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22 Possible Causes for Absent Knee Reflex, Insulin Increased, Numbness of the Feet

  • Diabetes Mellitus

    Of 19,075 occupation-eligible working adults included in the analysis, 1003 reported a physician diagnosis of diabetes; 38% of these reported numbness or tingling in feet[] […] frequency of insulin-dependent diabetes in several countries is best explained today by the decline of infections.[] The nerves to the legs are damaged first, causing pain and numbness in the feet. This can advance to cause symptoms in the legs and hands.[]

  • Hyperkalemia

    Meanwhile, in respiratory acidosis, the effect on serum potassium level is small through an unknown mechanism.The hormone insulin increases the uptake of potassium into the[] Patients with moderate or severe hyperkalemia may also develop nervous symptoms such as tingling of the skin, numbness of the hands or feet, weakness, or a flaccid paralysis[] Because the risk of hypoglycemia is increased with using large insulin doses, sufficient glucose (60 grams with the administration of 20 units of insulin and 50 grams with[]

  • Diabetic Polyneuropathy

    Ankle reflexes are usually reduced or absent, and knee reflexes may also be reduced in some cases.[] Muscle biopsy showed scattered regenerating fibers, small angular fibers and increased PAS positive particles.[] The primary outcome measure was the change from baseline of the Total Symptom Score (TSS), including stabbing pain, burning pain, paresthesia, and asleep numbness of the feet[]

  • Diabetic Peripheral Neuropathy

    Ankle reflexes are usually reduced or absent, and knee reflexes may also be reduced in some cases.[] The development and progression of DPN is due in large part to hyperglycemia but is also affected by insulin deficiency and dyslipidemia.[] Burning, tingling, numbness to your feet?! Does this sound familiar? Are you a diabetic?[]

  • Diabetic Autonomic Neuropathy

    The treatment included behavioural therapy, encouragement to eat, increased insulin dosages, and therapy for painful neuropathy with paracetamol and amitriptyline.[] […] in the feet and legs.[] After the oral glucose load, GIP levels presented a significant increase in normal subjects and patients without AN, whereas GLP-1 levels increased only in normal subjects[]

  • Spinal Stenosis

    Lumbar spinal stenosis can cause pain in the low back or buttocks, abnormal sensations, and the absence of sensation (numbness) in the legs, thighs, feet, or buttocks, or[] Due to the diversion of amino-acids to glucose, they are considered anti-anabolic, and long term therapy can cause muscle wasting. [19] Endocrine: By increasing the production[] Burning, stabbing, a cold feeling, aching, numbness, paresthesia, or a weak or tired feeling of the feet (during some part of the disease process) depend on spinal position[]

  • Guillain-Barré Syndrome

    In GBS, deep tendon reflexes in the legs, such as knee jerks, are usually lost. Reflexes may also be absent in the arms.[] There was no evidence of harm from corticosteroids except that increased blood glucose concentrations requiring insulin were significantly more common.[] The syndrome is "very, very variable" from person to person -- some may just experience numbness in the feet while others may suffer complete paralysis.[]

  • Friedreich Ataxia

    Most people with FA also have reduced or absent leg reflexes, such as the knee-jerk reflex. In a small fraction of people, FA leads to hearing loss or visual impairment.[] […] paralysis of the lower limb impaired speech impaired swallowing spine may begin to curve to one side (scoliosis) feet may become rigid and deformed vision problems hearing[] The effect of age to some degree may be mediated through changes in BMI, with increasing age associated with increases in BMI, and with HOMA-IR and insulin increases in children[]

  • Peripheral Neuropathy

    Ankle reflexes are usually reduced or absent, and knee reflexes may also be reduced in some cases.[] Advanced glycation end products attenuate cellular insulin sensitivity by increasing the generation of intracellular reactive oxygen species in adipocytes.[] Numbness in the feet can lead to skin sores that do not heal. In rare cases, numbness in the feet may lead to amputation.[]

  • Hypokalemic Periodic Paralysis

    During the paralytic episode, serum potassium levels were reduced, and serum chloride and insulin levels were increased.[] The most common side effects are a feeling of numbness, tingling or burning (“pins and needles”) in the toes, feet, hands or fingers; trouble with memory or thinking; feeling[] Increased sodium-potassium ATPase pump activity and enhanced insulin response in patients with TPP are postulated to contribute to the hypokalemia.[]