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90 Possible Causes for Abnormal Mitochondria Morphology

  • Scoliosis

    Abstract The mitochondrial myopathies include a diverse group of disorders characterized by morphological abnormalities of muscle mitochondria.[ncbi.nlm.nih.gov]

  • Follicular Thyroid Carcinoma

    Medullary and poorly differentiated carcinomas may also display oncocytic features. 9, 10, 66, 67 Hürthle cells are stuffed with the mitochondria with morphological, functional[nature.com] Medullary and poorly differentiated carcinomas may also display oncocytic features. 9 , 10 , 66 , 67 Hürthle cells are stuffed with the mitochondria with morphological, functional[nature.com] […] and genetic abnormalities. 9, 10, 66, 67 The accumulation of the mitochondria may be due to a primary alteration of mitochondrial DNA or of nuclear DNA that encode mitochondrial[nature.com]

  • Differentiated Thyroid Gland Carcinoma

    Medullary and poorly differentiated carcinomas may also display oncocytic features. 9, 10, 66, 67 Hürthle cells are stuffed with the mitochondria with morphological, functional[nature.com] […] and genetic abnormalities. 9, 10, 66, 67 The accumulation of the mitochondria may be due to a primary alteration of mitochondrial DNA or of nuclear DNA that encode mitochondrial[nature.com]

  • Familial Visceral Myopathy

    abnormalities of muscle mitochondria.[onlinelibrary.wiley.com] […] clinically heterogeneous disorders that can affect multiple systems besides skeletal muscle ( mitochondrial encephalomyopathies or cytopathies ) and are usually defined by morphological[onlinelibrary.wiley.com]

  • Central Sleep Apnea

    His myocardium was hypertrophic and the ultrastructural analysis showed morphologically abnormal mitochondria.[ncbi.nlm.nih.gov]

  • Myelodysplasia

    RARS is defined morphologically as having 15% erythroid cells with abnormal ringed sideroblasts (see the image below), reflecting an abnormal accumulation of iron in the mitochondria[emedicine.com]

  • MELAS Syndrome

    This is the first report of a MELAS syndrome patient with skin manifestations and evidence of morphologically abnormal mitochondria.[ncbi.nlm.nih.gov] Diverse clinical disorders associated with morphological abnormalities of mitochondria. In: Cerri C, Scarlato G (eds). Mitoehondrial Pathology in Muscle Diseases .[link.springer.com] Electron microscopy revealed marked increase in the number of morphologically abnormal mitochondria in the arrector muscles of the involved skin.[ncbi.nlm.nih.gov]

  • Amyotrophic Lateral Sclerosis

    Abnormal mitochondrial transport and morphology are common pathological denominators in SOD1 and TDP43 ALS mouse models. Hum. Mol. Genet. 23, 1413–1424 (2014). 119.[doi.org] Mitochondrial dysfunction Abnormalities in mitochondrial morphology and biochemistry have been reported in sporadic ALS patients, SOD1 transgenic mice and cellular models[doi.org] Misfolded SOD1 associated with motor neuron mitochondria alters mitochondrial shape and distribution prior to clinical onset. PLoS ONE 6, e22031 (2011). 118.[doi.org]

  • Leigh's Disease

    Ultrastructural examination of skeletal muscles biopsies revealed a spectrum of morphological abnormalities consisting mainly of more or less detectable mitochondrial alterations[doi.org] Ultrastructural abnormalities found by us were similar to these seen in the animal model of the disease. 47 However it is not possible to identify any morphological or ultrastructural[doi.org] In a majority of patients (12 of 19 examined cases), several muscle fibres demonstrated distinct subsarcolemmal accumulation of altered mitochondria ( fig 2B,C ).[doi.org]

  • Thyroid Follicular Adenoma

    Medullary and poorly differentiated carcinomas may also display oncocytic features. 9, 10, 66, 67 Hürthle cells are stuffed with the mitochondria with morphological, functional[nature.com] […] and genetic abnormalities. 9, 10, 66, 67 The accumulation of the mitochondria may be due to a primary alteration of mitochondrial DNA or of nuclear DNA that encode mitochondrial[nature.com]

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