Activated Partial Thromboplastin Time Prolonged: Causes & Reasons

Possible Causes for Activated Partial Thromboplastin Time Prolonged

On admission, the patient's activated partial thromboplastin time (aPTT) was prolonged (271 s), and activated clotting time was 500 s. His factor XII level was <3%. [ncbi.nlm.nih.gov]

Seven women were found to have reduced FXII activity (19. 2-46.1%) and prolonged activated partial thromboplastin time (33. 3-51.3 s). [ncbi.nlm.nih.gov]

In the majority of cases, patients remain asymptomatic, with the only pathologic finding being the prolonged activated partial thromboplastin time (aPTT) detected via laboratory [symptoma.com]

Acquired Hemophilia

The laboratory revealed isolated activated partial thromboplastin time prolongation with low FVIII activity and a presence of FVIII inhibitor. [ncbi.nlm.nih.gov]

Prothrombin time was within normal range, but activated partial thromboplastin time was prolonged. [ncbi.nlm.nih.gov]

Her activated partial thromboplastin time was prolonged (80.0 s). [ncbi.nlm.nih.gov]

Coagulation Abnormalities

An isolated abnormal prothrombin time (PT) suggests FVII deficiency, whereas a prolonged activated partial thromboplastin time (aPTT) indicates most commonly hemophilia or [accessmedicine.mhmedical.com]

Activated partial thromboplastin time was prolonged in47 (57.31 % ) patients, while35 (42.68 % ) patients had normal APTT which was less than 40 seconds (mean + SD = 33.05 [pacificejournals.com]

The activated partial thromboplastin time was accelerated in both groups of patients. [annals.org]

Factor V Deficiency

On preliminary investigations her prothrombin time and activated partial thromboplastin time were prolonged. [ncbi.nlm.nih.gov]

[…] or reduced Bleeding time Normal Normal or prolonged Prothrombin time Normal Normal Activated partial thromboplastin time Prolonged Normal or prolonged Table 3 Screening blood [academic.oup.com]

[…] bleeding time Diagnosis factor V assay (showing decreased activity) activated partial thromboplastin time (aPTT) test (prolonged) prothrombin time (PT) test (prolonged) thrombin [rnpedia.com]

Acquired Hemophilia A

The laboratory revealed isolated activated partial thromboplastin time prolongation with low FVIII activity and a presence of FVIII inhibitor. [ncbi.nlm.nih.gov]

Her activated partial thromboplastin time was prolonged (80.0 s). [ncbi.nlm.nih.gov]

Prothrombin time was within normal range, but activated partial thromboplastin time was prolonged. [ncbi.nlm.nih.gov]

Factor X Deficiency

The proposita showed a markedly prolonged activated partial thromboplastin time and a mild prolongation of prothrombin time. [ncbi.nlm.nih.gov]

The international normalized ratio (6.01) and activated partial thromboplastin time (117 s) were prolonged. [ncbi.nlm.nih.gov]

Both the prothrombin time and the activated partial thromboplastin time were markedly prolonged in nearly all patients. [onlinelibrary.wiley.com]

Factor II Deficiency

LA-HPS is to be suspected when a patient presents with bleeding and a prolonged activated partial thromboplastin and prothrombin time, in combination with a lupus anticoagulant [ncbi.nlm.nih.gov]

Diagnostic methods Diagnosis is based on prolonged prothrombin and activated partial thromboplastin times (PT, aPTT) and on low FII coagulant activity measured using a PT [orpha.net]

Hereditary Factor XI Deficiency

Severe Factor XI (FXI) deficiency is defined when the activated partial thromboplastin time is prolonged and its activation is <1-15 UdL(-1) in plasma. [ncbi.nlm.nih.gov]

During 1 year of post-transplant follow-up, his activated partial thromboplastin time (aPTT) remained prolonged, but he did not develop bleeding complications. [ncbi.nlm.nih.gov]

A 42-year-old-women with sigmoid colon adenocarcinoma was found to have isolated prolonged activated partial thromboplastin time (aPTT 102.5 s, normal range 24-36 s) preoperatively [ncbi.nlm.nih.gov]

Hereditary Factor X Deficiency

The propositus had a markedly prolonged prothrombin time, a mild prolongation of activated partial thromboplastin time and a clotting time activated by Russell's viper venom [ncbi.nlm.nih.gov]

However, a high index of suspicion should follow an abnormal clotting profile with prolonged PT (prothrombin time) and APTT (activated partial thromboplastin time). [symptoma.com]

Diagnostic methods Diagnosis is based on prolonged prothrombin, activated partial thromboplastin, and Russell viper venom times (PT, aPTT, RVVT), and on reduced levels of [orpha.net]

Disseminated Intravascular Coagulation

Prothrombin time (PT) – normal or prolonged Activated partial thromboplastin time (aPTT) – normal or prolonged (may be normal in early or chronic DIC) Thrombin time (TT) [arupconsult.com]

Prothrombin and activated partial thromboplastin times are prolonged. [stago-us.com]

[…] prothrombin time (PT) prolonged international normalized ratio (INR) prolonged activated partial thromboplastin time (aPTT) schistocytes on blood smear due to microangiopathic [radiopaedia.org]

Hereditary Factor I Deficiency

Bleeding time (BT) was prolonged beyond 15 minutes. prothrombin time (PT), activated partial thromboplastin time (APTT) and thrombin time (TT) were prolonged infinitely. [jpma.org.pk]

Diagnostic methods Diagnosis is based on prolonged activated partial thromboplastin time (aPTT), prothrombin time (PT), thrombin and reptilase times and on fibrinogen levels [orpha.net]

Laboratory studies showed prolongation of prothrombin time, activated partial thromboplastin time, and undetectably low level of fibrinogen. [ncbi.nlm.nih.gov]

Hereditary Coagulopathy

Patients referred due to a prolonged activated partial thromboplastin time with bleeding more frequently (41.7%) present coagulopathy with a real risk of bleeding. [analesdepediatria.org]

Haemostasis tests in bleeding disorders [ 1, 21 ] Platelet count Prothrombin time Activated partial thromboplastin time Bleeding time Thrombin time Additional tests Haemophilia [patient.info]

FXIIa deficiency has been shown to be associated with a prolonged activated Partial Thromboplastin Time (aPTT), suggesting that FXII has a useful predictive value of the vascular [omicsonline.org]

Hereditary Factor I Deficiency

Since bleeding time is usually normal, diagnosis is made by a prolonged activated partial thromboplastin time (aPTT) test. [myneighborhoodprimarycare.org]

Screening coagulogram was performed, which showed marked prolongation of prothrombin time (93'/13'), activated partial thromboplastin time (145'/30'), and thrombin time (45 [ehj.eg.net]

Activated partial thromboplastin time was prolonged and Quick values were low but ROTEM clotting time values remained normal, therefore, no thrombin-generating drugs were [aetna.com]

Hemophilia B

In laboratory tests, isolated prolongation of activated partial thromboplastin time (aPTT) can be found, but it is necessary to determine the plasma levels of factor VIII [ncbi.nlm.nih.gov]

The diagnosis of hemophilia B is typically suspected by significantly prolonged activated partial thromboplastin time (aPTT) on screening tests, but aPTT may be normal or [ncbi.nlm.nih.gov]

The patient was diagnosed with hemophilia B based on the results of a detailed inquiry, a mildly prolonged activated partial thromboplastin time, and low factor IX activity [ncbi.nlm.nih.gov]

Bleeding Diathesis

Studies revealed prolonged prothrombin time and activated partial thromboplastin time. [ncbi.nlm.nih.gov]

Plasma from affected family members had prolonged prothrombin times and activated partial thromboplastin times, low to below normal factor X coagulant activity, and normal [ncbi.nlm.nih.gov]

If ratios of prothrombin time and/or activated partial thromboplastin time were prolonged, the activity of clotting factors was measured. [pediatrics.aappublications.org]

Hemophilic Arthropathy

In laboratory tests, isolated prolongation of activated partial thromboplastin time (aPTT) can be found, but it is necessary to determine the plasma levels of factor VIII [ncbi.nlm.nih.gov]

In patients with hemophilia, prothrombin time and platelet count are normal, and activated partial thromboplastin time is prolonged, denoting a defect in the intrinsic clotting [musculoskeletalkey.com]

and severe (< 1 % activity). [ncbi.nlm.nih.gov]

Hemophilia A

normal Platelet count: normal Activated partial thromboplastin time (aPTT): usually prolonged If aPTT prolonged → mixing study If mixing study is positive (or if patient [amboss.com]

activated partial thromboplastin time with a normal prothrombin time. [doi.org]

The CBC will reveal normal platelet levels while the coagulation studies demonstrate normal bleeding time (BT) and prothrombin time (PT) but prolonged activated partial thromboplastin [symptoma.com]

Passovoy Factor Defect

activated partial thromboplastin time (APTT). [acronymattic.com]

thromboplastin time (APTT). [ncbi.nlm.nih.gov]

A condition described in 1975 as an autosomal dominant bleeding disorder, which was characterised by a prolonged activated partial thromboplastin time (APTT). [medical-dictionary.thefreedictionary.com]

Hemophilia

activated partial thromboplastin time (aPTT).One will find that the factor XI has decreased in the individuals body. [en.wikipedia.org]

AHA should be suspected when a patient with no previous history of bleeding presents with bleeding and an unexplained prolonged activated partial thromboplastin time. [doi.org]

FVIII binding activity is present, but there is prolonged activated partial thromboplastin time (aPTT) and reduced FVIII activity (FVIII:C).1,2 The diagnosis is completed [touchoncology.com]

Purpura Fulminans

Laboratory investigations documented thrombocytopenia (90×109/L), elevated prothrombin time (17.6 s), prolonged activated partial thromboplastin time (53.5 s) along with elevated [pmj.bmj.com]

Bleeding time was normal but prothrombin time and activated partial thromboplastin time reports were prolonged. D-dimer levels were elevated. [ijpd.in]

Blood tests showed anti-prothrombin antibodies and prolonged activated partial thromboplastin and prothrombin times which were uncorrected by plasma-mixing studies. [thelancet.com]

Vitamin K Deficiency

All the infants had prolonged prothrombin time (PT) and seven had prolonged activated partial thromboplastin time (APTT), both of which were corrected by the administration [ncbi.nlm.nih.gov]

Blood results revealed unmeasurable INR and abnormally prolonged activated partial thromboplastin time (APTT). [ncbi.nlm.nih.gov]

[…] is elevated, but the partial thromboplastin time is normal or only mildly prolonged. [en.wikipedia.org]

Anticardiolipin Antibody Syndrome

Antiphospholipid antibodies are associated with an increase in arterial and venous thrombosis despite the prolongation of the activated partial thromboplastin time (1,3). [fetalultrasound.com]

Lupus anticoagulant is suggested by a prolonged activated partial thromboplastin time (APTT) and confirmed by prolongation of the diluted Russell viper venom test (DRVVT) [ndt.oxfordjournals.org]

Acquired Factor XIII Deficiency

Posted on January 7, 2016 A physician may order mixing studies when a patient’s prothrombin time (PT), activated partial thromboplastin time, (aPTT) or both PT and aPTT are [kingbiomed.com]

Coagulation studies were normal, with a mildly prolonged activated partial thromboplastin time (aPTT; 44 s, normal value 20–40 s). [anesthesiology.pubs.asahq.org]

prolonged outside the upper limit of the laboratory’s established normal range. [kingbiomed.com]

Portal Cirrhosis

[…] prothrombin time (PT) Prolonged international normalized ratio (INR) Prolonged activated partial thromboplastin time (aPTT) This condition does not respond to Vitamin K because [amboss.com]

[…] cirrhosis characterized by the presence of jaundice, ascites, variceal hemorrhage, or hepatic encephalopathy Clinical manifestations Hematologic manifestations Coagulopathy ;: Prolonged [amboss.com]

Von Willebrand Disease

Laboratory studies revealed isolated prolongation of the activated partial thromboplastin time, which corrected in a mixing study. [ncbi.nlm.nih.gov]

The individuals with VWD have a normal prothrombin time [10]. Activated partial thromboplastin time The activated partial thromboplastin time is normal often. [ijpsonline.com]

[…] of activated partial thromboplastin time (aPTT) or a personal history of bleeding. [jamanetwork.com]

Systemic Lupus Erythematosus

She was also found to have prolonged prothrombin time (PT) and activated partial thromboplastin time (aPTT), positive lupus anticoagulant (LA) and low factor II levels. [ncbi.nlm.nih.gov]

Although LAC is prothrombotic, the clinician must be aware that it can falsely prolong activated partial thromboplastin time (aPTT), and conversely any increased aPTT result [journals.lww.com]

Gaucher Disease

activated partial thromboplastin time, and pyrexia. [medicalnewstoday.com]

Prolongation of both the prothrombin time (PT) and the activated partial thromboplastin time (APTT) in GD patients has prompted the testing of individual coagulation factor [onlinelibrary.wiley.com]

Headache, nasopharyngitis, traumatic injury, arthralgia, cough, pyrexia, dizziness, nasal congestion, influenza, bone pain and prolonged activated partial thromboplastin time [doi.org]

Acute Promyelocytic Leukemia

The pancytopenia also causes abnormal results in other tests, such as a prolonged prothrombin time (PT) and activated partial thromboplastin time (APTT), high levels of fibrin [symptoma.com]

[…] fibrin degradation products or D-dimers combined with prolonged prothrombin time, or activated partial thromboplastin time, as well as increased white blood cell and peripheral [bloodjournal.org]

Patients at high risk of developing fatal hemorrhagic complications have been associated with the following factors: active bleeding, hypofibrinogenemia (< 100 mg/dL), increased [bloodjournal.org]

Factor IX Inhibitor

In laboratory tests, isolated prolongation of activated partial thromboplastin time (aPTT) can be found, but it is necessary to determine the plasma levels of factor VIII [ncbi.nlm.nih.gov]

The activated partial thromboplastin time (aPTT) is prolonged in people with hemophilia B. [drugbank.ca]

A diagnosis should be considered in patients with a recent onset of abnormal bleeding and an isolated prolongation of the activated partial thromboplastin time (aPTT), especially [rarediseases.org]

Heparin

Biological tests showed that their APTT (activated partial thromboplastin time) prolonging activity and intrinsic factor Xase complex (factor IXa-VIIIa-Ca 2+ -PL complex) [ncbi.nlm.nih.gov]

partial thromboplastin time (aPTT) and activated clotting time (ACT). [ncbi.nlm.nih.gov]

APTT Activated partial thromboplastin time (APTT) is a conventional screening test that measures the prolonged clotting time of recalcified citrate-anticoagulated plasma in [diapharma.com]