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120 Possible Causes for Absent Platelet Agglutination in Presence of Ristocetin, Congenital Bleeding Diathesis

  • Bernard-Soulier Syndrome

    agglutination and low or absent expression of the GPIb-V-IX complex.[ncbi.nlm.nih.gov] Diagnosis is based on a prolonged skin bleeding time, the presence of a small number of very large platelets (macrothrombocytopenia), defective ristocetin-induced platelet[ncbi.nlm.nih.gov]

  • Inherited Platelet Disorder

    […] aggregation with ADP, collagen, and epinephrine, but absent platelet agglutination in the presence of ristocetin.[ommbid.mhmedical.com] diathesis, with a true incidence still unknown.[ojrd.biomedcentral.com] Bernard-Soulier syndrome represents the second most recognized inherited platelet disorder, and is characterized by a prolonged bleeding time, giant platelets, normal platelet[ommbid.mhmedical.com]

  • Thrombocytopenia

    […] anomalies Varies depending on primary abnormality Often asymptomatic when there is no bleeding diathesis Disseminated intravascular coagulation Severe Acute illness; bleeding[aafp.org] They usually present in the paediatric age group with bleeding diathesis. Mild cases, however, may remain undiagnosed until older age.[racgp.org.au] […] to moderate Long history of abnormal platelet count or family history of thrombocytopenia Many disorders associated with giant platelets, neutrophil inclusions, or other congenital[aafp.org]

    Missing: Absent Platelet Agglutination in Presence of Ristocetin
  • Hemolytic Anemia

    […] acquired: DIC ( Congenital afibrinogenemia, Purpura fulminans ) - autoimmune ( Antiphospholipid ) Other Essential thrombocytosis - clotting factor: Hemophilia ( A/VIII, B[wikidoc.org] […] anemia, Sideroblastic anemia Blood tests Normocytic - Microcytic - Macrocytic - Normochromic - Hypochromic Other Methemoglobinemia Coagulation / platelets / coagulopathy / bleeding[wikidoc.org] diathesis Hypercoagulability primary: Antithrombin III deficiency - Protein C deficiency / Activated protein C resistance / Protein S deficiency / Factor V Leiden - Hyperprothrombinemia[wikidoc.org]

    Missing: Absent Platelet Agglutination in Presence of Ristocetin
  • Acute Interstitial Nephritis

    . • Oligohydramnios with congenital renal insufficiency may occur in inutero exposure of fetus to NSAIDs which may cause bleeding diathesis, premature closure of ductus arteriosus[slideshare.net]

    Missing: Absent Platelet Agglutination in Presence of Ristocetin
  • Bleeding Diathesis

    Congenital plasminogen activator inhibitor-1 (PAI-1) deficiency is an extremely rare disorder characterized by a bleeding diathesis that begins in childhood due to hyperfibrinolysis[ncbi.nlm.nih.gov] bleeding diathesis that begins in childhood due to hyperfibrinolysis as a result of decreased PAI-1 activity.[karger.com] ‘A lifelong bleeding diathesis may suggest a congenital platelet dysfunction, but an onset in adulthood does not necessarily exclude a congenital problem.’[en.oxforddictionaries.com]

    Missing: Absent Platelet Agglutination in Presence of Ristocetin
  • Pulmonary Hemangioma

    […] malformation Pulmonary sequestration Congenital pulmonary airway malformation (CPAM) Bronchogenic cyst Bleeding diathesis Thrombocytopenia Disseminated intravascular coagulation[oatext.com] Bronchiectasis (cystic fibrosis, primary cilliary dyskinesia) Tuberculosis Lung abscess Pneumonia (bacterial, fungal, viral, parasitic, mycoplasma, legionella) Bronchitis Congenital[oatext.com]

    Missing: Absent Platelet Agglutination in Presence of Ristocetin
  • Leukoerythroblastic Anemia

    […] acquired: DIC ( Congenital afibrinogenemia, Purpura fulminans ) - autoimmune ( Antiphospholipid ) Other Essential thrombocytosis - clotting factor: Hemophilia ( A/VIII, B[wikidoc.org] […] anemia, Sideroblastic anemia Blood tests Normocytic - Microcytic - Macrocytic - Normochromic - Hypochromic Other Methemoglobinemia Coagulation / platelets / coagulopathy / bleeding[wikidoc.org] diathesis Hypercoagulability primary: Antithrombin III deficiency - Protein C deficiency / Activated protein C resistance / Protein S deficiency / Factor V Leiden - Hyperprothrombinemia[wikidoc.org]

    Missing: Absent Platelet Agglutination in Presence of Ristocetin
  • Familial Neutropenia

    […] acquired: DIC ( Congenital afibrinogenemia, Purpura fulminans ) - autoimmune ( Antiphospholipid ) Other Essential thrombocytosis - clotting factor: Hemophilia ( A/VIII, B[wikidoc.org] […] anemia, Sideroblastic anemia Blood tests Normocytic - Microcytic - Macrocytic - Normochromic - Hypochromic Other Methemoglobinemia Coagulation / platelets / coagulopathy / bleeding[wikidoc.org] diathesis Hypercoagulability primary: Antithrombin III deficiency - Protein C deficiency / Activated protein C resistance / Protein S deficiency / Factor V Leiden - Hyperprothrombinemia[wikidoc.org]

    Missing: Absent Platelet Agglutination in Presence of Ristocetin
  • Pulmonary Hypertension

    […] ischemic attack) Bleeding and thrombotic diathesis Hemoptysis Intrapulmonary thrombosis Pulmonary hemorrhage Cerebral bleeding Menorrhagia Epistaxis Hematologic involvement[doi.org] Multiorgan Involvement in Patients With Chronic Cyanotic Congenital Heart Disease and PAH Ischemic and embolic complications Cerebrovascular accidents (stroke or transient[doi.org]

    Missing: Absent Platelet Agglutination in Presence of Ristocetin

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