Acanthocytes: Causes & Reasons

Possible Causes for Acanthocytes

These thorny cells are called acanthocytes. [en.wikipedia.org]

In this study, acanthocytes from a patient with chorea-acanthocytosis and a patient with McLeod syndrome were examined. [karger.com]

Acanthocytes – blood smear is taken from patient with Abetalipoproteinemia Acanthocytes ( spur cells ) are spiculated red cells with a few projections of varying size and [askhematologist.com]

McLeod Neuroacanthocytosis Syndrome

A peripheral blood smear showed 5% acanthocytes. McLeod syndrome was confirmed by immunohematology. [hum-molgen.org]

McLeod syndrome is one of only a few disorders in which acanthocytes may be found on the peripheral blood smear. Blood evaluation may show signs of hemolytic anemia. [en.wikipedia.org]

The mechanism of acanthocyte formation in chorea-acanthocytosis is unknown. [neurologyindia.com]

Erythrocyte Membrane Abnormality

/acanthocytic morphology. [alpfmedical.info]

Acanthocytes show little to no central pallor. Both acanthocytes and echinocytes occur due to membrane abnormalities of the RBC. [theartofmed.wordpress.com]

Acanthocytes have abnormal red cell membrane lipid composition. The associated hemolysis is mild and rarely requires therapy. [mhmedical.com]

Acquired Spherocytosis

Acanthocytes Acanthocytes are seen in •Hereditary abetalipoproteinemia •Hereditary acanthocytosis •End stage liver disease •Anorexia nervosa •Malnutrition •Post splenectomy [slideshare.net]

Acanthocytes have abnormal red cell membrane lipid composition. The associated hemolysis is mild and rarely requires therapy. [mhmedical.com]

Flow Cytometry of CD55 and CD59 -Mild-to-moderate liver disease causes target red cells -Severe liver disease is associated with acanthocytes (spur cells) -Hemolysis is mostly [quizlet.com]

Hereditary Cryohydrocytosis with Reduced Stomatin

ACANTHOCYTOSIS Spiculated red cells are classified into two types, acanthocytes and echinocytes. [medtextfree.wordpress.com]

Other hereditary membrane defects with acanthocytes Acanthocytes (spur cells) are small, dense RBCs with a few irregular projections that vary in width, length, and surface [doctorlib.info]

35) § % hyperdense cells increased § RDW increased § Retics increased Film § Freshly made film as features of stomatocytosis can be obscured in old films § Spherocytes § Acanthocytes [ihaematology.com]

Abetalipoproteinemia

indicating that acanthocyte membrane lipids are more ordered. [doi.org]

It was increased from 3.2+/-0.1 poise in normals to 4.01-4.14 poise in acanthocytes. [ncbi.nlm.nih.gov]

[…] and retinitis pigmentosa, low plasma cholesterol, triglyceride and LDL cholesterol levels, absence of beta-band in lipoprotein electrophoresis and existence of circulating acanthocytes [turkjem.org]

Congenital Heinz Body Hemolytic Anemia

[…] resemble spurs on cowboy boots, but they have uneven projections (spicules) Acanthocytes are the rbc's seen with projections of spicules around the surface A single acanthocyte [hematologylearning.weebly.com]

Sickle cell anaemia Sickle thalassaemia Sickle Cells Acanthocytes (Spur Cell): Congenital abetalipoproteinemia Vitamin E deficiency Alcohol intoxication Post-splenectomy Acanthocytes [medical-labs.net]

Acanthocytes show little to no central pallor. Both acanthocytes and echinocytes occur due to membrane abnormalities of the RBC. [theartofmed.wordpress.com]

Vitamin E Deficiency

Four patients had accumulation of ceroid in smooth muscle (lipofuscinosis), which indicated severe or uncontrolled malabsorption, with confirmed vitamin E deficiency in three cases. The distribution of the pigment was systematic, and there seemed to be an association between malabsorption syndrome and vitamin E[…] [ncbi.nlm.nih.gov]

Zieve's Syndrome

It is defined by hemolytic anemia (with spur cells and acanthocytes/schistocytes), hyperlipoproteinemia (excessive blood lipoprotein), jaundice (elevation of unconjugated [quizlet.com]

It is defined by hemolytic anemia (with spur cells and acanthocytes), hyperlipoproteinaemia (excessive blood lipoprotein), jaundice (elevation of unconjugated bilirubin), [en.wikipedia.org]

It is defined by hemolytic anemia (with spur cells and acanthocytes), hyperlipoproteinaemia (excessive blood lipoprotein ), jaundice (elevation of unconjugated bilirubin ) [howlingpixel.com]

Familial Hypobetalipoproteinaemia Type 1

[…] cholesterol Types: abetalipoproteinemia a rare inherited disorder of fat metabolism; characterized by severe deficiency of beta-lipoproteins and abnormal red blood cells (acanthocytes [vocabulary.com]

Neurologic Syndromes with Acanthocytes. In: Merritt’s Neurology, 12th ed. Rowland LP, Pedley TA, editors. Lippincott Williams & Wilkins, Philadelphia, PA. 2010:665-668. [rarediseases.org]

Clinical features include fat malabsorption, progressive ataxia (spinocerebellar degeneration), acanthocytic red blood cells and retinitis pigmentosa. [patient.info]

Huntington Disease-Like Type 2

Acanthocytes were detected in 4 of the 13 patients tested. Nineteen out of 20 MRIs were reported as abnormal with findings similar to HD. [ncbi.nlm.nih.gov]

[…] a clear history of AD chorea in family of African ancestry and no other suggestive features, consider HDL2. one helpful feature in a small proportion is the presence of acanthocytes [slideshare.net]

Proposed specific differences include an exclusive African ancestry, lack of eye movement abnormalities, increased Parkinsonism, and acanthocytes in HDL2. [ncbi.nlm.nih.gov]

Red Blood Cell Disorder

Acanthocytes show little to no central pallor. Both acanthocytes and echinocytes occur due to membrane abnormalities of the RBC. [theartofmed.wordpress.com]

Topics include macrocytosis, intracellular RBC inclusions, echinocytes and acanthocytes, schistocytes, ovalocytes, and rouleaux. [medialabinc.net]

Senile Chorea

Kayser–Fleischer rings; mutations in ATP7B Other hereditary disorders Mitochondrial disordersMultiple types; maternal inheritance NeuroacanthocytosisSeveral conditions characterized by acanthocytes [clinchem.aaccjnls.org]

An examination of wet blood or Wright-stained, fast dry, blood smear usually reveals over 15% of red blood cells as acanthocytes. [clinicalgate.com]

The peripheral blood smear revealed no abnormal cell or acanthocytes. Renal, hepatic and other metabolic profiles were normal. [annsaudimed.net]

Cholesterol Ester Storage Disease

Peripheral blood showed macrocytic anemia with mild neutropenia, thrombocytopenia, and acanthocytes. [ashpublications.org]

Neurodegeneration with Brain Iron Accumulation

Blood smear showed a large number of acanthocytes (Figure 1). Figure 1. Blood smear shows numerous acanthocytes. [demneuropsy.com.br]

Neuroacanthocytosis presents with progressive peripheral neuropathy, ataxia, retinitis pigmentosa, oromandibular dyskinesias and acanthocytes in the peripheral smear. [e-ijd.org]

Since the discovery of PANK2, it has been established that the association of hyperprebetalipoproteinaemia, acanthocytes, and retinitis pigmentosa (HARP) is within the PKAN [doi.org]

Acantholytic Acanthoma

Woronets Trait

•Acanthocytes – (See 'Causes of acanthocytes' above and 'Laboratory testing unexplained burr cells or acanthocytes' above.) -Liver disease – Liver function tests. [medilib.ir]

ECHINOCYTES AND ACANTHOCYTES Definitions — Echinocytes and acanthocytes are two types of spiculated red blood cells. [uptofate.icu]

Spherocytes, keratocytes, and acanthocytes were not observed in this fraction. [nature.com]

Macrocytic Hyperchromic Anemia

Thalassemia Iron Deficiency Target Cells: Central and outer rim staining with intervening ring of pallor Liver disease Thalessemia Hemoglobin C disease Sickle cell disease Acanthocytes [meddean.luc.edu]

Panel D shows target cells (short arrow), acanthocytes (long arrow), and a Howell–Jolly body (arrowhead) — all features of hyposplenism — in a blood smear from a patient with [mytestdiagnostics.com]

X-Linked Alport Syndrome

Revista Brasileira de Oftalmologia Print version ISSN 0034-7280 On-line version ISSN 1982-8551 Rev. bras.oftalmol. vol.75 no.5 Rio de Janeiro Sept./Oct. 2016 http://dx.doi.org/10.5935/0034-7280.20160079 Relato de Casos Posterior polymorphous corneal dystrophy in X linked Alport syndrome Distrofia corneana polimorfa[…] [scielo.br]

Dimorphic Anemia

Sickle cells Sickle cell anemia Sickle-thalassemia Stomatocytes Malignant tumors Acute alcoholism Burr cells Renal diseases Liver diseases Bleeding gastric ulcer Severe burns Acanthocytes [labpedia.net]

hereditary spherocytosis (DAT-) Bite cells: G6PD deficiency Target cells: hemoglobinopathy or liver disease Schistocytes: TTP/HUS, DIC, prosthetic valve, malignant HTN Acanthocytes [ncbi.nlm.nih.gov]

Fibular Dimelia-Diplopodia Syndrome

Acanthia lectularia Acanthion " "" " AcanthoAll-purpose syringe Acanthocephala All-purpose syringe tip Acanthocephaliasis Acanthocheilonema persta Acanthocheilonemiasis Acanthocyte [pdfslide.us]

HARP Syndrome

Thus, defective membrane repair may be the molecular basis for acanthocyte formation in PKAN. [link.springer.com]

Phase-contrast microscopy of whole blood showed 80-90% acanthocytes, confirmed by electron microscopy. [pediatricneurologybriefs.com]

Muthane UB, Shetty R, Panda K, Yasha TC, Jayakumar PN, Taly AB. (1999) Hallervorden Spatz disease and acanthocytes. Neurology 53: 32A. PubMed Google Scholar 9. [link.springer.com]

Huntington Disease-Like Type 3

Complete blood count testing reveals acanthocytes, hemolytic anemia. Serum creatine kinase is elevated. [online.epocrates.com]

[…] but several differences are noted among their clinical symptoms. [5] To understand the pathophysiology of these disorders, research into the common biological pathway of acanthocyte [n.neurology.org]

[…] patient and for currently asymptomatic family members who may also be affected. 1 Other testing includes: Complete blood count Creatine phosphokinase Peripheral smear for acanthocytes [mdedge.com]

Huntington Disease-Like Syndrome

Although the presence of acanthocytes may improve the diagnostic accuracy, their absence does not rule out the diagnosis of ChAc29. [scielo.br]

[…] juvenile HD have been reported.[22] Pathological examination has shown a picture similar, but not identical, to that of classic HD.[17,22,23] In about 10% of cases with HDL2, acanthocytes [medscape.org]

Neuroacanthocytosis syndromes (chorea-acanthocytosis, McLeod syndromes, HDL2, PKAN) are obviously characterised by the presence of increased percentages of acanthocytes in [jnnp.bmj.com]

Hereditary Cryohydrocytosis with Normal Stomatin

ACANTHOCYTOSIS Spiculated red cells are classified into two types, acanthocytes and echinocytes. [medtextfree.wordpress.com]

Abetalipoproteinemia Low serum cholesterol but increased sphingomyelin which enters the cells producing acanthocytes. [sites.google.com]

Other hereditary membrane defects with acanthocytes Acanthocytes (spur cells) are small, dense RBCs with a few irregular projections that vary in width, length, and surface [doctorlib.info]

Chorea

Subsequent development of choreic involuntary movements, evidence of striatal atrophy on MRI and detection of acanthocytes in a peripheral blood smear allowed diagnosis. [ncbi.nlm.nih.gov]

Chorea-acanthocytosis (Ch-Ac) is an autosomal recessive neurodegenerative disorder characterized by adult-onset chorea, acanthocytes in the peripheral blood, and Huntington's [ncbi.nlm.nih.gov]

Peripheral blood smear examination revealed acanthocytes in our patient. [ncbi.nlm.nih.gov]

Hallervorden-Spatz Syndrome

Two patients had acanthocytes in peripheral blood smear. [ncbi.nlm.nih.gov]

Peripheral blood film did not reveal acanthocytes. [ncbi.nlm.nih.gov]

The association of hyperprebetalipoproteinemia, acanthocytes and retinitis pigmentosa (HARP syndrome) is within the PKAN spectrum. [orpha.net]

Overhydrated Hereditary Stomatocytosis

ACANTHOCYTOSIS Spiculated red cells are classified into two types, acanthocytes and echinocytes. [medtextfree.wordpress.com]

[…] disorders characterized by neurologic impairment and acanthocytes on the PBF -3 disorders in this group: 1. abetalipoproteinemia 2. [quizlet.com]

Normocytic Normochromic Anemia

Acanthocytes in abetalipoproteinemia E. Acanthocytes and Howell-jolly bodies in liver diseas F. Autoagglutination in cold agglutinin disease Second Color Plate upper A. [pitt.edu]

Bite cells and/or blistor cells for oxidative hemolysis, Acanthocytes for pyruvate kinase deficiency or McLeod phenotype, Sickle cells for sickle cell anemia, Spherocytes [en.wikipedia.org]

Acanthocheilonemiasis

[…] ma -ˌkī-lə-ˈnē-mə : a common genus of tropical filarial worms parasitic in humans and monkeys Dictionary Entries Near Acanthocheilonema acanthocephalan Acanthocheilonema acanthocyte [merriam-webster.com]