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22 Possible Causes for Absent Knee Reflex, Insulin Increased, Numbness of the Feet

  • Diabetes Mellitus

    Of 19,075 occupation-eligible working adults included in the analysis, 1003 reported a physician diagnosis of diabetes; 38% of these reported numbness or tingling in feet[ncbi.nlm.nih.gov] […] frequency of insulin-dependent diabetes in several countries is best explained today by the decline of infections.[dx.doi.org] The nerves to the legs are damaged first, causing pain and numbness in the feet. This can advance to cause symptoms in the legs and hands.[drugs.com]

  • Hyperkalemia

    Meanwhile, in respiratory acidosis, the effect on serum potassium level is small through an unknown mechanism.The hormone insulin increases the uptake of potassium into the[en.wikipedia.org] Patients with moderate or severe hyperkalemia may also develop nervous symptoms such as tingling of the skin, numbness of the hands or feet, weakness, or a flaccid paralysis[medical-dictionary.thefreedictionary.com] Because the risk of hypoglycemia is increased with using large insulin doses, sufficient glucose (60 grams with the administration of 20 units of insulin and 50 grams with[ncbi.nlm.nih.gov]

  • Diabetic Polyneuropathy

    Ankle reflexes are usually reduced or absent, and knee reflexes may also be reduced in some cases.[clinical.diabetesjournals.org] Muscle biopsy showed scattered regenerating fibers, small angular fibers and increased PAS positive particles.[ncbi.nlm.nih.gov] The primary outcome measure was the change from baseline of the Total Symptom Score (TSS), including stabbing pain, burning pain, paresthesia, and asleep numbness of the feet[drperlmutter.com]

  • Diabetic Peripheral Neuropathy

    Ankle reflexes are usually reduced or absent, and knee reflexes may also be reduced in some cases.[clinical.diabetesjournals.org] The development and progression of DPN is due in large part to hyperglycemia but is also affected by insulin deficiency and dyslipidemia.[pharmrev.aspetjournals.org] Burning, tingling, numbness to your feet?! Does this sound familiar? Are you a diabetic?[faant.com]

  • Diabetic Autonomic Neuropathy

    The treatment included behavioural therapy, encouragement to eat, increased insulin dosages, and therapy for painful neuropathy with paracetamol and amitriptyline.[pmj.bmj.com] […] in the feet and legs.[podiatrytoday.com] After the oral glucose load, GIP levels presented a significant increase in normal subjects and patients without AN, whereas GLP-1 levels increased only in normal subjects[ncbi.nlm.nih.gov]

  • Spinal Stenosis

    Lumbar spinal stenosis can cause pain in the low back or buttocks, abnormal sensations, and the absence of sensation (numbness) in the legs, thighs, feet, or buttocks, or[en.wikipedia.org] Due to the diversion of amino-acids to glucose, they are considered anti-anabolic, and long term therapy can cause muscle wasting. [19] Endocrine: By increasing the production[en.wikipedia.org] Burning, stabbing, a cold feeling, aching, numbness, paresthesia, or a weak or tired feeling of the feet (during some part of the disease process) depend on spinal position[ncbi.nlm.nih.gov]

  • Guillain-Barré Syndrome

    In GBS, deep tendon reflexes in the legs, such as knee jerks, are usually lost. Reflexes may also be absent in the arms.[ninds.nih.gov] There was no evidence of harm from corticosteroids except that increased blood glucose concentrations requiring insulin were significantly more common.[doi.org] The syndrome is "very, very variable" from person to person -- some may just experience numbness in the feet while others may suffer complete paralysis.[cbsnews.com]

  • Friedreich Ataxia

    Most people with FA also have reduced or absent leg reflexes, such as the knee-jerk reflex. In a small fraction of people, FA leads to hearing loss or visual impairment.[web.archive.org] […] paralysis of the lower limb impaired speech impaired swallowing spine may begin to curve to one side (scoliosis) feet may become rigid and deformed vision problems hearing[healthcentral.com] The effect of age to some degree may be mediated through changes in BMI, with increasing age associated with increases in BMI, and with HOMA-IR and insulin increases in children[ncbi.nlm.nih.gov]

  • Peripheral Neuropathy

    Ankle reflexes are usually reduced or absent, and knee reflexes may also be reduced in some cases.[clinical.diabetesjournals.org] Advanced glycation end products attenuate cellular insulin sensitivity by increasing the generation of intracellular reactive oxygen species in adipocytes.[doi.org] Numbness in the feet can lead to skin sores that do not heal. In rare cases, numbness in the feet may lead to amputation.[nlm.nih.gov]

  • Hypokalemic Periodic Paralysis

    During the paralytic episode, serum potassium levels were reduced, and serum chloride and insulin levels were increased.[ncbi.nlm.nih.gov] The most common side effects are a feeling of numbness, tingling or burning (“pins and needles”) in the toes, feet, hands or fingers; trouble with memory or thinking; feeling[keveyis.com] Increased sodium-potassium ATPase pump activity and enhanced insulin response in patients with TPP are postulated to contribute to the hypokalemia.[mjdrdypu.org]