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25 Possible Causes for acetylase, binding, histone

  • Clofibrate

    Spin-labeled clofibrate binding to LDL is enhanced when the temperature increases above 25 degrees C. The binding to HDL and VLDL is less temperature-sensitive.[] High level of coactivators steroid receptor coactivator-1 (SRC-1) and histone acetylase CBP-300 (CREB binding protein-300) were observed in the nuclear complexes of clofibrate[] The strong binding of I and VI to ultrafiltration membranes necessitated the determination of their plasma protein binding by the method of variable plasma concentrations[]

  • B-Cell Chronic Lymphocytic Leukemia

    The ATP-binding cassette is involved in drug metabolism, and the polymorphism of this gene may be an important risk factor in B cell chronic lymphocytic leukemia (B-CLL) or[] Inhibiting histone deacetylase (HDAC) has emerged as a promising strategy to induce cell death in malignant cells.[] […] describe a new subset of M-CLL, expressing stereotypic BCRs highly specific for β-(1,6)-glucan, a major antigenic determinant of yeasts and filamentous fungi. β-(1,6)-glucan binding[]

  • Ptosis

    FOXL2 encodes a forkhead transcription factor that contains a typical DNA-binding forkhead domain and a polyalanine tract of 14 residues strictly conserved in mammals.[] The protein variant shows an aberrant cellular location, loss of certain protein interactions, and decreased histone H3K23 acetylation.[] BRPF1 encodes a protein modifier of two histone acetyltransferases associated with ID: KAT6A (also known as MOZ or MYST3) and KAT6B (MORF or MYST4).[]

  • Cutaneous T-Cell Lymphoma

    Gov't MeSH terms Apoptosis Blotting, Western Cell Line, Tumor Core Binding Factor Alpha 3 Subunit/biosynthesis Core Binding Factor Alpha 3 Subunit/genetics* DNA Methylation[] Biology of Histone Deacetylases and Their Inhibitors HDACs and histone acetylases (HATs) are key enzymes that remove or add acetyl groups to proteins including histones. 9,10[] Histone deacetylase (HDAC) inhibitors (HDACis) are recently developed therapeutics approved for refractory CTCL.[]

  • Acute Monocytic Leukemia

    Abstract 54 kDa nuclear RNA- and DNA-binding protein (p54nrb) which is also called non-POU domain-containing octamer-binding protein (NONO) is known to be multifunctional[] The relation of histone acetylase and therapy-related leukemia is discussed.[] Monocytic leukemia zinc finger protein (MOZ) has histone acetyltransferase activity.[]

  • Follicular Lymphoma

    Antibody binding to CD20 activates the immune system to attack and kill the cancerous B cells, and makes the cells more susceptible to chemotherapy.[] In FL in particular, recurrent mutations have been reported in the histone methyltransferases MLL2 (89%) and EZH2 (7.2%), the histone acetylases CREBBP (32.6%), EP300 (8.7%[] Abstract The histone methyltransferase EZH2 has an essential role in the development of follicular lymphoma (FL).[]

  • Familial Dysautonomia

    Characterization of the cis elements and trans factors involved in the digoxin-mediated effect on splicing reveals that this response is dependent on an SRSF3 binding site[] […] disease of the autonomic and sensory nervous systems, involves mutations in the protein IkappaB kinase complex-associated protein, which is a component of the human Elongator acetylase[] Further PS treatment resulted in recovery of axonal outgrowth and enhanced retrograde axonal transport by decreasing histone deacetylase 6 (HDAC6) levels and thus increasing[]

  • Glioblastoma Multiforme

    Here we demonstrated an oncogenic role of PD-L1 via binding and activating Ras in GBM cells.[] […] methyltransferase (5-azacytidin and decitabin) were approved by the Food and Drug Administration (FDA) in the treatment of myelodysplastic syndrome and a few inhibitors of histone acetylases[] Inhibition of histone acetylation via histone deacetylase inhibitor (HDACI) is one such strategy.[]

  • Shigella Flexneri

    Our four other HTS hit compounds do not inhibit DNA binding and yet they do block VirF activity.[] PubMed Google Scholar Clark CA, Beltrame J, Manning PA: The oac gene encoding a lipopolysaccharide O-antigen acetylase maps adjacent to the integrase-encoding gene on the[] Heterochromatin Protein 1 family members specifically recognize and bind histone H3 methylated at Lys 9.[]

  • Congenital Generalized Fibromatosis

    Independent of CDK, cyclin D1 binds to receptors to regulate cell proliferation, growth.[] The binding of factors to the extra-cellular part leads to detachment of the intra-cellular part, in order for it to influence cellular processes Mutations in this gene are[] Thus, it has been said that both JHF and ISH are allelic, and they belong to the spectrum of the same disorder. [8] CMG2 is an integrin-like cell surface receptor that binds[]