Abnormal-pigmentation: Causes & Reasons

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Possible Causes for abnormal pigmentation

Skin Atrophy

Abstract Kindler Syndrome (KS), characterized by transient skin blistering followed by abnormal pigmentation, skin atrophy, and skin cancer, is caused by mutations in the [ncbi.nlm.nih.gov]

Rarely, patches of skin on the arms, legs, and/or trunk may have similar pigmentation abnormalities. [rarediseases.org]

Some affected individuals have a condition called vitiligo, a skin condition in which loss of color (pigmentation) of areas of skin results in the development of abnormal [rarediseases.org]

Discoid Lupus Erythematosus

Malignant transformation of DLE is rare, however, skin cancer may be more common among blacks because of the absence of pigmentation in the chronic lesions, coupled with the [symptoma.com]

[…] a detailed evaluation to detect serologic abnormalities, hematologic disorders, serosal inflammation such as pleuritis and pericarditis, neurological sequalae, and renal abnormalities [symptoma.com]

Dyskeratosis Congenita

Abstract Dyskeratosis congenita is characterised by abnormal pigmentation of skin, dystrophy of nails, and mucosal leukoplakia mainly on the tongue. [ncbi.nlm.nih.gov]

It is also characterized by triad of abnormal skin pigmentation, nail dystrophy and mucosal leukoplakia. [ncbi.nlm.nih.gov]

Dyskeratosis congenita is an unusual inherited disease characterized by the triad of abnormal skin pigmentation, nail dystrophy and mucosal leukoplakia. [ncbi.nlm.nih.gov]

3q29 Microdeletion

Additional features-including microcephaly, cleft lip and palate, horseshoe kidney and hypospadias, ligamentous laxity, recurrent middle ear infections, and abnormal pigmentation-were [research.manchester.ac.uk]

pigmentation Genes involved The deletion encompasses 22 genes, including PAK2 DLG1 References Willatt L, Cox J, Barber J, Cabanas ED, Collins A, Donnai D, Fitzpatrick DR, [humpath.com]

Additional features--including microcephaly, cleft lip and palate, horseshoe kidney and hypospadias, ligamentous laxity, recurrent middle ear infections, and abnormal pigmentation [ncbi.nlm.nih.gov]

Dubin-Johnson Syndrome

Dubin-Johnson syndrome may manifest as conjugated hyperbilirubinemia, darkly pigmented liver, presence of abnormal pigment in the parenchyma of hepatocytes and abnormal distribution [ncbi.nlm.nih.gov]

[…] of abnormal pigment in hepatic parenchymal cells. [ncbi.nlm.nih.gov]

[…] liver and the presence of abnormal pigment in hepatic parenchymal cells. [ 1 ] Dubin-Johnson syndrome was first described by Dubin and Johnson in 1954 and independently by [patient.info]

Vulvitis

[…] or vascular abnormalities. [ncbi.nlm.nih.gov]

Lichen aureus is localized variant of persistent pigmented purpuric dermatitis that typically affects the legs and can be associated with delayed hypersensitivity reactions [ncbi.nlm.nih.gov]

Vitamin B12 Deficiency

In addition to neurological symptoms, infants may experience other physical symptoms, including abnormal pigmentation, hypotonia, enlarged liver and spleen, sparse hair, food [ncbi.nlm.nih.gov]

Nonneurologic manifestations include the following: General - Lemon-yellow waxy pallor, premature whitening of hair, flabby bulky frame, mild icterus, and blotchy skin pigmentation [emedicine.medscape.com]

[…] patients Cardiovascular - Tachycardia, congestive heart failure Gastrointestinal - Beefy, red, smooth, and sore tongue with loss of papillae that is more pronounced along edges Abnormal [emedicine.medscape.com]

Constipation

Abstract Waardenburg syndrome is characterized by hearing loss, pigmentation abnormalities, dysmorphologic features, and neurological phenotypes. [ncbi.nlm.nih.gov]

Prolonged use of stimulant laxatives can create abnormal deposits of a dark pigment in the lining of the large intestine (a condition called melanosis coli). [merck.com]

Actinic Keratosis

Discoid lupus erythematosus (shows abnormal pigmentation, dilated follicles and atrophy). [patient.info]

Rosacea

Pigmentary deposition is another problem, which results when the skin turns abnormal pigments (usually very light) permanently. 6. [draxe.com]

Anemia

Sickle cell anemia is an inherited disorder in which abnormal hemoglobin (the red pigment inside red blood cells) is produced. [mountsinai.org]

The abnormal hemoglobin causes red blood cells to assume a sickle shape, like the ones seen in this photomicrograph. Red blood cells (RBCs) are normally round. [mountsinai.org]

Acne Vulgaris

pigmented vascular skin lesions, abnormal skin pigmentation, or body art (tattoos, permanent or temporary) on the face, which could interfere with subsequent study evaluations [ncbi.nlm.nih.gov]

pigmentation Adverse effects of tetracyclines might be serious and sometimes unknown. [doi.org]

Presence of facial nodules and “cysts” Female patients who were pregnant, nursing or planning a pregnancy during the study Facial hair, a degree of skin pigmentation, abnormal [ncbi.nlm.nih.gov]

Ovarian Cyst

[…] of bone structure and skin pigmentation. [medical-dictionary.thefreedictionary.com]

McCune-Albright syndrome (MCAS) — A genetic syndrome characterized in girls by the development of ovarian cysts and puberty before the age of 8, together with abnormalities [medical-dictionary.thefreedictionary.com]

Dermatitis

These patients should also report to their health care prpfessionals any peculiar skin abnormalities, including abnormally pigmented areas and skin that is changing color [medicinenet.com]

These patients should also report to their health-care practitioners any peculiar skin abnormalities, including abnormally pigmented areas and skin that is changing color [web.archive.org]

pigmentation. [britannica.com]

Gardner Syndrome

[…] of skin pigmentation Abnormal pigmentation Abnormal skin color Abnormal skin pigmentation Abnormality of pigmentation Pigmentary changes Pigmentary skin changes Pigmentation [rarediseases.info.nih.gov]

These may include high risk screening, prophylactic surgeries and/or certain types of medications. 0012032 Thyroid nodule 0025388 5%-29% of people have these symptoms Abnormality [rarediseases.info.nih.gov]

Familial Cutaneous Collagenoma

Abnormality of skin pigmentation Abnormal pigmentation Abnormal skin color Abnormal skin pigmentation Abnormality of pigmentation Pigmentary changes Pigmentary skin changes [rarediseases.info.nih.gov]

Symptoms related to Familial cutaneous collagenoma include: Skin pigmentation abnormality Genital system abnormality Aplasia Hypoplasia of the iris Iris atrophy Testicular [familydiagnosis.com]

pigmented lesions, short stature, microcephaly, and learning disabilities. [dermatologyadvisor.com]

Ganglion Cyst

Physical examination may reveal edema with tenderness; however, there are usually no abnormal findings. [spandidos-publications.com]

[…] but it must be differentially diagnosed from a unicameral bone cyst, aneurysmal bone cyst, chondromyxoid fibroma, Brodie's abscess, giant-cell tumor, fibrous dysplasia and pigmented [spandidos-publications.com]

Carney Complex

It is associated with many other nonendocrine tumors, including cardiac myxomas, testicular tumors, melanotic schwannoma, breast myxomatosis, and abnormal pigmentation or [ncbi.nlm.nih.gov]

It is associated with many other nonendocrine tumors, including cardiac myxomas, testicular tumors, melanotic schwannoma, breast myxomatosis, and abnormal pigmentation (lentiginosis [ncbi.nlm.nih.gov]

First described in 1985, Carney complex is a rare, heritable disorder featuring abnormal skin pigmentation, cardiac and cutaneous myxoma, melanotic schwannoma of psammomatous [ncbi.nlm.nih.gov]

Osteitis Fibrosa Disseminata

Albright like syndrome, Osteitis fibrosa disseminata, Polyostotic, fibrous dysplasia, Precocious puberty with polyostotic fibrosis and abnormal pigmentation, MAS, PFD, POFD [checkorphan.org]

A condition affecting one, several or many bones, the graver cases of which may present with abnormal pigmentation of skin, premature sexual development, hyperthyroidism or [whonamedit.com]

Pigmentation. [amazon.in]

Hemochromatosis

Hemochromatosis can cause arthritis, liver disease, damage to the pancreas and adrenal gland, heart abnormalities, impotence, premature menopause, abnormal pigmentation of [diabetesselfmanagement.com]

such as irregular heart rhythms or congestive heart failure impotence early menopause abnormal pigmentation of the skin, making it look gray or bronze pituitary damage damage [liverfoundation.org]

[…] serious problems such as: arthritis liver disease, including an enlarged liver, cirrhosis, cancer, and liver failure damage to the pancreas, possibly causing diabetes heart abnormalities [liverfoundation.org]

Hoyeraal-Hreidarsson Syndrome

pigmentation changes to the upper chest/neck, eye abnormalities, dental abnormalities, developmental delay, cerebellar hypoplasia, bilateral exudative retinopathy, and intracranial [secure.ssa.gov]

pigmentation changes to the upper chest/neck; • Bilateral exudative retinopathy; and • Intracranial calcifications. [secure.ssa.gov]

DC is a clinically heterogeneous disorder diagnosed by the triad of dysplastic nails, abnormal skin pigmentation, and oral leukoplakia; Hoyeraal-Hreidarsson syndrome (HH), [ncbi.nlm.nih.gov]

Hypogonadism

joint pains, diabetes, or abnormal liver blood tests, rather than through familial screening or serendipity (65% before 1996 vs. 41% after; by Pearson’s χ 2 test, P 0.018 [academic.oup.com]

[…] we found that significantly more patients presented in the earlier period of the study because of the presence of symptoms or complications of the disease, such as skin pigmentation [academic.oup.com]

Klein-Waardenburg Syndrome

His mother’s aunt showed a lateral iris pigmentation abnormality (Figure 1a:14), and his mother’s elder sister showed a lateral iris pigmentation abnormality and bilateral [nature.com]

abnormalities Abnormalities of hair pigmentation, such as white forelock, eyebrows, or eyelashes Dystopia canthorum – lateral displacement of inner canthi First degree relative [dermnetnz.org]

pigmentation of the fundus Type 2 Type 2 has similar clinical features to type 1 Waardenburg syndrome, but the inner canthi are normal. [dermnetnz.org]

Ermine Phenotype

Ermine phenotype has a distinct clinical presentation compared to other syndromes associated with abnormal pigment and deafness. [ncbi.nlm.nih.gov]

Overview Ermine phenotype: A very rare syndrome characterized by pigmentation abnormalities as well as deafness. [checkorphan.org]

[…] posturing Retrocollis Abnormality of skin pigmentation Nystagmus-induced head nodding Neoplasm of the skin Freckling Iris hypopigmentation Pendular nystagmus Abnormal pupil [mendelian.co]

Scoliosis

pigmentation, e.g., café-au-lait spots, a sign of neurofibromatosis. [doi.org]

[…] pronounced focal growth of hair over the lumbar spine frequently accompanies incomplete fusion of the laminae and can indicate a neurological cause of scoliosis, as can abnormal [doi.org]

Fibroma

Mental retardation Hypogonadism Occular and cardiovascular abnormalities Epidemiology Non-ossifying fibroma can be present in up to 30% of children. [orthopaedicsone.com]

Finally, the retinal examination of the child showed no signs of congenital hypertrophy of the retinal pigment epithelium (CHRPE). [onlinelibrary.wiley.com]

[…] location metaphysis of long bones 80% in lower extremity distal femur proximal tibia distal tibia uncommon in proximal femur, proximal humerus Pathophysiology possibly due to abnormal [orthobullets.com]

Puerperium

Posterior segment examination: Example, abnormal retinal pigmentation seen in Kearn-Sayre syndrome Cogan's lid twitch: Elicited by having the patient look in downgaze, followed [kjophthal.com]

abnormal stress response). 37 Many of these symptoms overlap common postpartum findings, so the diagnosis may be elusive, especially if necrosis is incomplete and areas [glowm.com]

[…] superinvolution” of the uterus, infertility, hypothyroidism (fatigue, cold intolerance, edema), and adrenocortical insufficiency (fatigue, anorexia, weight loss, decreased skin pigmentation [glowm.com]

Third Trimester Pregnancy

Bednar tumors, often called pigmented dermatofibrosarcoma protuberans, contain dark-colored (pigmented) cells called melanin-containing dendritic cells. [ghr.nlm.nih.gov]

Myxoid dermatofibrosarcoma protuberans tumors contain an abnormal type of connective tissue known as myxoid stroma. [ghr.nlm.nih.gov]

Raynaud Syndrome

When present in the digits, these abnormalities produce changes in the contour of the fingers and toes, referred to as sclerodactyly. [clinicalgate.com]

Other manifestations of systemic sclerosis include pitting scars of the tips of the digits, normal skin pigmentation, and telangiectasia. [clinicalgate.com]

Bloch Sulzberger Syndrome

The retinal pigment epitheliopathy and the abnormalities of retinal vessels are thought to be the underlying pathognomonic findings, with all other ocular signs being secondary [ncbi.nlm.nih.gov]

Abnormalities of the retinal pigment epithelium, including peripheral hypopigmented areas, have been reported occasionally in patients with IP. [ncbi.nlm.nih.gov]

However, there is no inflammatory stage preceding the abnormal pigmentation in HI. [cancertherapyadvisor.com]