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424 Possible Causes for Abnormal Saccades, Interictal Downbeat Nystagmus, Sensory Neuropathy (Less Prominent Feature)

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  • Spinocerebellar Ataxia Type 6

    CONCLUSIONS: Among the earliest functional deficits in SCA6 are eye movement abnormalities, including impaired saccade velocity, saccade metrics, and pursuit gain.[ncbi.nlm.nih.gov] Initial examination disclosed a central type of positional nystagmus (conjugate downbeat nystagmus that did not fatigue with repeated positioning).[jnnp.bmj.com] […] vertical in 2 and horizontal in 3), saccade abnormalities in 3, and diplopia in 2.[doi.org]

  • Autosomal Recessive Spinocerebellar Ataxia 8

    […] in ocular saccades attention defects impaired verbal working memory and visuospatial skills Normal life expectancy Autosomal recessive ataxias are generally associated with[en.wikipedia.org] According to Baloh and others (1997), EA2 is characterized by a progressive ataxia with interictal rebound nystagmus evoked by gaze, as well as downbeating nystagmus.[tchain.com] Other clinical manifestations that might help with diagnosis and management Abnormal eye movements, e.g., slow saccades, various forms of nystagmus, can be helpful.[clinicaladvisor.com]

    Missing: Sensory Neuropathy (Less Prominent Feature)
  • Infantile Neuroaxonal Dystrophy 1

    INAD (Infantile Neuroaxonal Dystrophy) is a rare heredo-degenerative disease with onset in early infancy (after a period of latency), clinically characterized by progressive impairment of peripheral motor neurons and mental deterioration with cerebral and pyramidal signs and optic nerve atrophy. The authors[…][moh-it.pure.elsevier.com]

    Missing: Interictal Downbeat Nystagmus Sensory Neuropathy (Less Prominent Feature)
  • Spastic Ataxia with Congenital Miosis

    saccade the OKN is abnormal 25. a.F b.F c.F d.F e.T Aberrant regeneration of the third nerve (oculomotor synkinesis): features of congenital third nerve palsies and those[mrcophth.com] Interictal examination showed spontaneous downbeat and gaze-evoked nystagmus and mild dysarthria and truncal ataxia.[findzebra.com] Each patient also had abnormal eye movements with convergent squint, hypometric saccades, jerky pursuit movements, and nystagmus.[findzebra.com]

    Missing: Sensory Neuropathy (Less Prominent Feature)
  • Early-Onset Cerebellar Ataxia

    Apart from cerebellar signs and brisk knee jerks in all, other important findings were abnormal ocular movements (mostly impaired saccades) in 92.8%, Babinski's sign (78.6%[ncbi.nlm.nih.gov] . ; EA2 with interictal nystagmus , is long-lasting (hours) associated with attacks of vertigo, diffuse weakness, slurred speech, dystonia, seizures, truncal and limb ataxia[neuroweb.us] Abnormalities of saccades and optokinetic nystagmus were almost a constant feature in our patients and correlated well with the severe degree of atrophy of pons, the part[neurologyindia.com]

    Missing: Sensory Neuropathy (Less Prominent Feature)
  • Adult-Onset Autosomal Recessive Cerebellar Ataxia

    […] in ocular saccades attention defects impaired verbal working memory and visuospatial skills Normal life expectancy Autosomal recessive ataxias are generally associated with[en.wikipedia.org] . ; EA2 with interictal nystagmus , is long-lasting (hours) associated with attacks of vertigo, diffuse weakness, slurred speech, dystonia, seizures, truncal and limb ataxia[neuroweb.us] Clinical Characteristics Ocular Features: Nystagmus and saccadic pursuit eye movements are common signs. Some patients complain of diplopia.[disorders.eyes.arizona.edu]

    Missing: Sensory Neuropathy (Less Prominent Feature)
  • Episodic Ataxia

    It is characterized by episodic ataxia (of course), rebound nystagmus, saccadic overshoot dysmetria, abnormal pursuit and optokinetic nystagmus, and normal semicircular canal[dizziness-and-balance.com] Gait ataxia, dysarthria, dysmetria, nystagmus, peripheral neuropathy, muscle wasting, and dystonia in late stages of the disease Gain of function mutation, resulting in an abnormal[emedicine.com] Initial examination disclosed a central type of positional nystagmus (conjugate downbeat nystagmus that did not fatigue with repeated positioning).[jnnp.bmj.com]

    Missing: Sensory Neuropathy (Less Prominent Feature)
  • Spinocerebellar Ataxia Type 4

    Gait ataxia, dysarthria, dysmetria, nystagmus, peripheral neuropathy, muscle wasting, and dystonia in late stages of the disease Gain of function mutation, resulting in an abnormal[emedicine.medscape.com] Initial examination disclosed a central type of positional nystagmus (conjugate downbeat nystagmus that did not fatigue with repeated positioning).[jnnp.bmj.com] Abnormalities in eating habits, changes in amplitude and speed of saccades, nystagmus and commitment VOR are all more common in certain types of SCA [ 48 ].[tinnitusjournal.com]

    Missing: Sensory Neuropathy (Less Prominent Feature)
  • Cerebellar Ataxia with Peripheral Neuropathy Type 2

    Gait ataxia, dysarthria, dysmetria, nystagmus, peripheral neuropathy, muscle wasting, and dystonia in late stages of the disease Gain of function mutation, resulting in an abnormal[emedicine.medscape.com] . ; EA2 with interictal nystagmus , is long-lasting (hours) associated with attacks of vertigo, diffuse weakness, slurred speech, dystonia, seizures, truncal and limb ataxia[neuroweb.us] Saccades are dysmetric but saccadic velocities are normal. 18 Electroencephalography (EEG) reveals abnormalities in 40-60% of patients although frank epilepsy is much less[acnr.co.uk]

    Missing: Sensory Neuropathy (Less Prominent Feature)
  • Chronic Alcoholism

    […] in smooth pursuit eye movements, in saccadic inhibition during antisaccade tasks, and in prepulse inhibition, suggesting disturbed attention modulation and abnormal patterns[ncbi.nlm.nih.gov] RESULTS: Alcoholic patients display: (1) high beta and theta power in the resting electroencephalogram, suggesting hyperarousal of their central nervous system; (2) abnormalities[ncbi.nlm.nih.gov]

    Missing: Interictal Downbeat Nystagmus Sensory Neuropathy (Less Prominent Feature)

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