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176 Possible Causes for Acanthosis Nigricans, Early Onset Puberty

  • Insulin Resistance

    Acanthosis nigricans (AN) is a cutaneous marker for many underlying states such as endocrine abnormality, obesity, certain drugs, and malignancy.[ncbi.nlm.nih.gov] Early onset of reproductive function in normal female mice treated with leptin. Science 275, 88–90 (1997). 27 Montague, C. T. et al.[doi.org] ., Ph.D. 5 Citing Articles A 27-year-old woman presented with a 2-year history of acanthosis nigricans (Panels A and B), hirsutism, and amenorrhea.[nejm.org]

  • Polycystic Ovary Syndrome

    Groups A and C showed increased frequency of acanthosis nigricans compared with Group B.[ncbi.nlm.nih.gov] Fewer menstrual cycles in early puberty can translate into less estrogen to develop mammary tissue.[mobimotherhood.org] The first patient had hyperandrogenic, insulin-resistant acanthosis nigricans syndrome and had been resistant to multiple courses of clomiphene citrate; the second exhibited[ncbi.nlm.nih.gov]

  • Obesity

    Obesity is a chronic disease that may lead to skin problems, including acanthosis nigricans, skin tags, hyperandrogenism, striae distensae, plantar hyperkeratosis, and candidal[ncbi.nlm.nih.gov] The administration of leptin permitted progression of appropriately timed pubertal development in the single child of appropriate age and did not cause the early onset of[doi.org] Complications of obesity include cardiovascular risks, hypertension, dyslipidemia, endothelial dysfunction, type 2 diabetes mellitus and impaired glucose tolerance, acanthosis[ncbi.nlm.nih.gov]

  • Familial Partial Lipodystrophy

    FPLD 2 should be considered in the differential diagnosis of diabetes, dyslipidemia, steatohepatitis, acanthosis nigricans and polycystic ovary syndrome.[ncbi.nlm.nih.gov] A wide clinical spectrum of muscular features might be encountered, ranging from invalidating myopathy of early disclosure to mild delayed-onset muscular dystrophy.[academic.oup.com] Features included fat loss, severe insulin resistance, fatty liver, acanthosis nigricans and diabetes.[en.wikipedia.org]

  • Hypochondroplasia

    We report a child who presented with extensive acanthosis nigricans, short stature, and radiographic evidence of hypochondroplasia.[ncbi.nlm.nih.gov] The AN considerably increased and darkened in the periods of puberty onset and pregnancy. Download Figure Figure 5 Skin biopsy.[eje.bioscientifica.com] We present a 14-year-old girl with mild hypochondroplasia who developed acanthosis nigricans.[ncbi.nlm.nih.gov]

  • Cushing's Disease

    Early onset of puberty has been reported after whole-brain irradiation for childhood leukemias ( 31 ).[doi.org] Gonadotropin secretion may be disturbed after whole-brain or pituitary irradiation, puberty being either early or delayed.[doi.org] With the exception of early puberty in one of our patients ( 20 ), no abnormalities of gonadal function were observed.[doi.org]

  • Donohue Syndrome

    DS is characterized by pre- and postnatal growth retardation with failure to thrive, lipoatrophy, muscle wasting, acanthosis nigricans, hypertrichosis, and dysmorphic features[ncbi.nlm.nih.gov] Early onset of puberty Early puberty [ more ] 0000826 Recurrent infections Frequent infections Frequent, severe infections Increased frequency of infection infections, recurrent[rarediseases.info.nih.gov] She presented not only polydipsia, polyphagia, and weight loss but also small elfin face, distended abdomen, enlarged clitoris, hypertrichosis, acanthosis nigricans of the[ncbi.nlm.nih.gov]

  • Hypertrichosis

    Other paraneoplastic skin conditions that may also occur with acquired hypertrichosis lanuginosa include acquired ichthyosis, acanthosis nigricans, and tripe palms.[dermnetnz.org] ) • Late onset congenital adrenal hyperplasia – (due to hormone metabolism changes at puberty) • Pregnancy related – e.g. ovarian changes or hyperprolactinemia (increased[hairscientists.org] It may occur with other paraneoplastic skin conditions (acanthosis nigricans, papillary hypertrophy of the tongue, glossitis).[meducator3.net]

  • Acne Vulgaris

    nigricans, patterned hair loss, or deepened voice.[ncbi.nlm.nih.gov] onset of acne, at the age of 8 or 9, in line with epidemiological data, suggesting earlier start of puberty. 25 Table 3 shows an increase in the prevalence of inflammatory[scielo.br] Acanthosis nigricans, Papillomatosis mucosae und “tripe palms” bei einem Patienten mit metastasiertem Adenokarzinom des Magens.[ncbi.nlm.nih.gov]

  • Precocious Puberty

    Decreased insulin sensitivity in prepubertal girls with premature adrenarche and acanthosis nigricans. J Clin Endocrinol Metab 1995 ; 80 : 614 –18.[doi.org] The signs and symptoms of Precocious Puberty in girls include: Early growth of breasts Onset of menstruation and ovulation The signs and symptoms of Precocious Puberty in[dovemed.com] Precocious Puberty Early onset puberty appears to be occurring at a decreasing age in the United States.[newportchildren.com]

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