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375 Possible Causes for Abnormal Smooth Pursuit, Dysdiadochokinesis, Mutation in the WWOX Gene

  • Autosomal Recessive Spinocerebellar Ataxia 8

    Mutation in the WWOX gene, D. schematic of the WWOX gene). Figure adapted from WWOX.[epilepsygenetics.net] smooth pursuit [ Dupré et al 2007 ].[ncbi.nlm.nih.gov] […] hemisphere) Neocerebellum Connected with Pons and cortex through thalalmus Planning and initiation of movements Regulation of fine limb movements Limb ataxia: Dysmetria, Dysdiadochokinesis[slideshare.net]

  • Spinocerebellar Ataxia Type 12

    Mutation in the WWOX gene, D. schematic of the WWOX gene). Figure adapted from WWOX.[epilepsygenetics.net] MalaCards based summary : Spinocerebellar Ataxia 12, also known as sca12, is related to spinocerebellar ataxia 36 and aceruloplasminemia, and has symptoms including dysdiadochokinesis[malacards.org] […] size of the outer layer of the brain due to loss of brain cells 0002120 Delusions 0000746 Depressivity Depression 0000716 Dysarthria Difficulty articulating speech 0001260 Dysdiadochokinesis[rarediseases.info.nih.gov]

    Missing: Abnormal Smooth Pursuit
  • Spinocerebellar Ataxia Type 26

    […] spinocerebellar ataxia type 18, is related to autosomal dominant cerebellar ataxia and spinocerebellar ataxia, autosomal recessive 18, and has symptoms including tremor and dysdiadochokinesis[malacards.org] Cerebellar signs (such as intention tremor, past pointing in the finger nose test, dysdiadochokinesis and truncal ataxia) were positive.[ancientscienceoflife.org]

    Missing: Mutation in the WWOX Gene
  • Autosomal Recessive Spastic Paraplegia Type 18

    The patient developed dysdiadochokinesis, but no cerebellar ocular signs were noted.[omicsonline.org]

    Missing: Mutation in the WWOX Gene
  • Lateral Medullary Syndrome

    These abnormalities include signs of dysfunction of ocular alignment (skew deviation, ocular tilt reaction, and environmental tilt), various types of nystagmus, smooth pursuit[ncbi.nlm.nih.gov] Axial FLAIR MRI of this patient, showing the hyperintensity in the right lateral medulla Abnormalities of ocular tracking eye movements (e.g. smooth pursuit and VOR cancellation[neuroophthalmology.ca] Reduced vertical VOR, smooth pursuit and VOR-cancellation have been described (754,758).[web.archive.org]

    Missing: Mutation in the WWOX Gene
  • Ataxia

    The tumour suppressor gene WWOX is mutated in autosomal recessive cerebellar ataxia with epilepsy and mental retardation.[ncbi.nlm.nih.gov] pursuits, intention tremor, or speech abnormalities.[mdedge.com] Nystagmus; Vestibulo-ocular reflex (VOR) Postural and gait dysfunction Midline (Vermis; paleocerebellum)Truncal & gait ataxia Hemisphere (Neocerebellum)Limb ataxia: Dysmetria, Dysdiadochokinesis[neuromuscular.wustl.edu]

  • Friedreich Ataxia

    They are usually horizontal and can be observed in primary position and during smooth pursuit.[doi.org] Square wave jerks (SWJ) represent a typical, though not pathognomonic eye movement abnormality of FA.[doi.org]

    Missing: Mutation in the WWOX Gene
  • Autosomal Recessive Spastic Ataxia with Leukoencephalopathy

    Koenig, The tumour suppressor gene WWOX is mutated in autosomal recessive cerebellar ataxia with epilepsy and mental retardation. Brain, 2014. 137(Pt 2): p. 411-9.[hih-tuebingen.de] […] ocular smooth pursuit Jerky ocular pursuit movements Abnormal head movements Jerky head movements Simultanapraxia Generalized hyperpigmentation Optic atrophy Aspiration Recurrent[mendelian.co] The tumour suppressor gene WWOX is mutated in autosomal recessive cerebellar ataxia with epilepsy and mental retardation. Brain. 2014;137:411–9.[link.springer.com]

  • Spastic Ataxia with Congenital Miosis

    […] nystagmus, and impaired smooth pursuit.[findzebra.com] 33 HP:0002075 12 abnormal conjugate eye movement 33 HP:0000549 Symptoms via clinical synopsis from OMIM: 58 Neurologic Central Nervous System: dysdiadochokinesis delayed[malacards.org] Physical examination showed gait ataxia and dysmetria and dysdiadochokinesis of the limbs.[findzebra.com]

    Missing: Mutation in the WWOX Gene
  • Autosomal Recessive Spinocerebellar Ataxia

    WWOX is mutated in autosomal recessive cerebellar ataxia with epilepsy and mental retardation.[genome.jp] Electronystagmography most commonly shows horizontal gaze-evoked nystagmus and impairment of smooth ocular pursuit.[acnr.co.uk] 29 See the list below: Clinical features Nonprogressive ataxia Nystagmus Dysarthria Psychomotor display Clumsiness Cognitive impairment Frequent falling early in disease Dysdiadochokinesis[emedicine.medscape.com]