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83 Possible Causes for Abnormal Gait, Severe Mental Retardation in Some Patients

  • Dravet Syndrome

    In severe cases, patients may present with profound neurological deficit including hypotonia, seizures and mental retardation.[ncbi.nlm.nih.gov] Developmental delays appear to different degrees in the majority of people with Dravet syndrome by the age of 2 and ataxia or abnormal gait is common.[disabled-world.com] Gait abnormalities seem to worsen during adolescence. Seizures tend to decrease in number and duration with age.[ninds.nih.gov]

  • Cerebral Palsy

    Many of the infants born with cerebral palsy also experience some degree of mental retardation and/or have seizures.[my.clevelandclinic.org] Structural changes in muscle and fascia may play a role in abnormal gait.[ncbi.nlm.nih.gov] These comorbidities include intellectual disabilities, seizures, muscle contractures, abnormal gait, osteoporosis, communication disorders, malnutrition, sleep disorders,[ncbi.nlm.nih.gov]

  • Pelizaeus-Merzbacher Disease

    retardation is not severe, some patients show dementia or personality disorders, the disease is progressive rather than static in some, and several females show signs of[ncbi.nlm.nih.gov] He developed normally until 5 years of age when he began to deteriorate with scanning speech and gait abnormality. Auditory brainstem responses were normally preserved.[ncbi.nlm.nih.gov] We present the case of a 26 year-old man who developed normally until he began having difficulty walking at age 12.[ncbi.nlm.nih.gov]

  • Glycogen Storage Disease Type 2

    Some reported “intermediate” patients as having mental retardation, whereas others did not. 258 , 259 Individuals throughout the spectrum of phenotype severity have been reported[dx.doi.org] abnormalities Muscle pain Difficulty climbing stairs Frequent falls Scapular winging Respiratory Frequent infections Respiratory insufficiency Cardio-respiratory failure[cuh.nhs.uk] walking 15 (16%) • Difficulty rising from an armchair 11 (12%) • Difficulty rising from a lying position 9 (10%) Fatigue 17 (18%) Muscle soreness / cramps 16 (17%) Respiratory[ojrd.com]

  • Autosomal Recessive Spastic Paraplegia Type 35

    Complex hereditary spastic paraplegia, on the other hand, is characterized by the presence of several more conditions some of which are dementia, epilepsy and mental retardation[ic.steadyhealth.com] Furthermore, among the core symptoms of HSP are also included abnormal gait and difficulty in walking, decreased vibratory sense at the ankles, and paresthesia. [13] Initial[ipfs.io] Furthermore, among the core symptoms of HSP are also included abnormal gait and difficulty in walking, decreased vibratory sense at the ankles, and paresthesia. [10] Individuals[en.wikipedia.org]

  • Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2A

    Additionally in recent years several data have implicated minor mutations in this gene region in some patients with mental retardation (MR).[connection.ebscohost.com] COMMON Features of the Disorder Difficulty walking Wheelchair assistance Scoliosis Joint contractures Muscle cramps Exercise intolerance Cardiomyopathy (weak heart muscles[evolvegene.com] Get Update Overview Autosomal recessive limb-girdle muscular dystrophy-1 affects primarily the proximal muscles, resulting in difficulty walking.[diseaseinfosearch.org]

  • Congenital Muscular Dystrophy

    […] calf hypertrophy, microcephaly, and mental retardation.[ncbi.nlm.nih.gov] Persons affected with RSMD1 experience difficulty walking due to thigh muscle weakness, spinal rigidity, and mild Achilles tendon tightness.[disabled-world.com] Most individuals are able to walk independently although because of progressive spinal rigidity and scoliosis they may experience difficulties walking later during life.[rarediseases.org]

  • Deletion of the Long Arm of Chromosome 18

    abnormalities (68%) Ear anomalies Narrow or atretic auditory canals (39-64%) Prominent antihelix or antitragus (58%) Low-set ears (8%) Foot deformities (51-74%) Club foot[en.wikibooks.org] All of these bone problems can affect the way they walk and may lead to gait abnormalities. People with foot, knee, or spinal changes may see an orthopedic specialist.[justjamesinfo.wordpress.com] Decreased or absent deep tendon reflexes (76%) Short stature (61-77% of patients are below the fifth percentile) Hearing impairment (70%) Mental retardation IQ 70 (68%) Gait[en.wikibooks.org]

  • Ataxia

    […] have seizures and mild mental retardation.[pn.bmj.com] gait or difficulty walking, nausea, and vomiting.[glutenfreesociety.org] Cerebellar ataxia differs from gait problems due to abnormalities in other parts of the nervous system, such as the abnormal gait seen in Parkinson’s disease, normal pressure[hopkinsmedicine.org]

  • Wolfram Syndrome

    We present two unrelated patients with Wolfram syndrome, both of whom had the four cardinal features and several other neurologic abnormalities.[ncbi.nlm.nih.gov] Compared to normative data, the WFS group had intact cognition, significant anxiety and depression, and gait abnormalities.[ncbi.nlm.nih.gov] BACKGROUND: Classically characterized by early onset insulin-dependent diabetes mellitus, optic atrophy, deafness, diabetes insipidus, and neurological abnormalities, Wolfram[ncbi.nlm.nih.gov]

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