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11 Possible Causes for Abnormal Saccades, Disturbance of Coordination, Interictal Downbeat Nystagmus

  • Autosomal Recessive Spinocerebellar Ataxia 8

    […] in ocular saccades attention defects impaired verbal working memory and visuospatial skills Normal life expectancy Autosomal recessive ataxias are generally associated with[en.wikipedia.org] According to Baloh and others (1997), EA2 is characterized by a progressive ataxia with interictal rebound nystagmus evoked by gaze, as well as downbeating nystagmus.[tchain.com] The result is a lack of coordination and balance, or disturbance in their gait.[disabled-world.com]

  • Episodic Ataxia

    It is characterized by episodic ataxia (of course), rebound nystagmus, saccadic overshoot dysmetria, abnormal pursuit and optokinetic nystagmus, and normal semicircular canal[dizziness-and-balance.com] Ataxia is characterized by disturbances in the voluntary coordination of posture and movement.[healio.com] Gait ataxia, dysarthria, dysmetria, nystagmus, peripheral neuropathy, muscle wasting, and dystonia in late stages of the disease Gain of function mutation, resulting in an abnormal[emedicine.com]

  • Spinocerebellar Ataxia Type 6

    CONCLUSIONS: Among the earliest functional deficits in SCA6 are eye movement abnormalities, including impaired saccade velocity, saccade metrics, and pursuit gain.[ncbi.nlm.nih.gov] Initial examination disclosed a central type of positional nystagmus (conjugate downbeat nystagmus that did not fatigue with repeated positioning).[jnnp.bmj.com] The result is a lack of coordination and balance, or disturbance in their gait.[disabled-world.com]

  • Early-Onset Cerebellar Ataxia

    Apart from cerebellar signs and brisk knee jerks in all, other important findings were abnormal ocular movements (mostly impaired saccades) in 92.8%, Babinski's sign (78.6%[ncbi.nlm.nih.gov] . ; EA2 with interictal nystagmus , is long-lasting (hours) associated with attacks of vertigo, diffuse weakness, slurred speech, dystonia, seizures, truncal and limb ataxia[neuroweb.us] The result is a lack of coordination and balance, or disturbance in their gait.[disabled-world.com]

  • Adult-Onset Autosomal Recessive Cerebellar Ataxia

    […] in ocular saccades attention defects impaired verbal working memory and visuospatial skills Normal life expectancy Autosomal recessive ataxias are generally associated with[en.wikipedia.org] . ; EA2 with interictal nystagmus , is long-lasting (hours) associated with attacks of vertigo, diffuse weakness, slurred speech, dystonia, seizures, truncal and limb ataxia[neuroweb.us] The result is a lack of coordination and balance, or disturbance in their gait.[disabled-world.com]

  • Spinocerebellar Ataxia Type 4

    Gait ataxia, dysarthria, dysmetria, nystagmus, peripheral neuropathy, muscle wasting, and dystonia in late stages of the disease Gain of function mutation, resulting in an abnormal[emedicine.medscape.com] Initial examination disclosed a central type of positional nystagmus (conjugate downbeat nystagmus that did not fatigue with repeated positioning).[jnnp.bmj.com] The result is a lack of coordination and balance, or disturbance in their gait.[disabled-world.com]

  • Cerebellar Ataxia with Peripheral Neuropathy Type 2

    Gait ataxia, dysarthria, dysmetria, nystagmus, peripheral neuropathy, muscle wasting, and dystonia in late stages of the disease Gain of function mutation, resulting in an abnormal[emedicine.medscape.com] . ; EA2 with interictal nystagmus , is long-lasting (hours) associated with attacks of vertigo, diffuse weakness, slurred speech, dystonia, seizures, truncal and limb ataxia[neuroweb.us] Cortical Ataxias  FRONTAL LOBE ATAXIA refers to disturbed coordination due to dysfunction of the contralateral frontal lobe; -Results from disease involving the frontopontocerebellar[slideshare.net]

  • Spinocerebellar Ataxia with Rigidity and Peripheral Neuropathy

    Unsteady gait Oculomotor apraxia Focal seizures with impairment of consciousness or awareness Delayed gross motor development Agenesis of cerebellar vermis Abnormal saccadic[mendelian.co] . ; EA2 with interictal nystagmus , is long-lasting (hours) associated with attacks of vertigo, diffuse weakness, slurred speech, dystonia, seizures, truncal and limb ataxia[neuroweb.us] Cortical Ataxias  FRONTAL LOBE ATAXIA refers to disturbed coordination due to dysfunction of the contralateral frontal lobe  Results from disease involving the frontopontocerebellar[slideshare.net]

  • Cognitive Impairment with or without Cerebellar Ataxia

    […] of rapid alternating movements, such as tapping one hand with the palm and dorsum of the other hand Eye Movement Abnormalities Ocular Dysmetria Saccades overshoot or undershoot[brainaacn.org] . ; EA2 with interictal nystagmus , is long-lasting (hours) associated with attacks of vertigo, diffuse weakness, slurred speech, dystonia, seizures, truncal and limb ataxia[neuroweb.us] Ataxia is characterized by disturbances in the voluntary coordination of posture and movement.[healio.com]

  • Early-Onset Spastic Ataxia - Neuropathy Syndrome

    Also, from a clinical standpoint, the pontine nuclei have an important role in ocular pursuit and formation of saccades, and these major abnormalities are seen very early[ajnr.org] . ; EA2 with interictal nystagmus , is long-lasting (hours) associated with attacks of vertigo, diffuse weakness, slurred speech, dystonia, seizures, truncal and limb ataxia[neuroweb.us] Cardinal features - Cerebellar pathology – Stance and gait – Poor regulation and coordination of skilled movements (Dysmetria and dysdiadokinesia) – Eye movement disturbances[slideshare.net]

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