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22 Possible Causes for Absent Knee Reflex, Asthenia, Spasticity - Hyperreflexia

  • Hyponatremia

    They are primarily central nervous system (CNS) manifestations, such as irritability, restlessness, lethargy, muscular twitching, spasticity and hyperreflexia, all of which[aafp.org] CASE: A 17-year-old boy was admitted to the emergency department with abdominal pain, nausea and vomiting, asthenia, and weight loss.[ncbi.nlm.nih.gov]

  • Motor Neuron Disease

    Lower motor neuron (LMN) findings include muscle atrophy and fasciculations, and upper motor neuron (UMN) findings include hyperreflexia, spasticity, muscle spasm, and abnormal[en.wikipedia.org] , hyperreflexia and atrophy in later stages of disease, but fasciculations are absent.[symptoma.com] The essential clinical findings are slowly progressive and often include severe spasticity, hyperreflexia, and weakness in a pyramidal distribution, noticeably in both lower[emedicine.medscape.com]

  • Lumbosacral Plexus Disorder

    There is an absent or reduced knee jerk reflex, although ankle jerks are commonly preserved.[patient.info] The disorder affects men exclusively and is characterized by muscle wasting and weakness, without signs of upper motor neuron dysfunction such as spasticity or hyperreflexia[neupsykey.com] […] amitriptyline but less sedating Desipramine 10-300 mg Similar to amitriptyline but least sedating Duloxetine 60-120 mg Nausea, dry mouth, constipation Venlafaxine XR 37.5-225 mg Asthenia[clevelandclinicmeded.com]

  • Friedreich Ataxia

    Most people with FA also have reduced or absent leg reflexes, such as the knee-jerk reflex. In a small fraction of people, FA leads to hearing loss or visual impairment.[web.archive.org] His examination was significant for spastic gait, hyperreflexia, and sensory neuropathy. Genetic testing revealed a compound heterozygous mutation in the FXN gene.[ncbi.nlm.nih.gov] Adverse effects One participant in Zannolli 2012 (total of 13 enrolled participants) experienced asthenia during drug tapering, which did not require medical intervention.[doi.org]

  • Lower Motor Neuron Syndrome with Late-Adult Onset

    Subsequently, usually after age 50 years, proximal and distal weakness progressed slowly, over decades, in the absence of manifest atrophy, with absent deep tendon reflexes[ahcmedia.com] , spasticity -muscle atrophy (fasciculations), fasciculations, tongue atrophy, rapidly progressive (lethal) -upper & lower motor neurons, bulbar weakness -normal sensation[brainscape.com] Approximately 10% of patients stop the drug because of adverse events, principally gastrointestinal intolerance and asthenia.[neuroweb.us]

  • Mononeuritis

    […] ankle reflexes, indifferent plantar reflexes, reduced positional sense in left ankle and up to right knee and reduced vibration and superficial pain sense up to both knees[bmcneurol.biomedcentral.com] CNS Upper motor neuron signs (spasticity, hyperreflexia, upgoing plantar reflexes) are usually seen distal to the lesion.[clinicaladvisor.com] […] amitriptyline but less sedating Desipramine 10-300 mg Similar to amitriptyline but least sedating Duloxetine 60-120 mg Nausea, dry mouth, constipation Venlafaxine XR 37.5-225 mg Asthenia[clevelandclinicmeded.com]

  • Mononeuritis Multiplex

    […] ankle reflexes, indifferent plantar reflexes, reduced positional sense in left ankle and up to right knee and reduced vibration and superficial pain sense up to both knees[ncbi.nlm.nih.gov] CNS Upper motor neuron signs (spasticity, hyperreflexia, upgoing plantar reflexes) are usually seen distal to the lesion.[cancertherapyadvisor.com] […] amitriptyline but less sedating Desipramine 10-300 mg Similar to amitriptyline but least sedating Duloxetine 60-120 mg Nausea, dry mouth, constipation Venlafaxine XR 37.5-225 mg Asthenia[clevelandclinicmeded.com]

  • Distal Myopathy Type 3

    Knee reflexes were absent, while all other tendon reflexes were normal. In both individuals, distal upper limb muscles showed normal strength.[bmcmedgenet.biomedcentral.com] Hyperreflexia Babinski's N/A Both upper and lower motor neuron signs Clinical diagnosis Normal Nonspecific findings of chronic denervation with reinnervation Neuropathic[wikidoc.org] Asthenia is a sense of weariness or exhaustion in the absence of muscle weakness.[aafp.org]

  • Ataxia

    reflexes, and dysarthria is minimal or absent. 73 74 76 Comparing the clinical parameters of those with point mutations to those homozygous for a GAA expansion, Cossee et[jmg.bmj.com] Typical clinical signs and symptoms of autosomal dominant ataxias (ADCA) include the following: Limb and truncal ataxia Hyperreflexia and spasticity (pyramidal signs) are[centogene.com] This results in a characteristic type of irregular, uncoordinated movement that can manifest itself in many possible ways, such as asthenia, asynergy, delayed reaction time[en.wikipedia.org]

  • Adult-Onset Autosomal Recessive Cerebellar Ataxia

    […] are frequently increased, but by adulthood, may diminish or become absent due to progressive neuropathy.[acnr.co.uk] , and spasticity; mental retardation, cognitive impairment, or both; and epilepsy.[blogs.nejm.org] (appendicular or axial)  Dysmetria  Dyssynergia  Dysdiadochokinesia  Rebound Phenomenon  Dysarthria  Tremor  Titubation and increased postural sway  Hypotonia  Asthenia[slideshare.net]

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