Absence of Subcutaneous Fat: Causes & Reasons

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Possible Causes for Absence of Subcutaneous Fat

Familial Partial Lipodystrophy

Absence of subcutaneous fat from the upper and lower extremities during childhood or puberty. [manbironline.com]

Thin wrinkles of skin under the buttocks confirm the absence of subcutaneous fat. [doi.org]

In this Loss of fat is limited to the extremities with normal amounts of fat in the face and normal or even excess fat in the truncal area. [manbironline.com]

Lipodystrophy

[…] lipodystrophy [ lip″o-dis´tro-fe ] 1. any disturbance of fat metabolism. 2. a group of conditions due to defective metabolism of fat, resulting in absence of subcutaneous [medical-dictionary.thefreedictionary.com]

[…] of subcutaneous fat. [care.diabetesjournals.org]

(See Atlas 2, Part F.) congenital generalized lipodystrophy an autosomal recessive condition marked by the virtual absence of subcutaneous adipose tissue, large body size, [medical-dictionary.thefreedictionary.com]

Acquired Generalized Lipodystrophy

[…] of subcutaneous fat and the presence of muscle hypertrophy, hyperlipemia, diabetes mellitus, and hepatosplenomegaly with cirrhosis. [epathologies.com]

[…] of subcutaneous fat, muscular hypertrophy, generalized hypertrichosis, and progressively increasing abdominal size, since 4 months of her age. [ijpd.in]

[…] of subcutaneous fat (Figure 1) [ 2 ]. [omicsonline.org]

Congenital Generalized Lipodystrophy

[…] of subcutaneous fat. [8] CGL3 patients have serum creatine kinase concentrations much higher than normal (2.5 to 10 times the normal limit). [en.wikipedia.org]

[…] of subcutaneous fat, muscular hypertrophy, generalized hypertrichosis, and progressively increasing abdominal size, since 4 months of her age. [ijpd.in]

Biopsy of the skin showed an absence of subcutaneous fat. Hyper-insulinaemia was noted 148.2 IU/ml (normal 3-35 IU/ml). [jpma.org.pk]

Progeria

She died 7 hours after birth and presented with intrauterine growth retardation, premature aging, absence of subcutaneous fat, brachydactyly, absent nipples, hypoplastic external [ncbi.nlm.nih.gov]

It is clinically characterised by postnatal growth retardation, midface hypoplasia, micrognathia, premature atherosclerosis, absence of subcutaneous fat, alopecia and generalised [eurasnet.info]

[…] of subcutaneous fat Absent fat below the skin Lack of fatty tissue below the skin [ more ] 0007485 Autosomal dominant inheritance 0000006 Autosomal recessive inheritance [rarediseases.info.nih.gov]

Acquired Partial Lipodystrophy

[…] of subcutaneous fat (Figure 1) [ 2 ]. [omicsonline.org]

[…] of adipose tissue in the upper part of the body,' and then as segmental atrophy of the subcutaneous fat layer by Barraquer [8] in 1907, and as 'lipodystrofia progressiva' [arthritisresearch.us]

The abnormal fat repartition was in conformity with the essential criterion proposed by Misra et al. [12]: with gradual symmetrical subcutaneous fat loss from the face, neck [ncbi.nlm.nih.gov]

Lipoatrophic Diabetes Mellitus

The entire clinical syndrome of lipoatrophic diabetes as first described by Lawrence (6) encompasses: (1) generalized lipodystrophy (complete absence of subcutaneous, intra-abdominal [journals.lww.com]

Therefore, novel CGL genes may be identified in the future. 23 The most striking clinical manifestations of CGL are abnormal appearance due to the absence of subcutaneous [dovepress.com]

and perinephric fat); (2) hepatosplenomegaly; (3) insulin-resistant diabetes with little tendency to develop ketosis; (4) hyperlipidemia; and (5) a marked elevation of basal [journals.lww.com]

Werner Syndrome

Werner Syndrome is a rare genetic disorder associated with premature aging. Symptoms generally manifest during the third decade of life and consist of several pathologies, typically observed in much older people. Severe atherosclerosis and cancer are two of these symptoms and the most common causes of death. WS[…] [symptoma.com]

Congenital Generalized Lipodystrophy Type 4

Generalized lipodystrophy syndrome is the association of acanthosis nigricans (AN) with the generalized complete absence of subcutaneous fat and the presence of muscle hypertrophy [emedicine.medscape.com]

[…] of subcutaneous fat.[8] CGL3 patients have serum creatine kinase concentrations much higher than normal (2.5 to 10 times the normal limit). [en.wikipedia.org]

Transverse sections of the midthigh demonstrate an absence of subcutaneous fat, deep fat, intrafascicular fat, and marrow fat (bottom left); note light-colored, lipid-filled [emedicine.medscape.com]

Wiedemann-Rautenstrauch Syndrome

Mainly characterized by congenital absence of subcutaneous fat tissue, this child is very similar to four patients reported earlier and recognized as representing a newly [ncbi.nlm.nih.gov]

Abnormal findings included a generalized virtual absence of subcutaneous fat, sparse scalp hair, prominence of veins and muscles, a large and persistent anterior fontanelle [lib.ugent.be]

Congenital Generalized Lipodystrophy Type 1

[…] of subcutaneous fat.[8] CGL3 patients have serum creatine kinase concentrations much higher than normal (2.5 to 10 times the normal limit). [en.wikipedia.org]

[…] of subcutaneous fat, muscular hypertrophy, generalized hypertrichosis, and progressively increasing abdominal size, since 4 months of her age. [ijpd.in]

Congenital Generalized Lipodystrophy Type 2

[…] of subcutaneous fat.[8] CGL3 patients have serum creatine kinase concentrations much higher than normal (2.5 to 10 times the normal limit). [en.wikipedia.org]

[…] of subcutaneous fat, muscular hypertrophy, generalized hypertrichosis, and progressively increasing abdominal size, since 4 months of her age. [ijpd.in]

Setleis Syndrome

Histologically, the bitemporal lesion is an ectodermal dysplasia with near absence of subcutaneous fat, suggesting insufficient migration of neural crest cells into the frontonasal [uniprot.org]

[…] of subcutaneous fat, suggesting insufficient migration of neural crest cells into the frontonasal process and the first branchial arch), and typical facies including a coarse [medical-dictionary.thefreedictionary.com]

[…] focal facial dermal dysplasia with distinctive bitemporal scar-like depressions resembling forceps marks (which histologically corresponds to ectodermal dysplasia with near absence [medical-dictionary.thefreedictionary.com]

Progeroid Facial Appearance with Hand Anomalies

Further on the patient showed the diagnostic criteria of Wiedemann-Rautenstrauch syndrome: Beside growth failure and nearly absence of subcutaneous fat, old-looking face with [ncbi.nlm.nih.gov]

Mainly characterized by congenital absence of subcutaneous fat tissue, this child is very similar to four patients reported earlier and recognized as representing a newly [link.springer.com]

Findings include generalized absence of subcutaneous fat, frontal bossing, sparse hair and eyebrows, promi- nent veins on scalp, flat face, shallow orbits, hyper- telorism [documents.tips]

Poland Syndrome

[…] of subcutaneous fat and axillary hair Absence of the sternal head of the pectoralis major muscle May also include absence of adjacent muscles such as pectoralis minor (common [learningradiology.com]

[…] be present, which include: Shortened ribs The absence of subcutaneous fat from under the skin, which make the ribs prominent and noticeable Breast and nipple abnormalities [dovemed.com]

[…] are rarely present in the same patient, but include Ipsilateral breast and nipple hypoplasia and/or aplasia Involved nipple is smaller and higher than normal Deficiency or absence [learningradiology.com]

Absence of Pectoralis Muscle

[…] be present, which include: Shortened ribs The absence of subcutaneous fat from under the skin, which make the ribs prominent and noticeable Breast and nipple abnormalities [dovemed.com]

fat and axillary hair, absence of the sternal head of the pectoralis major muscle, hypoplasia of the rib cage, and hypoplasia of the upper extremity. [emedicine.medscape.com]

Progeroid Syndrome Type Petty

The absence of subcutaneous fat and premature ageing are defining and serious features of the condition. [fdna.health]

[…] of subcutaneous fat Absent fat below the skin 0007485 Arnold-Chiari malformation 0002308 Autosomal recessive inheritance 0000007 Congenital onset Symptoms present at birth [rarediseases.info.nih.gov]

[…] diabetes Type II diabetes [ more ] 0005978 Percent of people who have these symptoms is not available through HPO Abnormality of cardiovascular system morphology 0030680 Absence [rarediseases.info.nih.gov]

Unilateral Hypoplasia or Absence of Pectoralis Major Muscle

Among these, the most frequent are costal aplasias/hypoplasias, depressions of the chest wall, atelia or amastia, absence of axillary hair, hypoplasia of subcutaneous fat, [thoracicmedicine.org]

fat and axillary hair, absence of the sternal head of the pectoralis major muscle, hypoplasia of the rib cage, and hypoplasia of the upper extremity. [emedicine.medscape.com]

Autosomal Recessive Ichthyosis with Hypotrichosis ARCI11

[…] of subcutaneous fat Premature coronary artery atherosclerosis Thin nail Widely patent fontanelles and sutures Decreased testosterone in males Carcinoid tumor Aplastic clavicle [mendelian.co]

[…] sicca Thin ribs Renal cell carcinoma Thin bony cortex Prolonged prothrombin time Insulin-resistant diabetes mellitus at puberty Bird-like facies Craniofacial disproportion Absence [mendelian.co]

[…] development Bilateral coxa valga Reticulated skin pigmentation Hypoplastic facial bones Sinus tachycardia Mitral valve calcification Intermittent claudication Abnormal EKG Absence [mendelian.co]

Congenital Malformation of the Ribs

Absence of the right breast. 2. Absence of subcutaneous fat over the right hemithorax. 3. Absence of the pectoralis muscles, as per history given. 4. [mdmag.com]

[…] of a pronounced muscular and subcutaneous fat layer on the concave side of the thorax, which created technical difficulties in covering the metal implant. [journals.eco-vector.com]

[…] and the progressive nature of the curvature along with the continued growth of the child; the second group of complications was due to patient’s hypotrophy, as well as the absence [journals.eco-vector.com]

Partial Acquired Lipodystrophy Associated with C3 Nephritic Factor

Loss of adipose tissue is not preceded by an inflammatory phase, and histopathologic examination reveals only absence of subcutaneous fat. [easypediatrics.com]

On examination, her BMI was 23.7kg/m 2 and there was an absence of subcutaneous fat on her limbs and trunk, and reduced breast tissue. [practicaldiabetes.com]

Magnetic resonance (MR) imaging of the abdomen shows complete absence of intraabdominal, retroperitoneal, and subcutaneous fat but a prominent fatty liver and presence of [clinicalgate.com]

Congenital Generalized Hypertrichosis

Biopsy of the skin showed an absence of subcutaneous fat. Hyper-insulinaemia was noted 148.2 IU/ml (normal 3-35 IU/ml). [jpma.org.pk]

[…] of subcutaneous fat, muscular hypertrophy, generalized hypertrichosis, and progressively increasing abdominal size, since 4 months of her age. [ijpd.in]

13-month-old female child, born out of nonconsanguineous marriage, was brought to our department with complaints of abnormal facial features, almost complete generalized absence [ijpd.in]

Spastic Paraparesis-Deafness Syndrome

Those affected appear muscular due to absence of subcutaneous fat, and have prominent jaws and orbital ridges together with large hands and feet. [diapedia.org]

The condition is characterized by hypertriglyceridaemia and ectopic deposition of fat in the liver, causing steatosis, and in the heart, causing cardiomyopathy. [diapedia.org]

Chromosome 16q22 Deletion Syndrome

[…] of subcutaneous fat Female pseudohermaphroditism Hyperparathyroidism Irregular vertebral endplates Progressive gait ataxia Memory impairment Abnormality of the musculature [mendelian.co]

Abnormality of the abdominal wall Motor tics Myopia Feeding difficulties Asymmetry of the breasts Prominent nipples Adipose tissue loss Elfin facies Postprandial hyperglycemia Absence [mendelian.co]

Rhizomelic Syndrome Type Urbach

[…] of subcutaneous fat, muscular appearing arms/legs, acanthosis nigricans, DM Focal dermal hypoplasia (Goltz syndrome) XLD; POCRN (X chromosome encodes acyltransferase); alopecia [quizlet.com]

[…] marenostrin); recurrent febrile episodes with self-limited but painful episodes of synovitis, peritonitis, pleuritis Familial partial lipodystrophy AD; LMNA (laminins A + C); absence [quizlet.com]

Bardet-Biedl Syndrome Type 11

Those affected appear muscular due to absence of subcutaneous fat, and have prominent jaws and orbital ridges together with large hands and feet. [diapedia.org]

The condition is characterized by hypertriglyceridaemia and ectopic deposition of fat in the liver, causing steatosis, and in the heart, causing cardiomyopathy. [diapedia.org]

Deafness - Hypogonadism Syndrome

Those affected appear muscular due to absence of subcutaneous fat, and have prominent jaws and orbital ridges together with large hands and feet. [diapedia.org]

The condition is characterized by hypertriglyceridaemia and ectopic deposition of fat in the liver, causing steatosis, and in the heart, causing cardiomyopathy. [diapedia.org]

Bilateral Sensorineural Hearing Loss

[…] of subcutaneous fat Absence of pubertal development Bilateral coxa valga Reticulated skin pigmentation Hypoplastic facial bones Sinus tachycardia Mitral valve calcification [mendelian.co]

[…] flexion contracture Macule Osteoma Glioma Increased circulating cortisol level Palmoplantar hyperhidrosis Persistence of primary teeth Aplasia/Hypoplasia of the earlobes Absence [mendelian.co]

Mandibular Hypoplasia - Deafness - Progeroid Syndrome

[…] of subcutaneous fat Absent fat below the skin 0007485 Autosomal recessive inheritance 0000007 Congenital onset Symptoms present at birth 0003577 Delayed closure of the anterior [rarediseases.info.nih.gov]

Donohue Syndrome

An absence of subcutaneous body fat, hirsutism, and dysplastic nails may also be seen. [symptoma.com]

[…] of subcutaneous fat, wrinkled and loose skin, hirsutism, acanthosis nigricans, disproportionately large genitalia with bilateral inguinal hernia, and a protuberant abdomen [hmg.oxfordjournals.org]

[…] birth, the infant was noted to have dysmorphic features, such as a small face with prominent eyes and thick lips, large, pointed ears, depressed nasal bridge, wide nostrils, absence [hmg.oxfordjournals.org]