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916 Possible Causes for Abundant Cytoplasm

  • Infectious Mononucleosis

    The medium-sized lymphocytes had round or slightly indented nuclei with a small solitary nucleoli and abundant clear cytoplasm and somewhat resembled monocytoid B-cells.[ncbi.nlm.nih.gov] However, soon after, there is an immunoblastic proliferation, which may be quite striking. 18 , 19 , 20 These cells typically have prominent nucleoli and abundant cytoplasm[doi.org] This large protein is encoded by the BLLF1 gene, is heavily glycosylated and localizes to various subcellular compartments (cytoplasm, endoplasmic reticulum, Golgi, and plasma[dx.doi.org]

  • BAP1-Related Tumor Predisposition Syndrome

    This tumor predisposition syndrome is inherited in an autosomal dominant pattern. Individuals carrying heterozygous BAP1 mutations are at high-risk for the development of a variety of tumors, including benign melanocytic tumors as well as several malignant tumors, including uveal melanoma ({155720}), cutaneous[…][diseaseinfosearch.org]

  • Hairy Cell Leukemia Variant

    A blood smear showed 40% medium-sized lymphocytes with abundant cytoplasm with circumferential projections, similar to those of classic hairy cells.[clinical-laboratory.blogspot.com] Histologically, HCL cells in bone marrow biopsies have abundant cytoplasm surrounding the nuclei, resembling a fried egg.[karger.com] […] size lymphocytes with scant to moderately abundant indistinct cytoplasm Variation in nuclear features; most commonly round with distinct, eccentric nucleoli “Fried egg” or[basicmedicalkey.com]

  • Primary Cutaneous Anaplastic Large Cell Lymphoma

    Abstract Anaplastic large cell lymphoma (ALCL) is characterized by proliferation of anaplastic large CD 30 T-cell lymphoid cells with abundant cytoplasm.[ncbi.nlm.nih.gov] cytoplasm, round / oval / irregular nuclei, prominent eosinophilic nucleoli) Nonanaplastic appearance (pleomorphic or immunoblastic) is less common (20% - 25%) Ulcerating[pathologyoutlines.com] cytoplasm 20% of cases appear nonanaplastic (pleomorphic or immunoblastic) ANCILLARY TESTS Immunohistochemistry 75% of neoplastic large cells are CD30( ) Activated CD4( )[basicmedicalkey.com]

  • Langerhans Cell Sarcoma

    Many large cells with high-grade nuclear atypia and abundant cytoplasm were observed. Lymphocytes and eosinophils were observed in the background.[ncbi.nlm.nih.gov] This field shows neoplastic cells with irregular nuclear contours and abundant cytoplasm. Mitotic figures are numerous.[basicmedicalkey.com] Many large cells with high‐grade nuclear atypia and abundant cytoplasm were observed. Lymphocytes and eosinophils were observed in the background.[ingentaconnect.com]

  • Neutropenia and Hyperlymphocytosis with Large Granular Lymphocytes

    Small unremarkable lymphs will be seen, but also enlarged lymphocytes with abundant blue cytoplasm will be noted.[writenowservices.com] cytoplasm containing coarse azurophilic granules Bone marrow : variable cellularity, myeloid series shifted to immaturity, mild to moderate reticulin fibrosis, interstitial[pathologyoutlines.com] Cytology Large granular lymphocytes (LGLs) with the nucleus of a small lymphocyte but abundant cytoplasm and fine or coarse azurophilic granules; ultrastructural examination[atlasgeneticsoncology.org]

  • Chromophobe Renal Cell Carcinoma

    Histopathological examination of the tumor showed solid, trabecular sheets and nesting of polygonal epithelial cells with abundant cytoplasm and prominent cell border and[ncbi.nlm.nih.gov] cytoplasm and a thickened cytoplasmic membrane.[ncbi.nlm.nih.gov] Histologically, the cytoplasm was abundant granular eosinophilic and composed of solid cell sheets or pseudoacinar structures.[ncbi.nlm.nih.gov]

  • Subependymal Giant Cell Astrocytoma

    Electron microscopic examination revealed abundant mitochondria in the tumor cell cytoplasm.[ncbi.nlm.nih.gov] (histologic) images Images hosted on other servers : Large cells with abundant cytoplasm and prominent nucleoli NSE Negative stains HMB45 (unlike other tuberous sclerosis[pathologyoutlines.com] Histologic findings revealed fibrillated spindle tumor cells and giant tumor cells with abundant cytoplasm.[ncbi.nlm.nih.gov]

  • Sertoli Cell Tumor of the Testis

    Abstract Ten cases of a distinctive testicular neoplasm characterized by large cells with abundant eosinophilic cytoplasm and calcification are reported together with two[ncbi.nlm.nih.gov] Leydig cell tumor Leydig cells vary in size but usually have round nuclei, single prominent nucleoli, and abundant eosinophilic cytoplasm or abundant clear cytoplasm (see[emedicine.medscape.com] Ultrastructurally, neoplastic cells had cytoplasmic processes and abundant rough endoplasmic reticulum and lipid droplets in the cytoplasm.[ncbi.nlm.nih.gov]

  • Hairy Cell Leukemia

    They are small B lymphoid cells that possess oval nuclei and abundant cytoplasm with characteristic micro-filamentous (“hairy”) projections.[doi.org] They are small B lymphoid cells that possess oval nuclei and abundant cytoplasm with characteristic micro-filamentous ("hairy") projections.[ncbi.nlm.nih.gov] cytoplasm, eccentric nuclei, often cytoplasmic projections; Fig. 2: TRAP ; Fig. 3: hypercellular bone marrow with monotonous "fried egg" lymphocytes with abundant cytoplasm[pathologyoutlines.com]

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