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832 Possible Causes for Abnormal Smooth Pursuit, Disturbance of Coordination, Interictal Downbeat Nystagmus

  • Autosomal Recessive Spinocerebellar Ataxia 8

    smooth pursuit [ Dupré et al 2007 ].[ncbi.nlm.nih.gov] According to Baloh and others (1997), EA2 is characterized by a progressive ataxia with interictal rebound nystagmus evoked by gaze, as well as downbeating nystagmus.[tchain.com] The result is a lack of coordination and balance, or disturbance in their gait.[disabled-world.com]

  • Episodic Ataxia

    smooth pursuit EA5 613855 AD CACNB4 (2q22-23) P/Q type calcium channel 20 Hours Vertigo, dysarthria Nystagmus, ataxia β4 subunit EA6 612656 AD or sporadic SLC1A3 (5p13.2)[e-jmd.org] According to Baloh and others (1997), EA2 is characterized by a progressive ataxia with interictal rebound nystagmus evoked by gaze, as well as downbeating nystagmus.[dizziness-and-balance.com] Ataxia is characterized by disturbances in the voluntary coordination of posture and movement.[healio.com]

  • Spinocerebellar Ataxia Type 26

    Signs and symptoms progress slowly, though eventually all affected persons have ataxia, upper limb in coordination, intention tremor, and dysarthria.[omicsonline.org] Visual disturbances and eye movement disorders including horizontal or vertical gaze nystagmus and diplopia develop in the majority of individuals with SCA6, in contradistinction[omicsonline.org]

    Missing: Interictal Downbeat Nystagmus
  • Autosomal Recessive Spastic Paraplegia Type 18

    (epilepsy), muscle atrophy, disturbance of the nerves in the arms and legs (neuropathy), and disturbance cognitive ability (intellectual impairment and dementia).[rarediseases.org] Other genetic types of HSP tend to be associated with additional symptoms (“complicated HSP”) including difficulty with coordination (“ataxia”), impaired vision, seizures[rarediseases.org] Previously, it was considered that HSP caused symptoms only in the legs, and therefore, did not affect the strength or coordination of the arms and hands, or speech or swallowing[rarediseases.org]

    Missing: Interictal Downbeat Nystagmus
  • Alpha-Mannosidosis

    Only the mutation H72L is in the active site itself, where it affects a metal-coordinating residue.[esrf.eu] Two others (T355P and P356R) are located at the start of an -helix in the active-site domain and presumably disturb the initiation of the helix and folding of the domain.[esrf.eu]

    Missing: Interictal Downbeat Nystagmus
  • Spinocerebellar Ataxia Type 6

    Eye movement abnormalities such as gaze evoked and downbeat nystagmus, impaired smooth pursuit and abnormal vestibulo-ocular reflex are commonly seen in SCA6 patients.[orpha.net] Initial examination disclosed a central type of positional nystagmus (conjugate downbeat nystagmus that did not fatigue with repeated positioning).[jnnp.bmj.com] The result is a lack of coordination and balance, or disturbance in their gait.[disabled-world.com]

  • Alcoholic Cerebellar Degeneration

    pursuits, intention tremor, or speech abnormalities.[mdedge.com] . ; EA2 with interictal nystagmus , is long-lasting (hours) associated with attacks of vertigo, diffuse weakness, slurred speech, dystonia, seizures, truncal and limb ataxia[neuroweb.us] […] ataxia of gait, and truncal instability, with generally preserved coordination of the upper extremities.[ncbi.nlm.nih.gov]

  • Adult-Onset Autosomal Recessive Cerebellar Ataxia

    Electronystagmography most commonly shows horizontal gaze-evoked nystagmus and impairment of smooth ocular pursuit.[acnr.co.uk] . ; EA2 with interictal nystagmus , is long-lasting (hours) associated with attacks of vertigo, diffuse weakness, slurred speech, dystonia, seizures, truncal and limb ataxia[neuroweb.us] The result is a lack of coordination and balance, or disturbance in their gait.[disabled-world.com]

  • Spinocerebellar Ataxia Type 4

    […] being responsible for smooth eye pursuit movement, the modulation and amplitude of saccades, and visual suppression of caloric induced nystagmus [ 18 ].[tinnitusjournal.com] Initial examination disclosed a central type of positional nystagmus (conjugate downbeat nystagmus that did not fatigue with repeated positioning).[jnnp.bmj.com] The result is a lack of coordination and balance, or disturbance in their gait.[disabled-world.com]

  • Cerebellar Ataxia with Peripheral Neuropathy Type 2

    Other features Ocular Motor Abnormalities: - usually if vestibular connections or flocculonodular lobe affected - pursuit movements no longer smooth, but saccadic - may over[slideshare.net] . ; EA2 with interictal nystagmus , is long-lasting (hours) associated with attacks of vertigo, diffuse weakness, slurred speech, dystonia, seizures, truncal and limb ataxia[neuroweb.us] Electronystagmography most commonly shows horizontal gaze-evoked nystagmus and impairment of smooth ocular pursuit.[acnr.co.uk]