org]

  • Autosomal Recessive Spinocerebellar Ataxia

    Autosomal recessive, X-linked, autosomal dominant Cerebellar ataxias are a highly heterogeneous group of genetic disorders distinguished by abnormal wide-based gait, irregular[centogene.com] Microscopic examination of these structures reveals neuronal loss, axon and myelin degeneration, and gliosis.[neuropathology-web.org] walking, gait abnormalities, tremors, and heart problems.[ataxia.org]

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