Abundant Cytoplasm: Causes & Reasons

Possible Causes for Abundant Cytoplasm

[…] amphophilic cytoplasm, prominent nucleoli and large, vesicular nuclei that vary substantially in size and shape. [mendelian.co]

[…] reddish-brown dome-shaped to pedunculated, well-circumscribed papules with an average size of 5 mm, histologically predominantly composed of epithelioid melanocytes with abundant [mendelian.co]

Lipid Cell Tumor of the Ovary

Microscopic examination showed diffuse sheets of large polygonal to round tumor cells with distinct cell border, centrally placed nuclei and moderate to abundant cytoplasm [ijpmonline.org]

Microscopic examination with H-E disclosed a proliferation of sheets and nests of well demarcated polygonal cells, with abundant clear cytoplasm, and small nuclei, without [revistapatologia.com]

[…] pale (lipid-rich) cytoplasm Abundant lipid (oil red-O stain) Two atypical mitotic figures Images hosted on other servers: H&E, Oil Red O (fig 4) Diffuse sheets of large polygonal [pathologyoutlines.com]

Pulmonary Clear Cell Tumor

However, some of the lesion contained polygonal tumor cells with clear abundant cytoplasm surrounded by thin-walled vascular spaces. [ncbi.nlm.nih.gov]

As clear cell tumor of the lung contains abundant cytoplasmic glycogen, this tumor is called "sugar tumor". [semanticscholar.org]

In addition, the tumor cells were polygonal with abundant clear to eosinophilic cytoplasm and distinct cytoplasmic membranes. [ncbi.nlm.nih.gov]

Hilar Cell Tumor of the Ovary

Microscopic examination showed diffuse sheets of large polygonal to round tumor cells with distinct cell border, centrally placed nuclei and moderate to abundant cytoplasm [ijpmonline.org]

They were composed of polyhedral to rounded cells with generally abundant eosinophilic cytoplasm and often showed a perivascular aggregation of nuclei with avascular pooling [ncbi.nlm.nih.gov]

pale, vacuolated cytoplasm Enlarged, hyperchromatic, bizarre nuclei Advertisement [pathologyoutlines.com]

Leydig Cell Tumor of the Testis

Cells were polygonal with moderate to abundant eosinophilic cytoplasm and pleomorphic vesicular nuclei. [indianjcancer.com]

eosinophilic cytoplasm, round nuclei, fine chromatin, and variably conspicuous nucleoli. [ncbi.nlm.nih.gov]

Histologically, there are large round or polygonal cells with round central nucleus and abundant cytoplasm with characteristic rod-shaped Reinke crystals in 25% of cases. [sonoworld.com]

Pleomorphic Rhabdomyosarcoma

cytoplasm with cross striations characteristic of skeletal muscle differentiation. [btb.termiumplus.gc.ca]

Ascites cytology showed small clusters, sheets, and many individual large pleomorphic tumor cells with abundant vesicular cytoplasm. [jstage.jst.go.jp]

All tumors had large, often multinucleated, polygonal, spindled or strap-like rhabdomyoblasts with abundant eosinophilic cytoplasm. [ncbi.nlm.nih.gov]

Chromophobe Renal Cell Carcinoma

cytoplasm and a thickened cytoplasmic membrane. [ncbi.nlm.nih.gov]

Histopathological examination of the tumor showed solid, trabecular sheets and nesting of polygonal epithelial cells with abundant cytoplasm and prominent cell border and [ncbi.nlm.nih.gov]

Histologically, the cytoplasm was abundant granular eosinophilic and composed of solid cell sheets or pseudoacinar structures. [ncbi.nlm.nih.gov]

Pituicytoma

Ultrastructural study showed abundant cytoplasmic intermediate filaments and tumor/blood vessel basal lamina, but no desmosomes between tumor cells. [ncbi.nlm.nih.gov]

FIGURE 2 A, Mild proliferation of spindle cells with abundant cytoplasm and uniform nuclei. A fascicular pattern of growth is evident. [pediatrics.aappublications.org]

FIGURE 3 A, Solid cellular proliferation composed by groups large cells with abundant cytoplasm and sheets of medium-sized cells containing eosinophilic granules. [pediatrics.aappublications.org]

Epithelioid Cell Sarcoma

FU-EPS-1 cells were round, polygonal or spindle shaped with an abundant cytoplasm, and have been maintained continuously in vitro for over 100 passages during more than 15 [ncbi.nlm.nih.gov]

The cells are large and have abundant eosinophilic cytoplasm, mimicking a myoid tumor or epithelioid carcinoma cells. [diagnosticpathology.biomedcentral.com]

The tumor cells are spindle ( e ,×100) or round ( f ,×400) in different areas, both with abundant eocinophilic cytoplasm. [diagnosticpathology.biomedcentral.com]

Plasmablastic Lymphoma

The tumor consisted of a monotonous proliferation of undifferentiated large cells with relatively abundant cytoplasm, eccentrically located round nuclei with prominent nucleoli [ncbi.nlm.nih.gov]

[…] basophilic cytoplasm. [webpathology.com]

Histopathological examination of cells revealed eccentric nuclei and plasmacytoid features such as abundant basophilic cytoplasm. [e-crt.org]

Hairy Cell Leukemia Variant

A blood smear showed 40% medium-sized lymphocytes with abundant cytoplasm with circumferential projections, similar to those of classic hairy cells. [clinical-laboratory.blogspot.com]

There is abundant pale blue cytoplasm. Occasionally the cytoplasm is vacuolated or contains rod-shaped inclusions. [e-immunohistochemistry.info]

[…] size lymphocytes with scant to moderately abundant indistinct cytoplasm Variation in nuclear features; most commonly round with distinct, eccentric nucleoli “Fried egg” or [basicmedicalkey.com]

Benign Interstitial Cell Tumor of the Testis

Cells were polygonal with moderate to abundant eosinophilic cytoplasm and pleomorphic vesicular nuclei. [indianjcancer.com]

Histopathology The usual appearance is of sheets of polygonal cells with abundant eosinophilic cytoplasm. they may be divided by hyalinised fibrous septa into lobules. [e-immunohistochemistry.info]

Image C Image D Histology: Large, round or polygonal cells with abundant pink or vacuolated cytoplasm and well-defined cell borders (image B), (image C), & (image D). [auanet.org]

Sertoli Cell Tumor of the Testis

Leydig cell tumor Leydig cells vary in size but usually have round nuclei, single prominent nucleoli, and abundant eosinophilic cytoplasm or abundant clear cytoplasm (see [emedicine.medscape.com]

Abstract Ten cases of a distinctive testicular neoplasm characterized by large cells with abundant eosinophilic cytoplasm and calcification are reported together with two [ncbi.nlm.nih.gov]

Histologically, there are large round or polygonal cells with round central nucleus and abundant cytoplasm with characteristic rod-shaped Reinke crystals in 25% of cases. [sonoworld.com]

Primary Effusion Lymphoma

cytoplasm. [mdanderson.influuent.utsystem.edu]

Cytological analysis of the pleural effusion revealed a high-grade lymphoma with round nuclei, prominent nucleoli and abundant cytoplasm with immunophenotypes positive for [ncbi.nlm.nih.gov]

cytoplasm and irregular nuclei. [basicmedicalkey.com]

Subependymal Giant Cell Astrocytoma

Electron microscopic examination revealed abundant mitochondria in the tumor cell cytoplasm. [ncbi.nlm.nih.gov]

(histologic) images Images hosted on other servers: Large cells with abundant cytoplasm and prominent nucleoli NSE Negative stains HMB45 (unlike other tuberous sclerosis [pathologyoutlines.com]

(c) Pleomorphic tumor cells show eccentric large atypical nuclei, fine granular chromatin, occasional distinct nucleoli and abundant granular eosinophilic cytoplasm (×400) [jlponline.org]

Epulis

Microscopic features: Like adult granular cell tumour, this lesion is composed of polygonal cells with abundant granular cytoplasm and small eccentric nuclei with occasional [histopathology-india.net]

On histologic examination, it was composed of diffuse sheets and clusters of polygonal cells containing small round to oval nuclei and abundant coarsely granular cytoplasm [ncbi.nlm.nih.gov]

Histological examination of the specimen revealed characteristic large polyhedral cells with abundant granular eosinophilic cytoplasm and small round nuclei ( Fig. 4 ). [oralhealthgroup.com]

Alveolar Soft-Tissue Sarcoma

Epithelioid cells with abundant eosinophilic granular cytoplasm. Figure 5. Strong nuclear staining for TFE3. without any response. [scirp.org]

cytoplasm than seen in alveolar rhabdomyosarcomas. " Clavicular and meningeal alveolar soft part sarcoma: An unusual case and literature review. [histopathology-india.net]

Cytoplasmic vacuolation Large, rounded, polygonal cells with abundant acidophilic granular cytoplasm Positive nuclear staining for TFE3 is diagnostic of ASPS Contributed by [pathologyoutlines.com]

Primary Cutaneous Anaplastic Large-Cell Lymphoma

Anaplastic large cell lymphoma (ALCL) is characterized by proliferation of anaplastic large CD 30+ T-cell lymphoid cells with abundant cytoplasm. [ncbi.nlm.nih.gov]

Definition Cutaneous T cel lymphoma composed of >75% CD30 positive cells with pleomorphic nuclei and abundant cytoplasm Alternate/Historical Names Ki1 lymphoma Diagnostic [surgpathcriteria.stanford.edu]

cytoplasm, prominent nucleoli, and horseshoe-like or reniform nuclei), within the dermis or subcutis, with constant membrane expression of the CD30 T-cell antigen in the [orpha.net]

Astroblastoma

[…] astroblastoma [ as″tro-blas-to´mah ] an astrocytoma of Grade II, composed of cells with abundant cytoplasm and two or three nuclei. as·tro·blas·to·ma ( as'trō-blas-tō'mă ) [medical-dictionary.thefreedictionary.com]

[…] one type of slow-growing tumor comprised of neuroglial cells (see astrocytoma), whereby the cells have abundant cytoplasm and multiple nuclei. [psychologydictionary.org]

Tumor cells possessed eccentric round to oval nuclei with abundant eosinophilic cytoplasm, sometimes having cytoplasmic processes. [ncbi.nlm.nih.gov]

Leydig Cell Tumor

Histologically, the tumor was composed of large neoplastic cells with abundant eosinophilic cytoplasm with a tubular, trabecular, and solid arrangement and loose myxoid stroma [ncbi.nlm.nih.gov]

eosinophilic cytoplasm, round nuclei, fine chromatin, and variably conspicuous nucleoli. [ncbi.nlm.nih.gov]

This photomicrograph shows sheets of large polygonal cells with round nuclei, single prominent nucleolus and abundant eosinophilic cytoplasm. slide 1 of 17 ©2003-2019 WebPathology [webpathology.com]

Anaplastic Large-Cell Lymphoma

Definition Systemic CD30+ T cell lymphoma usually composed of cohesive large cells witih abundant cytoplasm and pleomorphic nuclei; half or more express anaplastic lymphoma [surgpathcriteria.stanford.edu]

Anaplastic large cell lymphoma (ALCL) is a lymphoma of T-cell origin, characterized by the presence of large lymphoid cells with abundant cytoplasm and pleomorphic, often [ncbi.nlm.nih.gov]

cytoplasm and pleomorphic nuclei Hallmark cells (“horseshoe cells”) Characteristic large cells with U-shaped or C-shaped nuclei surrounding a brightly eosinophilic Golgi [surgpathcriteria.stanford.edu]

Rosai-Dorfman Disease

cytoplasm. [ncbi.nlm.nih.gov]

The histiocytoid cells have abundant cytoplasm, vesicular nuclei, and prominent nucleoli. [rc.rcjournal.com]

Microscopic examination revealed a well circumscribed dermal lesion [Figure 1] a composed of diffuse sheets of histiocytes with abundant pale cytoplasm admixed with polymorphs [ijpmonline.org]

Paget Disease of the Breast

A malignant neoplasm in which there is infiltration of the skin by neoplastic large cells with abundant pale cytoplasm and large nuclei with prominent nucleoli (Paget cells [monarchinitiative.org]

The Diagnosis: Extramammary Paget Disease A biopsy of the plaque revealed an intraepidermal proliferation of large cells with abundant clear cytoplasm and large vesicular [mdedge.com]

Histologic Features An ulcerated surface A scale crust on the surface Paget cells with large rounded nuclei and abundant pale-staining cytoplasm occurring singly and in nests [dxpath.com]

Langerhans Cell Sarcoma

Many large cells with high-grade nuclear atypia and abundant cytoplasm were observed. Lymphocytes and eosinophils were observed in the background. [ncbi.nlm.nih.gov]

This field shows neoplastic cells with irregular nuclear contours and abundant cytoplasm. Mitotic figures are numerous. [basicmedicalkey.com]

Many large cells with high‐grade nuclear atypia and abundant cytoplasm were observed. Lymphocytes and eosinophils were observed in the background. [ingentaconnect.com]

ALK-Negative Anaplastic Large-Cell Lymphoma

Sir, Anaplastic large cell lymphoma (ALCL) is a T-cell non-Hodgkin’s lymphoma that has a histological appearance consisting of large lymphoid cells with abundant cytoplasm [medicaljournals.se]

The lesion is characterized by proliferation of anaplastic large lymphoid cells with abundant cytoplasm that strongly express CD30 antigen [ 2 ]. [thejh.org]

Clear-Cell Carcinoma of the Ovary

The neoplastic cells had abundant clear cytoplasm and moderate to severe atypia. The stroma was extensively hyalinized as it is frequently described in this entity. [hindawi.com]

The neoplastic cells form aggregates and have an abundant pale cytoplasm and uniform nuclei. [ncbi.nlm.nih.gov]

The former cells are mononucleated with vesicular nuclei, abundant clear cytoplasm, and well-defined borders; the syncytiotrophoblastic cells have abundant vacuolated basophilic [clinicalgate.com]

Fibrolamellar Hepatocellular Carcinoma

[…] granular and eosinophilic cytoplasm due to abundant mitochondria Pale or pink bodies are frequently noted but not necessary for diagnosis Typical nuclear features include [pathologyoutlines.com]

[…] granular cytoplasm is due to the presence of numerous mitochondria. [ijpmonline.org]

The fluid cytology showed atypical polygonal cells with enlarged nuclei, prominent nucleoli, and abundant granular cytoplasm. [ncbi.nlm.nih.gov]

ALK+ Histiocytosis

The lesional histiocytes were very large, with irregularly folded nuclei, fine chromatin, and abundant eosinophilic cytoplasm, sometimes with emperipolesis. [ncbi.nlm.nih.gov]

The tumor cells are usually large, round or oval and focally spindle-shaped, with abundant eosinophilic cytoplasm surrounding large bizarre pleomorphic nuclei. [spandidos-publications.com]

cytoplasm. [epathologies.com]

Hairy Cell Leukemia

cytoplasm, eccentric nuclei, often cytoplasmic projections; Fig. 2: TRAP+; Fig. 3: hypercellular bone marrow with monotonous "fried egg" lymphocytes with abundant cytoplasm [pathologyoutlines.com]

There is abundant pale blue cytoplasm. Occasionally the cytoplasm is vacuolated or contains rod-shaped inclusions. [e-immunohistochemistry.info]

They are small B lymphoid cells that possess oval nuclei and abundant cytoplasm with characteristic micro-filamentous (“hairy”) projections. [doi.org]

Gemistocytic Astrocytoma

[…] eosinophilic cytoplasm GFAP Vimentin Advertisement [pathologyoutlines.com]

(c) Pleomorphic tumor cells show eccentric large atypical nuclei, fine granular chromatin, occasional distinct nucleoli and abundant granular eosinophilic cytoplasm (×400) [jlponline.org]

[…] eosinophilic cytoplasm (Image 08 ). [path.upmc.edu]