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32 Possible Causes for Abnormal Gait, Vacuolation of Granular Layer

  • Binswanger Disease

    The abnormality of gait that may occur in patients with subcortical arteriosclerotic encephalopathy is described in 12 patients in whom difficulty walking was the presenting[medigoo.com] Pick bodies (granular layer of dentate gyrus). Extensive astrogliosis (striatonigral degeneration, hepatic encephalopathy).[librepathology.org] Extrapyramidal disease Gait disturbance Low back pain Progressive encephalopathy Pseudobulbar signs Rigidity Abnormality of the skeletal system Low back pain Congenital anomaly[familydiagnosis.com]

  • Barth Syndrome

    […] whorled layers of cristae.[medlink.com] Histologic examination of the heart in patients showed swollen fibers, partial loss of cross striations, central granular material, and bizarre mitochondria with stacked or[medlink.com] Skeletal muscle had a number of nonspecific histological changes, such as mildly increased fat vacuolization of type 1 fibers; bone marrow aspirates demonstrate maturational[medlink.com]

  • Bullous Erythroderma Ichthyosiformes

    Our case fits into the NPS-2 type, based on the widespread involvement, the brown scales, the lack of palmoplantar keratoderma, and the lack of gait abnormality.[ommegaonline.org] These become mature corps ronds by further vacuolization when in the granular layer.[ijdpdd.com] […] and hyperkeratosis with ballooning degeneration of the granular and spinous layers of the epidermis [2].[medresearch.in]

  • Coronary Cataract

    The child has difficulty walking or grasping. Erratic eye movement is present.[alpfmedical.info] Characteristically, these forms of senile opacity are usually restricted to a single layer and are composed of vacuoles and granular material.[embryology.med.unsw.edu.au]

  • Limb-Girdle Muscular Dystrophy

    This means that people may have frequent falls, and may have difficulty walking longer distances, climbing stairs and getting up from the floor.[musculardystrophyuk.org] Contains Granular material Complement deposits Sarcolemma & vacuoles Granular pattern X-linked Vacuolar Cardiomyopathy and Myopathy (Danon's disease) Lysosome-associated[neuromuscular.wustl.edu] The symptoms of an individual with limb-girdle muscular dystrophy (LGMD) generally has great difficulty walking, going both up and down stairs and raising from a chair.[en.wikipedia.org]

  • Diffuse Palmoplantar Keratoderma

    Oftentimes, keratodermas create walking difficulties, as the pain causes an abnormal gait.[footfiles.com] Large keratohyalin granules are seen in the spinous and granular cell layers. The eccrine glands may exhibit hypertrophy.[clinicaladvisor.com] Cellular breakdown in the spinous and granular cell layers occurs rarely and can lead to blister formation.[emedicine.medscape.com]

  • Verruca Vulgaris

    Orthotic inserts can help correct poor foot biomechanics by controlling the position of the foot during the gait cycle and preventing abnormal pressure on parts of the foot[sportsinjuryclinic.net] layer with vacuolated superficial keratinocytes with pyknotic nuclei (koilocytes) Dilated blood vessels within papillary dermis Tiers of parakeratosis overly papillary epidermal[pathologyoutlines.com] Cells with prominent perinuclear vacuolization around pyknotic, basophilic, centrally located nuclei can be in the granular layer.[ncbi.nlm.nih.gov]

  • Howell-Evans Syndrome

    Oftentimes, keratodermas create walking difficulties, as the pain causes an abnormal gait.[footfiles.com] Cellular breakdown in the spinous and granular cell layers occurs rarely and can lead to blister formation.[emedicine.medscape.com] Perinuclear vacuolization and large keratohyalin granules are seen.[emedicine.medscape.com]

  • Lytic Bone Lesion

    His parents had no abnormal skeletal manifestations.[nature.com] Cellular breakdown in the spinous and granular cell layers occurs rarely and can lead to blister formation.[emedicine.medscape.com] He was 170 cm tall, had no facial dysmorphism, a normal gait, and demonstrated no restriction in joint movements or propensity to fractures.[nature.com]

  • Palmoplantar Keratosis

    […] of the testis Cystic hygroma Acute myeloid leukemia Hypoglycemia Muscle weakness Dysarthria Hyperreflexia Nevus Epicanthus Visual impairment Spasticity Cleft palate Gait[mendelian.co] […] irregularly shaped keratohyalin granules located in the granular layer of the epidermis and perinuclear vacuolization of the keratinocytes.[ncbi.nlm.nih.gov] Cellular breakdown in the spinous and granular cell layers occurs rarely and can lead to blister formation.[emedicine.com]

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